Cancer patients, particularly those post-surgery, are prone to skin infection following immersion in flood waters. We reported secondary surgical site infection in a postoperative 80-year-old post-operation breast cancer patient affected by Typhoon Hagibis. Individualized responses based on individual and environmental risks are crucial to alleviate the damage of disasters.

We reported a case of M. szulgai respiratory infection in a 32-year-old male patient without any history of smoking, immunodeficiency syndromes, or receiving immunosuppressive medications but the patient was severely deficient in vitamin D. isoniazid, rifampin, ethambutol, clarithromycin antimicrobial agents with vitamin B6 and vitamin D.improved after 10 months.

L1 syndrome is an X-linked disorder manifesting with congenital hydrocephalus, adducted thumbs and spasticity. There are rare cases of L1 syndrome and coincident Hirschsprung disease, with mutations in the L1CAM gene thought to underlie both. We present a novel pathogenic L1CAM variant in someone with L1 syndrome and Hirschsprung disease.

Multifocal lesions with necrotic center and peripheral enhancement can be a diagnostic challenge. Magnetic resonance imaging with advanced sequences, such as perfusion, can be confusing, as some inflammatory lesions can show hyperperfusion, mimicking tumors. We present a case of neurotuberculosis with multifocal lesions which diagnosis was confirmed by brain biopsy.

In this paper, we present new results on deterministic sudden changes and stochastic fluctuations effects on the dynamics of a two-predator one-prey model. We purpose to study the dynamics of the model with some impacting factors as problem statement. The methodology depends on investigating the seasonality and stochastic terms that which makes the predator- prey interactions more realistic. A theoretical analysis is introduced for studying the effects of sudden deterministic changes, using three different cases of sudden changes. We show that the system in a good situation presents persistence dynamics only as a stable dynamical behavior. However, the system in a bad situation leads to three main outcomes, as follows: first, constancy at the initial conditions of the prey and predators; second, extinction of the whole system; and third, extinction of both predators, resulting in the growth of the prey population until it reaches a peak carrying capacity. We perform numerical simulations to study effects of stochastic fluctuations, which show that, noise strength leads to an increase in the oscillations in the dynamical behavior and became more complex, finally, leads to extinction when the strength of the noise is high. The random noises transfer the dynamical behavior from the equilibrium case to the oscillation case, which describes some unstable environments

The closed crack and micro damage are liable to be underestimated in conventional (linear) ultrasonic nondestructive testing, which lead to unpredictable safety hazards. The objective of this work was to detect the fatigue damage in the stainless steel samples by use of nonlinear ultrasonic method. In the first, the macro cracks of fatigue specimens were measured by metallographic method. Secondly, the finite amplitude method of nonlinear ultrasonic testing was employed to evaluate the micro damages, and both the linear and the nonlinear characteristics of testing signals were investigated. Thirdly, the influences of excitation voltage on the finite amplitude method were discussed. The results indicate that the maximum value of the relative nonlinearity parameter is sensitive to the closed cracks and micro damages which are unable to be detected by the amplitude of linear ultrasonic testing. Higher excitation voltage is beneficial for exciting the nonlinear response of closed crack, which can be used to evaluate the degree of fatigue damage.

HEALTH INSURANCE PROVIDED BY GOVERNMENT VS PRIVATE SECTOR IN INDIA

Herniation of intra-abdominal viscera through pelvic bone defects represents an extremely uncommon complication following orthopaedic interventions in the bony pelvis. We report a rare case of acute colonic obstruction through a defect in the iliac bone, following bone graft harvesting from the iliac crest, aiming to raise clinical awareness.

Tunnel passing in high speed produces aerodynamic load on railway train, which brings about fatigue failure on the car-body, and damages passenger comfort due to interior penetration of the alternating wave. Experimental simulation of the alternating load remains a challenge concerning its accuracy and reliability. In this work, experiment approaches in terms of air compression and air suction were developed, in an attempt to simulate the air pressure variation when the train runs through tunnels. Pros and cons of the introduced methods were analyzed by theoretical calculation and numerical simulation, and further validated in experimental tests. It is revealed that in air compression means of eccentric wheel and stepping motor propulsion, pressure amplitude in simulation both exceeds that in theoretical calculation due to temperature change from piston movement. The deviation between tests and theoretical values climbs up as the pressure wave cycle rises. The stepping motor propulsion is recommended in scaled simulation for human ear comfort because of its equal peak and valley span, but suggests insufficient engineering feasibility in full size vehicle tests. However, the air suction performs excellently through internal and external loading utilizing the valve controlling strategies. By simulating the pressure wave obtained from in-transit vehicle tests, the relative deviation of the extremes between simulation and vehicle tests is within 5.0%. Research outcome indicates that the proposed method provides an important experiment means for passenger comfort and car-body fatigue behavior research.

Background: Exercise intolerance is a common side-effect of treatment for childhood leukemia and lymphoma and contributes to adverse health and well-being during survivorship. While central, cardiovascular contributors to fitness have been shown to be impaired, the peripheral muscular factors have not been studied in this population. Therefore, peripheral muscular function in children after leukemia and lymphoma treatment remains unstudied. Procedure: Eleven leukemia and lymphoma patients aged 8-18 years old who completed treatment 6-36 months prior and 11 healthy controls were included in analysis. 31P-MRS was used to characterize muscle bioenergetic metabolism at rest and after in-magnet knee extension exercise. General exercise capacity was assessed using a submaximal graded treadmill test and overall physical activity participation was assessed using the Habitual Activity Estimation Scale (HAES). Results: The patients treated for leukemia and lymphoma exhibited lower anaerobic function (d=0.72), slower metabolic recovery (d=0.93), and lower mechanical muscle power (d=1.09) during in-magnet knee extension exercise compared with the healthy control group. Lower estimated VO2peak (41.61 ± 5.97 vs. 47.71 ± 9.99 ml.min-1.kg-1, d=0.76), lower self-reported minutes of physical activity (58.3 ± 35.3 vs. 114.8 ± 79.3 minutes, d=0.99) and higher minutes of inactivity (107.3 ± 74.0 vs. 43.5 ± 48.3 minutes, d=1.04, p<0.05) were also observed in the patient group. Conclusions: Children treated for leukemia and lymphoma exhibit altered peripheral skeletal muscle energy metabolism in addition to previously reported central cardiovascular limitations during exercise. It is likely that both deconditioning and direct effects of chemotherapy treatment contribute to exercise intolerance in this population.

PUBLISHED IN REVIEWS IN FISH  BIOLOGY AND FISHERIES: https://doi.org/10.1007/s11160-021-09674-8Kathryn A. Willis1,2,5†, Catarina S. Gonçalves1,3, Kelsey Richardson1,2,5, Qamar A. Schuyler2, Halfdan Pedersen8, Kelli Anderson4, Jonathan Stark7, Joanna Vince1,5, Britta D. Hardesty2, Chris Wilcox2, Barbara Nowak4, Jennifer L. Lavers3, Jayson M. Semmens3, Dean Greeno1,6, Catriona MacLeod3, Per Ole Frederiksen (Nunnoq)9,10, Peter S. Puskic1,3*†1 Centre for Marine Sociology, University of Tasmania, Hobart, Tasmania, Australia2 CSIRO Ocean & Atmosphere, Hobart, Tasmania, Australia3 Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, Tasmania, Australia4 Institute for Marine and Antarctic Studies, Fisheries and Aquaculture, University of Tasmania, Newnham, Tasmania, Australia5 School of Social Sciences, College of Arts, Law and Education, University of Tasmania, Hobart, Tasmania, Australia6 School of Creative Arts and Media, College of Arts, Law and Education, University of Tasmania, Hobart, Tasmania, Australia7 Australian Antarctic Division, Hobart, Tasmania, Australia8 Pikkoritta Consultancy, Greenland9 The PSUNA Project, Qaasuitsup Municipality, Attu, Greenland10 Snowchange Cooperative, Selkie, Finland*Corresponding Author: Peter S. Puskic (peter.puskic@utas.edu.au), Centre for Marine Sociology & Institute for Marine and Antarctic Studies; University of Tasmania, Hobart, Tasmania, Australia.† P.S. Puskic and K.A. Willis share equal lead authorship on this paper.

A patient presented with cauda equina syndrome signs on a background of intrathecal pump implantation for chronic pain. Initial investigations were consistent with a granuloma, a common complication of intrathecal pumps. CSF cytometery revealed a lymphocytosis. This patient represented 2 months later with neck signs secondary to a B-cell-lymphoma.

Endophytic fungi have played a very important role in influencing the quality and quantity of bioactive compounds of medicinal plants through specific fungus-host interactions. In medicinal licorices root, a total of 2,118,633 effective sequences and 1,063 effective operational taxonomic units (OTUs) with 97% identity were obtained by high-throughput sequencing. A total of 8 phyla and 140 genera were annotated, among them, the phylum Ascomycota and Basidiomycota, and the genera Fusarium, Paraphoma and Helminthosporium were significantly dominant. Moreover, Wilcoxon rank sum test showed that the Shannon index was significantly different distribution between Glycyrrhiza uralensis and Glycyrrhiza inflata, especially 0-20cm at the root depth, the Chao1 index in Glycyrrhiza inflata was significantly affected by root depth, and there were significant differences in beta diversity between Glycyrrhiza uralensis and Glycyrrhiza inflata. Moreover, we explored the content of bioactive compounds (glycyrrhizic acid, liquiritin and total flavonoids) in roots of medicinal licorices based on high-performance liquid chromatography. Our results showed that the liquiritin content was not affected by the root depth (0-20cm, 20-40cm and 40-60cm), but was significantly affected by the main effect species (Glycyrrhiza uralensis, Glycyrrhiza inflata, Glycyrrhiza glabra) (P < 0.05), and the content of liquiritin was accountable for the differences in the diversity of endophytic fungal community. Furthermore, distance-based redundancy analysis (db-RDA) showed that soil physicochemical properties (available potassium and ammonium nitrogen), and the root factor (liquiritin and water content) were the main contributing factors to the variations in the overall structure of endophytic fungal community in this study.

Pesticide resistance in insects is an example of adaptive evolution occurring in pest species and is driven by the artificial introduction of pesticide. The diamondback moth (DBM), Plutella xylostella L. (Lepidoptera: Plutellidae), has evolved resistance to various insecticides. Understanding the genetic changes underpinning the resistance to pesticides is necessary to the implementation of pest control measures. For this reason, we sequenced the genome of 6 resistant and 6 susceptible DBMs, and inferred the genomic regions of greatest divergence between strains using two indices, Fst and θπ. Among several genomic regions potentially related to insecticide-resistance, a P450 gene, CYP6B6-like, was observed with significant divergence between the resistant and susceptible strains, with, among other SNPs, a missense mutation located near the substrate recognition site (SRS). To characterize the relative effects of directional selection via insecticide tolerance (‘strain’) as compared to acute exposure of insecticide (‘treatment’), four pairwise comparisons were carried out between libraries to determine the differentially expressed genes (DEGs). Most resistant-related DEGs were identified from comparison between strains, and enriched in pathways for exogenous detoxification including cytochrome P450 and ABC transporter. Further confirmation came from the weighted gene co-expression network analysis (WGCNA), which indicated that genes in the significant module associated with chlorantraniliprole-resistance were enriched in pathways for exogenous detoxification, and that CYP6BG1 represented a hub gene in this module. Our study thus provides a genetic foundation underlying selection for pesticide resistance and plausible mechanisms to explain fast evolved adaptation through genomic divergence and altered gene expression in insects.

Objective: To carry out an epidemiological analysis characterizing the type and location of the injury, severity based on recovery time, game position, and injury for hours of exposure. Methods: Data collection was carried out in the sub 15, sub 17, and sub 20 categories and verified records made by the medical team of the club, which was trained to use the F-MARC form (a form of the medical research center of the International Football Federation-FIFA) at the beginning of the season. To perform the data analysis, the GraphPad Prism software was used. All variables were analyzed using the Kolmogorov-Smirnov test. Results: In relation to the 129 athletes monitored during the season, 62 athletes presented some injury during the season, presenting 42.2 injuries for every 1000 hours of play, the Sub 15 category was the one with the highest incidence of injury, followed by the Sub17 and U20. The average time of leave after injury was 3.65 ± 4.2 weeks, the Defenders were the ones with the highest injury rate. There were 27 articular injuries (43.54%), 25 muscle injuries (40.32%), 9 bone injuries (15.41%), and one pathological injury (1.61%), and the most affected regions were ankle and knee. Conclusion: It is concluded that the moment of the game is the moment when the greatest number of injuries occurs, having a greater incidence in the athletes of the category Sub 15, the Defenders suffered more injuries and the Lower Limbs were more affected, mainly by articular traumas.

This paper studies a new kind of generalized Caputo fractional differential quasi-variational inequalities in Hilbert spaces. We prove uniqueness and stability of the abstract inequality by using generalized singular Gronwall's lemma, projection operators and contraction principle. Finally, an example is given to illustrate the abstract results.

Mathematical modeling of uncertain FIDEs is an extremely significant topic in electric circuits, signal processing, electromagnetics, and anomalous diffusion systems. Based on the RKA, a touching numerical approach is considering in this study to solve groups of FFIDEs with ABC fractional distributed order derivatives. The solution-based approach ‎lies in generating infinite orthogonal basis from kernel functions, where uncertain condition is fulfilled. Thereafter, an orthonormal basis is erected to figurate fuzzy ABC solutions with series shape in idioms of η-cut extrapolation in Hilbert space A(D) and B(D). In this orientation, fuzzy ABC fractional integral, fuzzy ABC fractional derivative, and fuzzy ABC FIDE are utilized and comprised. The competency and accuracy of the suggested approach are indicating by employing several experiments. From theoretical viewpoints, the acquired results signalize that the utilize approach has several merits in feasibility and opportunity for treating with many fractional ABC distributed order models. In the end, highlights and future suggested research work are eluded.

Background: Infection caused by SARS-CoV-2 virus is a recent disease that is easily spread and has serious complications, such as neuropsychiatric signs and symptoms. Thus, studies are necessary on the clinical manifestations during and/or after the course of the disease. Aims and objectives: To describe the relationship between neuropsychiatric signs and symptoms and SARS-CoV-2 infection. Methods: Systematic review conducted in the Pubmed Portal, Brazilian Virtual Health Library, Cochrane, and Science Direct databases. The descriptors coronavirus, SARS, and neurologic symptoms were used in Pubmed, Cochrane, and Science Direct databases, while the descriptors SARS Virus and Nervous System were used in the Virtual Health Library database. A total of 1024 studies were found and 67 were selected to compose this systematic review. The studies were analyzed qualitatively with the narrative description divided into four thematic categories. Results: There is a pathophysiological relationship between SARS-CoV-2 infection and manifestations involving the Central Nervous System and the Peripheral Nervous System through different pathways and mechanisms. The chances of Nervous System manifestations increase in elderly patients with associated morbidities, such as obesity, diabetes mellitus, chronic obstructive pulmonary disease and/or pre-existing neurological/psychiatric diseases. The most cited neuropsychiatric signs and symptoms were headache, delirium, smell and/or taste disorders, and stroke. The evaluation and monitoring of patients during and after COVID-19 infection is important for the early detection and treatment of neuropsychiatric signs and symptoms. Conclusions: It is recommended that health professionals monitor patients with COVID-19 infection or who had recently had the disease for detecting neuropsychiatric signs and symptoms, especially elderly patients, people with comorbidities such as cardiovascular and pulmonary diseases, diabetes mellitus, and obesity, and patients with pre-existing neurological/psychiatric diseases. Decision-making for the implementation of an early rehabilitation treatment can be reinforced in this groups, minimizing the sequels resulting from COVID-19.

In late 2019, an outbreak of respiratory disease named COVID-19 started in China and rapidly spread to other parts of the world. To date, millions of cases of infection are reported worldwide. Most researches performed on epidemiology and clinical features of COVID-19 and a small part of studies have focused on the genetic characteristics of this virus. Here we performed six months study on D614G mutation in SARS-CoV-2 isolates. Regarding the high price and low availability of sequencing techniques in Iran, we designed the PCR-RFLP method for D614G mutation detection and then evaluated 1440 SARS-CoV-2 positive samples isolated in six months in Northeastern Iran. The first S-G type was detected on 2020 June 10; after that, the number of S-G types increased in our samples, as in the last three weeks, from 2020 September 07 to 2020 September 26, all samples belonged to this type.

The first-principles methods based on the density functional theory were employed to study the structural stability, segregation and work function of Mg doped with fourteen metal elements existing in human body. The calculated results show that there is a simple correlation between solid solution and segregation. Doping Sn, Y, Li, Gd, Nd, Sc and Zn atoms have a negative formation energy as well as a positive segregation energy. This suggests that these elements which are not easier to be dissolved in Mg matrix tend to segregate on the Mg (0001) surface. An opposite trend was observed for Ba, Fe, Mn, W, Sr, Ca and Mo. On the other hand, the electronic work function of Mg (0001) surface was increased significantly for doping Mo, W, Fe, and Mn, and was reduced markedly for Ba, Ca and Sr. For Li, Sn, Sc, Gd, and Y, their doping on Mg surface generate a relatively small change in work function. In addition, the relationships of corrosion behavior to segregation and work function were discussed. This study may provide an avenue for seeking a more appropriate alloying element of Mg alloys with improved corrosion resistance in biomedical applications.

Continuous Integration (CI) is an approach to be continually validating the state of a codebase through automated testing. Best achieved through integration with version control. Continues Delivery/Deployment (CD) is a method to regularly deploy artifacts that successfully permit the CI phase to ensure assurance around deployment. Continues integration, continuous Deliver/Deployment are like the vectors that have the same direction, but different magnitude. Objectives of CI CD for any software development environment is to make code development and code release Faster in robust fashion. CI CD can automatically prepare and track a release to production, eliminate manual tasks and developers become more productive and eventually quality will not be compromised as standards and governance can be practices on central infrastructure.

Pseudorabies virus (PRV) causes Aujeszky’s disease or pseudorabies (PR), which is characterized by fatal encephalitis in newborn piglets, respiratory infection in growing and fattening pigs, and reproductive failures in pregnant sows. It establishes a lifelong latent infection in the peripheral nervous system followed by subsequent intermittent shedding of infectious virus. Since 2011, highly virulent PRV strains that are genetically different from the classic PRV strains surfaced in pig herds in China. Availability of a highly sensitive and specific polymerase chain reaction (PCR)-based diagnostic assay for rapid differential detection of PRV variants is critical to prevent huge economic losses to the U.S. and Canadian pork industries if these strains enter North America and cause an outbreak. Here we describe the development and evaluation of a single-tube triplex real-time-PCR assay for differential detection of variant strains of PRV. The assay targets the intergenic region between the US2 and US6 genes in the PRV genome, is highly sensitive and specific, and it did not detect other non-target viruses, including related herpesviruses. The clinical specificity and sensitivity of the assay was evaluated using whole blood, serum, tissue and swab samples collected from known negative and experimentally inoculated pigs with either classical (Bristol) or variant (JS-2012 and HeN1) PRV strains. The targeted genomic region of this assay is also deleted in commonly used PRV gE-deleted marker vaccines, and therefore, the triplex assay did not detect viral DNA extracted from two commercial vaccine strains Bartha K-61 and Bucharest. This single-tube triplex assay can be used for routine diagnostics and epidemiological studies for detection and differentiation of classical strains from variant strains of PRV, and as a differentiation of infected and vaccinated animals (DIVA) assay when PRV gE- deletion mutant marker vaccines are used.

In this paper, we consider a particle moves on a space curve in the Euclidean 3-space and resolve its acceleration and jerk vectors according to quasi-frame. In this resolution, by appyling Siacci's theorem, we state the acceleration vector as the sum of its tangential and radial components, and obtain the jerk vector along the tangential direction and radial directions in osculating and rectifying planes. On the basis of the jerk vector formula , we give the maximum admissible speed on a space curve at all trajectory points. Furthermore, we present illustrative examples to explain how our results work.

This research focuses on the development of a new non-destructive inspection method, based on the interpretation of electromagnetic waves by means of a ground penetrating radar (GPR), in order to evaluate the condition of the backfilling two-component mortar grouting behind the segmental lining in tunnels made by tunnel boring machines (TBM). The data processing by digital models and the analysis of the propagation speed of the along the backfilling grouting layer have enabled the technical and operational feasibility of this novel inspection method. Once the conceptual framework of the research was defined, it was possible to validate the developed method in a full-scale operational environment in the Metro of Quito Line 1 (Ecuador). This validation involved a battery of tests collating the results obtained through the core-drilling extractions in comparison with the ones obtained with GPR. As a result of these calibration tests, it was possible to identify a range of propagation speeds linked to grouting in optimal execution conditions, as well as other ranges associated with potential anomalies. Finally, it was possible to implement this new inspection methodology on a regular basis in the Metro of Quito, where the conventional quality control by core-drillings was replaced almost entirely for the new method with GPR.