A corner stone of Physics is the Energy Conservation principle which states that the Energy is always conserved and that the Energy, embedded in the whole Universe, cannot disappear or be created from nothing. This should imply that the Total amount of the Energy, which is embedded in the whole Universe, must be a constant value. However, Humans are not able to devise means or experiments which will provide the exact amount of the Energy embedded in the whole Universe, which implies that Humans are not able to devise means or experiments which will conclude, with complete validity, that the amount of the Energy embedded in the whole Universe, can be indeed represented by a constant value. The above implies that Humans are not able to provide a proof for the Energy Conservation Principle, which means, that the Energy Conservation Principle is presented only as an axiom, and no discussion was yet provided as to the extent of validity that Humans can attribute to the Energy Conservation Principle, even though, it is a corner stone of the nowadays Science of Physics. Thus, in view of the above, this paper tries to examine the extent of the validity that Humans can attribute, to the Energy Conservation Principle. Initially, this paper tries to explore, if the evaluation of the amount of Energy, only in certain specific Energy components, in the Universe, will result in the evaluations of the same Energy amounts, by all Human evaluators, or, if separate Human evaluators might arrive at different results, relating to the Total Energy Content, of these certain several specific Energy components, which they evaluated. Thus, in view of the above, this paper provides significant arguments that two separate Humans, evaluating the Total Energy Content of certain several specific Energy components, in the Universe, might arrive at different results, relating to this Total Energy Content, of these several specific Energy components, which they evaluated.