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Oncology Meets Cardiology: Bevacizumab-Associated Cardiomyopathy in a Patient with He...
Mohammad Hamza Bin Abdul Malik
Muhammad  Arham

Mohammad Hamza Bin Abdul Malik

and 4 more

February 03, 2025
A document by Mohammad Hamza Bin Abdul Malik . Click on the document to view its contents.
Differential roles of duplicate genes OsATG9a and OsATG9b in development and drought...
Yiming Li
Yuantai Liu

Yiming Li

and 13 more

February 03, 2025
Gene duplication events frequently occur during eukaryotic genome evolution, often leading to functional redundancy for organism survival in complex environments. However, whether duplicate genes evolve diverse functions remains unclear. In this study, we explored the roles of autophagy-related gene 9 OsATG9a and OsATG9b in rice development and drought stress responses. Autophagy, an evolutionarily conserved degradation pathway, plays a critical role in multiple biological processes by recycling cellular components. We found both OsATG9a and OsATG9b involved in autophagy, with functional redundancy affecting traits like grain size, plant height, tiller number, primary branch number, and panicle length. Notably, OsATG9b exhibited a distinct response to drought stress. The osatg9a mutant displayed a lower survival rate than wild type (WT) after drought stress, similar to other osatg mutants, while the osatg9b mutant showed the opposite. Moreover, autophagy flux decreased in osatg9a mutant but increased in osatg9b, surpassing WT response. Overexpression of OsATG9b resulted in lower survival rates and reduced autophagy induction under drought stress. Moreover, the response of ABA related genes in osatg9a and in osatg9b were opposite compared with WT. These suggest that OsATG9a promotes autophagy during drought stress, while OsATG9b negatively impacts it, representing a newly evolved function in rice by differently regulating ABA pathway. Our findings provided insights into the functional divergence of duplicate genes during evolution.
Comparing Groundwater Recharge Rates Estimated Using Water Table Fluctuations and Chl...
Stephen Lee
Dylan J. Irvine

Stephen Lee

and 3 more

February 18, 2025
Estimation of groundwater recharge rates (GRRs) in space and time is notoriously challenging but underpins water resource management. GRRs derived from different techniques often differ as they estimate different components (i.e., potential, net, gross) and/or estimate different GRR mechanisms (i.e., diffuse or focused). We evaluate GRRs from daily groundwater level data from ~400 bores across Australia using the water table fluctuation (WTF) method. Specific yield values are estimated using lithological information linked to literature values. Comparisons were made between mean inter-annual GRRs from 224 bores and long-term GRRs derived from the chloride mass balance (CMB) method. Mean inter-annual WTF-based GRRs were 365.5 mm/y for humid, 248 mm/y for dry subhumid, 128.6 mm/y for semi-arid and 50.3 mm/y for arid zones. Inter-annual recharge variability is higher in arid and semi-arid climate zones relative to wetter climates. WTF and CMB-based GRR estimates exhibited low agreement in arid and semi-arid zones, where most WTF-derived GRRs exceeded CMB values by over an order of magnitude. While this can be explained by differing dominance of focused vs diffusive recharge, we show influence from other factors including the inability of the WTF method to quantify low GRRs, impacts of land use change, and non-ideal conditions like river-aquifer connections. Major differences between the WTF and CMB methods are attributed to CMB reflecting pre-land clearing GRRs in many instances. This study serves as a comparative framework for evaluating the appropriateness and differences between the WTF and CMB methods which can be applied to groundwater recharge studies globally.
Unforeseen Complications: Cauda Equina Syndrome After Vaginopla...
Toni Seppälä
Kaisu Ojala

Toni Seppälä

and 1 more

February 03, 2025
Unforeseen Complications: Cauda Equina Syndrome After VaginoplastyToni P Seppälä1, MD, PhD and Kaisu Ojala1, MD, PhD.Department of Plastic and Reconstructive Surgery, HUS, Helsinki University Hospital, Helsinki, Finland.
The Annals of Anticoagulation: A description of maternal and foetal outcomes in pregn...
Jenneker M
Ramnarain H

Jenneker M

and 3 more

February 03, 2025
Objective To retrospectively audit and describe maternal and foetal outcomes in pregnant women with prosthetic mechanical heart valves (MHV) using various formulations of anticoagulation, namely: (1) warfarin only versus (2) warfarin with sequential therapy with unfractionated heparin (UFH) or enoxaparin or (3) dose adjusted enoxaparin only. Design A 6-year single site retrospective audit from 2017 to 2022. Setting The study was conducted at a single site tertiary hospital, Inkosi Albert Luthuli Central Hospital in Durban, South Africa. Population All pregnant women with a history of mechanical valve replacement requiring lifelong anticoagulation. Methods A retrospective audit of all hospital records using keywords (warfarin, enoxaparin, pregnancy, mechanical heart valves) were used to identify and extract eligible participants for inclusion in the study. Main outcome measures The main outcome sought to describe maternal and foetal outcomes with a focus on maternal thrombo embolic complications, bleeding and foetal affectation in particular warfarin toxicity and fetal wastage. Results The study showed that 9% of pregnant women with MHV were at risk of thrombo embolic complications (TEC), with 9.8% in the warfarin group and 7.9% in the enoxaparin group (p= 0.69). There were higher rates of post-partum bleeding complications in the enoxaparin group (p= 0.035). In particular, individuals treated with enoxaparin had a 20% significantly higher likelihood of achieving live births compared to those treated with warfarin, (risk ratio (RR): 1.20; 95% CI: 1.06-1.07, p<0.001 Conclusion Pregnant women on therapeutic anticoagulation for mechanical heart valve prosthesis are at significant risk for adverse maternal morbidity.
Targeting EBNA1 in EBV associated Tumorigenesis
Ranjeet Singh Mahla

Ranjeet Singh Mahla

February 03, 2025
A document by Ranjeet Singh Mahla. Click on the document to view its contents.
A rare and distinct type case report of Fluid overload-associated large B-cell lympho...
Li Chen
Xiaoli Zhai

Li Chen

and 4 more

February 03, 2025
1. IntroductionFluid overload-associated large B-cell lymphoma (FO-LBCL) is a rare subtype of non-Hodgkin lymphoma (NHL), typically associated with body cavity effusions and showing indolent clinical behavior. There is no established standard treatment for this condition. This report discusses a case of FO-LBCL in a patient with cirrhosis, effectively treated with a low-dose regimen of lenalidomide, rituximab, and dexamethasone, highlighting its potential as a therapeutic option for similar cases.
Hemophilia B with intracranial hemorrhage rehabilitation in high dependency unit: a c...
Xiaoyan Feng
Hongjun  Zhu

Xiaoyan Feng

and 4 more

February 03, 2025
Hemophilia B with intracranial hemorrhage rehabilitation in high dependency unit: a case report
“Because I’m black, I’m expected to be strong and endure”: A Qualitative Study of the...
Victoria Yesufu
Rasaq Jimoh

Victoria Yesufu

and 5 more

February 03, 2025
Background: Migrant Black African women encounter substantial barriers when accessing RH services in the United Kingdom. These challenges stem from systemic issues such as cultural insensitivity, racial disparities, and healthcare biases, which negatively impact their care and health outcomes. This study seeks to explore the lived experiences of these women in the context of RH to provide a deeper understanding of the unique challenges they face within the context of systemic inequalities to improve RH access and quality. Methods: This qualitative study employed in-depth online or face-to-face interviews with 12 migrant Black African women in the UK. The research captured their narratives, focusing on their RH experiences. A thematic analysis was conducted to explore key themes from the data, ensuring a diverse range of perspectives and lived experiences were documented. Result: Five prominent themes emerged from the women’s narratives: experiences and perceptions, disparities in maternal healthcare, cross-cultural perspectives, autonomy, and enhancing RHS. Challenges of not feeling understood as an outsider, disregarding voice and pains and variation in antenatal expectation were mentioned among others. However, access to preventive care and promptness during antenatal visits were recognised as part of the strength of NHS services. Continuous funding of NHS services, improvement in the attitude of NHS staff, focus on early pregnancy and strengthening of home visits were advised to keep experiencing safe and effective RHS in the United Kingdom. Conclusion: These findings underscore the need for a more culturally sensitive, patient-centred healthcare system and the insights provide a foundation for addressing systemic inequities in RH for migrant women.
Illegal Disposal of Domestic Solid Waste: A Rights-Based Analysis of Werabe Town, Sil...
Tesfaye Doboch Wanore
Abyot Abebe Alaye

Tesfaye Doboch Wanore

and 1 more

February 03, 2025
This manuscript examines the illegal disposal of domestic solid waste in Werabe Town, Siltie Zone, Ethiopia, through the lens of the right to a clean and healthy environment. It analyzes the current waste management practices, identifies the key challenges contributing to illegal dumping, and explores the implications for public health and human rights. The study utilizes a mixed-methods approach, combining quantitative data on waste generation and disposal with qualitative data gathered through interviews and focus group discussions with residents, local authorities, and waste management personnel. The findings highlight the urgent need for improved waste management infrastructure, strengthened enforcement of existing regulations, and increased public awareness campaigns to protect the right to a clean and healthy environment in Werabe Town. The study concludes with recommendations for policy and practice changes to address the issue effectively and sustainably.
A Rare Case of Lichen Planus Mimicking Secondary Syphilis: The...
Iman Bouchelkia
Jaime Tschen

Iman Bouchelkia

and 1 more

February 03, 2025
TITLE PAGE Title: A Rare Case of Lichen Planus Mimicking Secondary Syphilis: The Great Imitator Unveiled Authors: Iman Bouchelkia, BSa, Jaime Tschen MDb
Unraveling audiovisual perception across space and time: A neuro-inspired computation...
CRISTIANO CUPPINI
Eleonore Di Rosa

CRISTIANO CUPPINI

and 3 more

February 02, 2025
The accurate perception of audio-visual stimuli heavily relies on the spatial and temporal alignment of the sensory cues, with multisensory enhancement only occurring if those cues are presented in spatiotemporal congruency. While spatial localization processing and temporal binding regulation of audiovisual information have been deeply investigated separately, many of the neural correlates subtending audiovisual interactions in spatiotemporally varying conditions remain unclear. Empirically evaluating the respective contribution of spatial and temporal discrepancies on behavioral responses may be challenging when they vary simultaneously. Here, we sought to investigate the mutual interaction of temporal and spatial offsets in cue presentation on the neural processing of audiovisual cues. To this end, we developed a biologically inspired neurocomputational model that reproduces behavioral evidence of perceptual phenomena observed in audiovisual tasks, i.e. the modality switch effect (temporal realm), and the ventriloquist effect (spatial realm). Tested against the race model, our network proved also able to successfully simulate multisensory enhancement due to the concurrent presentation of audiovisual cues in reaction times. Further investigation on the mechanisms implemented in the network upheld the centrality of cross-sensory inhibition in explaining Modality Switch Effects, and of cross-modal and lateral intra-area connections in regulating spatial localization, respectively. Finally, the model predicts an amelioration in temporal detection of different modality stimuli with increasing between-stimuli eccentricity, and indicates a plausible reduction in auditory localization bias for increasing inter-stimulus-interval between spatially disparate cues.
From Resilience to Collapse: Review on Brain topology in Early Onset Dementia
Hema  Nawani
Ranjith  Jaganathan

Hema Nawani

and 3 more

February 02, 2025
not-yet-known not-yet-known not-yet-known unknown Early-Onset Dementia (EOD), which includes Frontotemporal Dementia (FTD), behavioral variant (bvFTD) and Early-Onset Alzheimer’s Disease (EOAD), poses significant diagnostic and therapeutic challenges due to its diverse clinical manifestations and unique neurodegenerative mechanisms. This review integrates findings from studies employing advanced neuroimaging modalities—electroencephalography (EEG), functional MRI (fMRI), Diffusion Tensor Imaging (DTI), and fluorodeoxyglucose positron emission tomography (FDG-PET) analyzed through graph-theoretical frameworks to investigate topological disruptions associated with EOD. Metrics such as global efficiency, local efficiency, hubs, and modularity provide critical insights into the altered topological organization of brain networks in EOD. Graph network analysis reveals paradoxical preservation of small-world properties and compensatory mechanisms in the early stages of EOD, juxtaposed against a progressive decline in network efficiency and modular integration as the disease advances. Traditional metrics like global efficiency and small worldness may oversimplify dynamic compensatory processes and disease-specific network changes. Hallmarks of EOD include hub vulnerability, rich club network disruptions, and modular breakdowns, which reflect the selective impact of tau and amyloid pathologies on brain connectivity. These findings highlight the clinical value of graph-theoretical approaches in differentiating EOD subtypes, tracking disease progression, and guiding therapeutic strategies. Future research should prioritize the standardization of methodologies, longitudinal studies to monitor dynamic network alterations, and a deeper exploration of compensatory mechanisms to enhance early diagnosis and develop targeted interventions for EOD. This approach holds promise for advancing both the understanding and management of this complex condition.
A Constitutional Right to Cannabis? Grassroots Litigation and Dagga Policy Reform in...
Kenzi Riboulet-Zemouli

Kenzi Riboulet-Zemouli

and 1 more

February 10, 2025
South Africa’s interaction with Cannabis sativa L.—locally known as dagga or ntsangu—spans centuries and reflects the nation’s complex history. Early prohibition, influenced by colonial dynamics, set the stage for the apartheid regime’s stringent criminalisation of dagga users and growers during the ensuing decades, further enshrined in a 1992 law (two years before the fall of the regime). Following 30 years of strategic litigation, a turning point was reached in 2018 when the Constitutional Court declared that the prohibition of the private use and cultivation of dagga was unconstitutional. This decision paved the way for the 2024 Cannabis for Private Purposes Act, which was enacted exactly 100 years after the first nationwide ban on cannabis in South Africa. This article examines the legal and historical trajectory leading to these developments, the pivotal role of grassroots litigation, and the ongoing legislative challenges that continue to shape South Africa’s dagga policy. By reflecting on the unique characteristics of the South African approach, this article contributes to the broader discourse on cannabis legalisation and the interplay between human rights and drug policy.
Calculation of Stress Intensity Factor in Human Teeth using Fracture Mechanics: A Fin...
A. Al-Mukhtar
Carsten Koenke

A. Al-Mukhtar

and 1 more

February 02, 2025
Cracks are an early indicator of fractures and can be initiated during various dental treatments and during the cyclic loading stresses, commonly referred to as fatigue. This study aims to explore the mechanical factors contributing to tooth fractures that helps reduce the risk of failure. Cracks typically propagate through enamel that has lower fracture toughness. As the crack progresses toward the dentin-enamel junction (DEJ), the material becomes more ductile and exhibits higher fracture toughness. Whether the crack is arrested or continues to propagate depends on factors such as tooth health, and age. The study concluded that isotropic models provide an adequate representation for simulating cracks in enamel. Therefore, Linear Elastic Fracture Mechanics (LEFM) was employed to assess the fracture toughness. The stress intensity factor (SIF) was calculated for different crack lengths, indicating that longer cracks result in higher stress intensities, thus reducing the number of cycles required for failure.
An existence result for a general non-linear parabolic equation and related eigenvalu...
Fabio Botelho

Fabio Botelho

February 03, 2025
This article develops an existence result for a general non-linear parabolic equation and related eigenvalue problem. The method of proof comprises a variational approach for establishing a concerning solution existence at each instant of time, related to a model discretized in time. The main difference concerning the previous version, is that we have made some improvements and corrections concerning a heuristic part of the previous proof, presenting now a formal rigourous result. In particular, as a novelty in this last version, we prove in details the minimizing sequences are uniformly bounded in an appropriate norm, independently of a natural parameter N which corresponds to the number of nodes for such a model discretized in time.
An existence result for a general non-linear parabolic equation through a variational...
Fabio Botelho

Fabio Botelho

February 03, 2025
This short communication develops an existence result for a general non-linear parabolic equation. The method of proof comprises a variational approach for establishing a concerning solution existence at each instant of time, related to a model discretized in time. The main difference, concerning a previous version, refers to a rigourous development for proving the related minimizing sequences are uniformly bounded in norm, independently of a specific natural parameter N, which corresponds to the number of nodes for such a model discretized in time.
A simple surveyor's error condemned the White Terrace, Wonder of the World
Alfred Rex Bunn

Alfred Rex Bunn

February 05, 2025
The loss of the Pink and White Terraces, the New Zealand Eighth Wonder of the World, was declared by a government surveyor S. Percy Smith on 14 June 1886, four days after the Tarawera eruption when he approached ~4,000 m from his supposed site of Te Tarata, the White Terrace(s). This research follows his loss claim through three parliamentary reports, an audit, five government survey maps and four artworks prepared by Smith from 1886-1894. His evidence is for the first time examined with the aid of a unique survey by Ferdinand Hochstetter, first published during 2016-2023. Alterations across Smith's survey map series, indicate he changed his location for the White Terrace without mention and invented features to support his case, while he was being audited and with government ministers sceptical of his claim. The Māori in Rotorua disclaimed Smith's report but given interracial conditions at this period, colonial bias meant their advice was not in official reports. Reports of Smith's adventitious pre-eruption bearings on the White Terraces are reproduced. The research extends the first evidence-based altimetry for the Rotomahana Basin. Hochstetter's survey location of the White Terrace is strengthened by error ellipses. LIDAR imagery is included for the White Terrace location to assist passive seismic surveying. It also shows the course of the true Kaiwaka Channel, confirming Smith also misidentified the outlet of Lake Rotomahana. It is concluded Smith had no substantive evidence for his claims and engaged in research misconduct. Hochstetter's and recent surveying rebuts his reports.
Tratamientos de Agua para Consumo Humano Garantizando la Calidad del Agua Potable
Xavier Pardell Peña

Xavier Pardell Peña

and 1 more

February 03, 2025
A document by Xavier Pardell Peña. Click on the document to view its contents.
If You Can’t Take the Heat: Evaluating Thermoregulatory Behaviors Used by Birds
Emmy James
Elizabeth  Derryberry

Emmy James

and 1 more

February 01, 2025
As global temperatures rise, many animals encounter longer and more intense heat. Behavioral thermoregulation offers a potential means of staying cool, but there is no clear consensus on how to evaluate when thermoregulatory behaviors are actually working. Here, we examine the efficacy of thermoregulatory behaviors in birds. We begin by broadening the definition of avian thermoregulatory behaviors to include actions related to self-maintenance, parental care, and social interactions. We then examine the limitations of these behaviors, focusing on ecological tradeoffs and synergies that constrain their efficacy. Finally, we review the methodologies used to test these behavioral strategies, considering their effectiveness at both proximate and ultimate levels. By examining the role of thermoregulatory behaviors across ecological contexts, we aim to illuminate their potential and limitations as shields in a warming world and highlight avenues for future research.
Evaluating the Functional Realism of Deep Learning Rainfall-Runoff Models Using Catch...
Majid Bayati

Ara Bayati

and 2 more

February 03, 2025
We propose a hydrologic-specific Explainable AI (XAI) framework to extract nonlinear and nonstationary Impulse Response Functions (IRFs) used by Long Short-Term Memory (LSTM) models to simulate streamflow. IRFs reveal how LSTMs emulate streamflow generation and celerity propagation processes in response to impulses of precipitation (P), temperature (T), and potential-evapotranspiration (PET), enabling the evaluation of LSTMs' functional realism under short-term and long-term varying climate/weather conditions. Applying this framework to 672 catchments in USA and Canada, we found that while LSTMs achieve exceptionally high predictive accuracy, their extracted functionality often contradicts established hydrologic principles. Unexpectedly, the isolated effects of T or PET short-term variations on LSTM's simulated streamflow and celerity rate are often positive in direction. For example, in over 70% of raindominated catchments, particularly along the Pacific Coast, increased T within 1-14 days prior to streamflow events is associated with higher streamflow and celerity rates. Similarly, in the southeastern USA and California, LSTMs predict increased streamflow solely in response to PET rises. In snow-dominated catchments, particularly in the Rockies, LSTMs misinterpret PET (representing evaporation function) as a proxy for temperature, the primary snowmelt's driver. These behaviors, likely influenced by seasonality in dynamic inputs, data non-homogeneity, simplicity bias, and missing causal factors, undermine LSTMs' scientific reliability for streamflow forecasting and climate impact assessments. Our XAI framework integrates deep learning with hydrologic context through Differentiable modeling, providing a screening tool for the evaluation of hydrologic models' functional realism in short-and long-term forecasting, climate change studies, and generalization to ungauged basins.
Autonomous operation and quality monitoring of a continuous antibody downstream proce...
Madelène Isaksson
Daniel Espinoza

Madelène Isaksson

and 5 more

February 01, 2025
The transition from batch-wise to integrated continuous manufacturing of biopharmaceuticals has gained significant attention over the past decade. While this concept has been thoroughly studied, there remains significant room for improvement in terms of process automation and real-time monitoring. This study showcases the implementation of an integrated downstream process at a lab scale, operating continuously and autonomously. The purification process included solvent/detergent-mediated virus inactivation in a packed bed reactor, Protein A capture via a three-column periodic counter-current chromatography process with UV-based loading, and a mixed-mode chromatography polishing step in flow-through mode. Support systems for at-line automated sample collection and high-performance-liquid chromatography analysis for near-real-time quality monitoring, along with autonomous buffer management, were introduced. The process operated for over five days, with two disturbances introduced: decreased capture column capacity and increased harvest titer. The high level of automation and control allowed the process to adapt to these disturbances. Throughout the run, the product was sampled, and quality analyses were performed, achieving an average monomer content of 94% and an overall yield above 90%. This study demonstrates the feasibility of introducing autonomous integrated continuous downstream processes at a lab scale, enabling users to concentrate on process and control development.
Bitter Taste Receptors in Inflammatory and Infectious Diseases
Erin Rudolph
Hannah Dychtenberg

Erin Rudolph

and 3 more

February 01, 2025
Bitter taste receptors (TAS2Rs), initially identified for their role in detecting bitter compounds in the oral cavity, have emerged as multifunctional receptors with critical roles beyond taste perception. These G protein-coupled receptors are expressed in various extra-oral tissues, where they influence immune responses, inflammation, and cellular processes associated with both infectious and chronic diseases. TAS2Rs play a key role in pathogen detection, immune modulation, and physiological regulation, contributing to defense mechanisms and homeostasis across multiple systems, including the respiratory, cardiovascular, metabolic, and central nervous systems. Their unique signaling pathways, broad ligand specificity, and genetic polymorphisms highlight their complex roles in health and disease. As our understanding of TAS2Rs deepens, these receptors are gaining recognition as potential therapeutic targets for managing a wide range of conditions. However, significant challenges remain, including interspecies variability and the limited in vivo characterization of their functions. Advances in technologies such as cryo-electron microscopy and transgenic models are providing valuable insights into TAS2R structure and function, paving the way for the development of novel therapeutic strategies. This review explores the expanding landscape of TAS2R research, emphasizing their emerging importance in addressing pressing global health challenges.
Evaluating LEAF GUI versus ImageJ for leaf vein density measurement
Xuchen Guo
Qingyue Miao

Xuchen Guo

and 3 more

February 01, 2025
Leaf vein density (LVD) is a critical trait linked to leaf hydraulic efficiency, commonly quantified using an automated tool—LEAF GUI, which analyzes vein structures via pixel-based algorithms. However, concerns persist about its accuracy for species with complex hierarchical venation networks. To evaluate the reliability of LEAF GUI, we compared its LVD measurements against those from ImageJ—a manual tracing platform renowned for its precision—using leaf specimens from nine Magnoliaceae species. Paired t-tests revealed no statistically significant differences between the two methods (P = 0.534), demonstrating comparable accuracy under standardized conditions. However, LEAF GUI’s reliability is constrained by its reliance on laborious threshold calibration and stringent image quality standards. For studies prioritizing precision, especially in taxa with heterogeneous or low-resolution samples, we recommend ImageJ as the standard approach. Its manual tracing protocol achieves consistency in resolving complex vein networks, balancing analytical rigor with adaptability to diverse sample conditions
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