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Hydraulic and tissue adjustments enable the maintenance of mangrove seedling growth u...
Vanessa Negrão-Rodrigues

Vanessa Negrão-Rodrigues

October 20, 2023
A document by Vanessa Negrão-Rodrigues. Click on the document to view its contents.
Quantification of Chemotherapy Drug Wastage and incurred financial loss in Paediatric...
Shweta Ghate
Swati  Patil

Shweta Ghate

and 4 more

October 20, 2023
Aim:The evolving chemotherapy landscape continually introduces effective agents, but escalating costs call for an evaluation of drug wastage and financial consequences to enhance resource utilization. This study seeks to estimate chemotherapy drug wastage and its economic loss in paediatric cancer care. Methods: In this cross-sectional study of paediatric cancer patients receiving parenteral chemotherapy, we evaluated both the drug used and wasted during each administration. The monetary value of drug loss was calculated using the formula: Cost = Proportion of drug wasted X Cost of drug vial. Result: 100 paediatric cancer patients who received 140 parenteral drug administrations of 22 chemotherapy drugs were studied. Wastage amounted to 19.61% of the procured drugs in varying proportions. The total estimated cost of chemotherapy stood at 110,143.1 INR (1,328.7 USD), with cost wastage accounting for 31,929.95 INR (385.19 USD), equivalent to 28.98% of the total expenditure. Notably, doxorubicin (37.4%) exhibited the highest drug wastage, followed by cytarabine (35%) and l-asparaginase (26.9%), primarily prescribed for acute lymphocytic leukaemia. Cytarabine resulted in the highest financial loss. Dose rounding occurred in 22 cases (15.71%), while vial sharing was observed in only 5 cases (3.57%) during drug administrations. Methotrexate, doxorubicin, and cytarabine doses never matched available vial sizes. Conclusions: In resource-limited healthcare settings, implementing centre-specific measures like vial sharing and drug categorization can reduce drug wastage and financial losses. Evaluating the viability of optimizing vial sizes and producing multidose vials is essential.
Process-based Quantification of the Role of Wildfire in Shaping Flood Frequency
Guo Yu

Guo Yu

and 10 more

December 27, 2023
This work is published in Water Resources Research.     https://doi.org/10.1029/2023WR035013
 A Planck-Einstein-Dirac Model of Electron             
ZhaoXin Wang

ZhaoXin Wang

August 21, 2025
The spherical model of electron should be incorrect as it cannot explain Bohr magneton, de Broglie wave, etc. To explain these properties physically, here we introduce an alternative based on Planck, Einstein, and Dirac’s insights, and classical conservation laws, that an electron is an electrical wave (magnetism is just electricity, Einstein) with a literal ${2}$ spin, i.e., spins two circles in one cycle, its wavelength is determined by $E=h={}=m_0c^2$ (Plank and Einstein), λm₀ is the Compton wavelength. As $ \perp $ for a transverse wave, it has a net electricity due to the first spin, $E_q={2}E_0\left(1-\cos(2\omega_0t)\right)$ that related with charge, Fig.1. Moreover, an electron has a ring shape due to the second spin, 2πR₀ = λm₀, i.e., the electron-impact cross section. As $\hbar={}}{2\pi}=m_0cR_0$, it has a quantized classical angular momentum, with a speed of c. Therefore,its _g_-factor is 2; the Bohr magneton, $={2m_0}\hbar}$. Furthermore, assuming heavy charged particles have an equivalent though shall not identical mechanism, mathematically this model is equivalent to Special Relativity, and supports ALL its formulas, i.e., v < c; and $m={}m_0=\gamma m_0$, E = mc², $t={\gamma}$, that are direction-insensitive and determined by its speed, v; Critically, both spins are quantized, ℏ, Fig.3A&C; the complete Dirac’s equation of an electron is $ = +} ++ $, e.g., in an external electrical field, $|E_q|=\left|_{\perp}}}+_{//}\right| = |}{c}} + {c}}| $, $ {//}}$, Fig. 3D; therefore; $}$ is direction-sensitive and determined by its relative speed, and follows Lorentz transformation, leading to Lorentz transformation of Length; and magnetism is just electricity due to speed, a concept also applies to Bohr magneton; therefore supporting the basic Maxwell’s equations. Implications also include chirality, strong force, de Broglie wave, Fig.4, etc. The spherical model should be just an observation, as the electrical force between an electron and a proton tends to be maximized due to spins, and the electrical dipole moment, determined by the moment of inertia, $I_m=m_0R_0^2=\hbar{c}$, is nearly undetectable. We conclude this model of electron is the realization of Dirac’s insights, the only possible model that can physically explain Bohr magneton and de Broglie wavelength of an electron, and provides one step further to the ultimate Quantum Theory.
NUMERICAL SIMULATIONS OF A CURVE FLOW RELATED TO CENTRO-AFFINE INVARIANTS
YANHUA YU
FAN XIA

YANHUA YU

and 1 more

October 19, 2023
In this paper, we propose a novel numerical implementation for visualizing the evolutionary process of a curve flow. This flow is an invariant second-order flow in centro-affine geometry. The key of the scheme proposed in this essay is to indirectly obtain the position vector by solving the evolution equation of the support function. Additionally, to improve efficiency, we choose a specific tangential velocity which can eliminate the necessity to update normal angles at each iteration. The reason is that the normal angles do not change over time under this tangential velocity. Finally, we conduct multiple experiments to demonstrate the feasibility and efficiency of our proposed method.
Novel tandem passivated contact approach for high-efficiency industrial TOPCon solar...
Sheng Ma
Baochen Liao

Sheng Ma

and 16 more

October 19, 2023
Passivating contact solar cells have gradually become the mainstream cell technology due to their excellent performance, and further improving the conversion efficiency has become a focus of subsequent research. Typically, achieving excellent field-effect passivation and low contact resistivity in doped polycrystalline silicon (poly-Si) solar cells requires heavy phosphorus doping. However, this approach can lead to a predicament where excessive phosphorus diffuses into the Si substrate during annealing, causing recombination losses. To address this challenge, a tandem passivation contact structure incorporating an intrinsic amorphous silicon (a-Si ( i)) film within the passivation layers is introduced to retard the diffusion of phosphorus into the Si substrate. Comprehensive characterizations of the tandem structure were carried out to delve into the underlying mechanisms of films with the integrated a-Si ( i) layer, including simulations, surface microscopy, active dopants profiling, crystallographic structure, chemical bonding, elemental distribution, and electrical properties. Simulations revealed that the inserted intrinsic layer effectively counteracts the clustering of phosphorus atoms, leading to a more even distribution during crystal growth. Furthermore, active dopant profiles indicate the potential of the introduced a-Si ( i) layer to tailor the in-diffused dopant profile. Microscopy investigations revealed the occurrence of blistering when the a-Si ( i) thickness exceeds 30 nm. Passivation and contact performances of TOPCon solar cells were assessed as the a-Si ( i) thickness was varied. Notably, optimal electrical properties were achieved with 20 nm a-Si ( i) thickness. At this thickness, the implied open-circuit voltage ( iV OC) of the hydrogenated lifetime sample was promoted to more than 736.6 mV on the polished wafer, corresponding to the lowest single-side saturation current density ( J 0) of 4.3 fA/cm 2. In addition, a low contact resistivity of 1.4 mΩ·cm 2 was achieved. Based on this tandem passivation contact structure, industrial-sized TOPCon solar cells were fabricated, giving an average efficiency of 23.83%, 0.25% higher than that of the baseline counterparts on the production line. The above results demonstrate the role of the a-Si ( i) film as a buffer layer, retarding the diffusion of phosphorus into the Si substrate and obtaining a better passivation effect. This enables us to further tailor the doping profile for high-efficiency solar cells. Our work thus highlights a promising strategy to improve the performance of TOPCon solar cells and showcases its potential for implementation in industrial manufacturing.
Gross ecosystem product (GEP) accounting in Miyun County: supply and use
Yuqian Shen
Yi Xiao

Yuqian Shen

and 3 more

October 19, 2023
We aimed to evaluate the supply capacity and use status of the ecosystem in Miyun County. The potential and actual gross ecosystem products (GEPs), describing the background condition of an ecosystem and human demand for ecosystem products, respectively, were estimated. In 2020, the actual GEP of Miyun County accounted for 21% of the potential GEP. Water retention and climate regulation services were the highest in the potential and actual GEPs, respectively. The contributions of wetlands and forests were the highest in the potential and actual GEPs. Natural ecosystem area and vegetation coverage were the main factors affecting the potential GEP, whereas the actual GEP was mainly affected by gross domestic product (GDP) and population. Using Miyun County data, we quantitatively analysed the supply capacity and actual use of ecosystem products to clarify the interdependence between the ecosystem and human society to support decisions for regional eco-sustainability.
Comparative aspects on the epoxidation of soybean oil and high oleic soybean oil
Jacyr Vianna de Quadros
Luiz Felipe Silva Ferreira

Jacyr Vianna de Quadros

and 4 more

October 19, 2023
Soybean oil (SO) epoxidation is an extensively studied method to generate a sustainable plasticizer for polyvinyl chloride (PVC). Standard soybean oil is composed of triglycerides whose fatty acids are primarily unsaturated linoleic, oleic, and linolenic acids. High oleic soybean oil (HOSO) is collected from a soybean variety higher in oleic acid than other acids. The present study focused on a preliminary comparison of the epoxidation reaction behavior between SO and HOSO, conducted isoperibolically. The experimental data were correlated by a kinetic model. Considerable differences in the temperature and oxirane index profiles suggest that the epoxidation of HOSO tends to be faster and with a more intense heat release rate than the epoxidation of SO, which was confirmed by the results of estimated kinetic constants. The data collected and shared herein suggest that a first epoxy group generated may cause steric hindrance to slow the epoxidation in the second and third double bonds of the oil.
A comparison of early pregnancy biomarkers associated with metabolic health between I...
Esti C. DE GRAAFF
John Thompson

Esti C. DE GRAAFF

and 8 more

October 19, 2023
Objective: Increased rates of pro-inflammatory and metabolic-related disorders, plus perinatal death and other pregnancy complications such as gestational diabetes (GDM), are consistently reported among women of Indian ethnicity. This study compares lipid profiles and early pregnancy biomarkers associated with metabolic dysfunction between healthy nulliparous pregnant women of Indian and European ethnicity. Design: a prospective cohort study. Setting: Australia, Ireland, New Zealand and the United Kingdom; 2004-2011. Population: 138 and 5,240 women of Indian and European ethnicity were included from the prospective Screening for Pregnancy Endpoints cohort study. Methods: Early pregnancy biomarkers were selected a priori on the basis of a potential association with the metabolic syndrome, diabetes/GDM or obesity, and compared between ethnic groups. Biomarkers that differed significantly between ethnic groups were adjusted for maternal age, body mass index, smoking, alcohol use and socioeconomic status. Main outcome measures: Mean values for 21 placental, metabolic, inflammatory and cardiovascular biomarkers, plus blood lipids, measured at 15±1 weeks gestation. Results: Ten biomarkers were significantly different by ethnicity, mostly consistent with a pro-inflammatory and less favourable metabolic profile in Indian women: PlGF (p=0.02), adiponectin (p<0.01), NGAL (p<0.01), TNFR1A (p<0.01), CXCL10 (p=0.01), ICAM-1 (p<0.01), ST2 (p<0.01), angiogenin (p<0.01), and proANP (p<0.01). We additionally found increased triglycerides (1.6±0.6 vs 1.5±0.6, p<0.01) and reduced HDL cholesterol (1.7±0.4 vs 1.9±04, p<0.01) in Indian mothers, compared with European. Conclusions: Low-risk mothers of Indian ethnicity have an overall less favourable metabolic health profile at early gestation compared with European women. Future research should investigate the association with pregnancy outcomes.
The Global Value of Freshwater Lakes
Xingming Li
Panagiotis Tsigaris

Xingming Li

and 1 more

October 19, 2023
Lakes face threats from human activities like unsustainable development, population growth, and industrial technologies. These challenges impact the ecosystem services of lakes. Research has assessed the value of services from freshwater biomes annually. This article reviews these values, estimating lakes’ global ecosystem services to be within the region of USD 1.5 to 5.5 trillion annually. Their natural asset value is estimated at USD 100 - 337 trillion, comparable to value of global real estate, assuming a relatively high social discount rate to account for future increased standard of livings. Considering environmental degradation, future generations may experience a lower living standard. Using a 0.1% discount rate, recognizing potential harm and aligning with indigenous values, raises the lakes’ value to USD 1,500 - 5,500 trillion which is at least equal to the global value of wealth created. This valuation is shared by all, unlike the skewed distribution of created wealth.
miR-221 and Parkinson’s disease: A biomarker with therapeutic potential
Mohammad Yassin Zamanian
Mehraveh  Sadeghi Ivraghi

Mohammad Yassin Zamanian

and 11 more

July 12, 2023
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to various motor and non-motor symptoms. Several cellular and molecular mechanisms such as alpha-synuclein (α-syn) accumulation, mitochondrial dysfunction, oxidative stress, and neuroinflammation are involved in the pathogenesis of this disease. MicroRNAs (miRNAs) play important roles in post-transcriptional gene regulation. They are typically about 21-25 nucleotides in length and are involved in the regulation of gene expression by binding to the messenger RNA (mRNA) molecules. miRNAs like miR-221 play important roles in various biological processes, including development, cell proliferation, differentiation, and apoptosis. miR-221 is also implicated in promoting neuronal survival against oxidative stress and in promoting neurite outgrowth and neuronal differentiation. Additionally, the role of miR-221 in PD has been investigated in several studies. According to the results of this study; 1) miR-221 protects against oxidative stress in 6-hydroxydopamine-induced PC12 cells; 2) miR-221 prevents Bax/caspase-3 signaling activation by stopping Bim; 3) miR-221 has moderate predictive power for PD; 4) miR-221 directly targets PTEN, and PTEN over-expression eliminates the protective action of miR-221 on p-AKT expression in PC12 cells; 5) miRNA-221, by manipulating the Akt signaling pathway, performs in controlling cell viability and apoptosis in PD. This review study suggests that miR-221 has the potential to be used as a clinical biomarker for PD diagnosis and stage assignment.
Quantifying convergence and consistency
Nicholas J. Matiasz
Justin Wood

Nicholas Matiasz

and 2 more

October 27, 2023
The reproducibility crisis highlights several unresolved issues in science, including the need to develop measures that gauge both the consistency and convergence of data sets. While existing meta-analytic methods quantify the consistency of evidence, they do not quantify its convergence: the extent to which different types of empirical methods have provided evidence to support a hypothesis. To address this gap in meta-analysis, we and colleagues developed a summary metric—the cumulative evidence index (CEI)—which uses Bayesian statistics to quantify the degree of both consistency and convergence of evidence regarding causal hypotheses between two phenomena. Here we outline the CEI’s underlying model, which quantifies the extent to which studies of four types—positive intervention, negative intervention, positive non-intervention, and negative non-intervention—lend credence to any of three types of causal relations: excitatory, inhibitory, or no-connection. Along with p-values and other measures, the CEI can provide a more holistic perspective on a set of evidence by quantitatively expressing epistemic principles that scientists regularly employ qualitatively. The CEI can thus address the reproducibility crisis by formally demonstrating how convergent evidence across multiple study types can yield progress toward scientific consensus, even when an individual type of study fails to yield reproducible results.
Functional connectivity and temporal dynamics of EEG in novice meditators: Associatio...
Ren Guerriero
Stephen Dundon

Ren Guerriero

and 5 more

October 19, 2023
Background Coherence analysis examines the functional connectivity of cortical regions, which are important for cognitive functioning and may be related to the benefits of meditation. Meditation analysis to date has analyzed coherence by comparing EEG wave power using Fast Fourier Transform (FFT), and then calculating the coherence spectra with disregard to wave phase. This method can show spurious coherence between regions that are unlikely to be synchronized. Our methods used a phase synchronization measure of coherence, mean phase coherence (MPC) - novel to meditation. Methods Attentional performance before and after 20-minute eye-closed focused attention meditation was measured in 25 healthy, meditation naïve subjects. MPC was calculated in wave specific bins and for every 30 seconds during meditation. To determine if these EEG hallmarks showed relation with performance changes, MPC and power was then correlated to PVT results. Results MPC showed high alpha coherence between front-temporal and frontal-occipital electrodes. Meditation also underwent temporal changes with high prefrontal gamma coherence correlated with better performance at meditation onset, with frontal alpha and beta power later in the meditation. Alpha coherence throughout the meditation was correlated with better attentional performance changes. Conclusions Our data suggest that MPC may have identified regions of high coherence during meditation that are correlated with improved PVT performance. The results also suggest that meditation is a dynamic neural process that requires more careful analysis into temporal changes. Finally, results suggest that “control” conditions need to be more systematically studied, as many conditions may show similar neural dynamics to meditation
Effectiveness of Corticosteroid Therapy in COVID-19 Induced Olfactory Dysfunction: a...
Syed Muhammad Mehdi Zaidi
Shozab Naeem

Syed Muhammad Mehdi Zaidi

and 10 more

October 19, 2023
Introduction: Covid-19 has been strongly associated with the loss of smell also known as anosmia. It is one of the first symptoms experienced by patients who encounter covid-19. The condition has been reported to have a detrimental impact on psychological and emotional well-being, physical health, and relationships thus compromising the quality of life. Various reasons have been proposed to justify the cause of anosmia, with apoptosis of olfactory cells and inflammation of the mucosa amongst a few. The following study aims to shed light on the efficacy of intranasal corticosteroids in the treatment of these conditions.  Methods: From their inception to 20 May 2023, a complete search of electronic databases including PubMed, MEDLINE, Scopus, and Cochrane was conducted to look for studies consisting of data regarding short-term or long-term anosmia in COVID-19 patient populations who were treated using intra-nasal corticosteroids.After a rigorous process of study selection, 7 studies were shortlisted and utilized to conduct a meta-analysis. Results: The improvement in the olfactory score at 2 and 4 weeks was statistically higher in the treatment group (Standard Mean Difference [SMD]= 1.01 [0.07, 1.94], p-value= 0.03) as compared to the control group (SMD = 1.25 [0.78, 1.73], P = 0.00004). However, the results in the 4 weeks group were not significant. Similarly, the effect of corticosteroids in patients in whom anosmia lasted for more than 4 weeks also turned out to be insignificant (SMD = 0.51 [-0.12, 1.14], a p-value of 0.11, I2 =78%). According to the subgroup analysis, there were no significant differences in the efficacy of corticosteroids in short and long-term anosmia (RR = 1.26 [0.83, 1.92] and 1.57 [0.04, 70.02], p-value = 0.13).  Conclusion: As per the findings of the meta-analysis, corticosteroids do play a role in the improvement of the olfactory dysfunction caused by COVID-19. However, there was no difference in their efficacy for the treatment of short-term versus long-term anosmia patients.
ABIapp: A user-friendly tool for precise parasitic helminth species delimitation
Abigail Chan
Urusa Thaenkham

Abigail Chan

and 3 more

October 19, 2023
Parasitic helminths are highly diverse and ubiquitously distributed in various environments and hosts. Their vast species diversity makes both morphological and molecular species delimitation challenging. We developed and validated a simple, easy-to-use application, Applying Taxonomic Boundaries for Species Identification (ABIapp), to aid in the delimitation of helminth species. ABIapp utilizes a database of cut-off genetic distances determined by the K-means algorithm to establish helminth taxonomic boundaries for the 18S and 28S rRNA genes, ITS1 and 2 regions, and the 12S and 16S rRNA, COI, COII, cytB, and ND1 genes. ABIapp is written in R, using the Shiny framework to deliver an interactive and user-friendly interface. To assess the accuracy of ABIapp, validation was undertaken both in silico and with actual specimens. In silico validation involved obtaining 591 genetic distances from 117 publications and inputting these into ABIapp, while actual specimen validation was conducted using ten specimens. We also compared the accuracy of ABIapp with other species delimitation servers. We achieved an overall classification accuracy of 76 % and 75 % for in silico and with actual specimens, respectively. Our results underscore the effectiveness and reliability of ABIapp for helminth species delimitation. With its user-friendly interface, minimalistic data input requirements, and robust classification accuracy, ABIapp is a pioneering tool offering helminth researchers an invaluable resource for species delimitation.
Plant Mitochondrial Genome Map (PMGmap): A Software Tool for Comprehensive Visualizat...
Xinyi Zhang
Hai-Mei Chen

Xinyi Zhang

and 6 more

October 19, 2023
Genome visualization tools are important for exploring genomic features and their interactions. Currently, visualization of the plant mitochondrial genomes (mitogenome) depends on those tools designed originally for animal mitogenomes and plant plastomes. These tools cannot faithfully present features unique to the plant mitogenomes, such as non-linear exon arrangement for genes, prevalence of functional non-coding features, and complex chromosomal architectures. To address these challenges, a software package plant mitochondrial genome map (PMGmap), was developed using Python programming language. PMGmap can draw genes at exon levels, draw cis- and trans-splicing gene maps, draw non-coding features, draw repetitive sequences, scale the genic regions using a scaling the genic regions on the genome (SGM) algorithm, and draw multiple chromosomes simultaneously. We compared PMGmap with other leading tools on 405 plant mitogenomes and found that PMGmap allowed the visualization of the above-mentioned features better than those tools. We believe PMGmap will become an invaluable tool for plant mitogenome research. The web and container versions and the source code of PMGmap can be accessed at http://www.1kmpg.cn/pmgmap.
Experimental study of horizontal casing deformation with different perforation design...
Hun Lin
Song Xixiang

Hun Lin

and 4 more

October 19, 2023
Deep shale gas has the characteristics of deep reservoirs, including large differences in in-situ stress and complex fracture distribution. During fracturing operation, deep horizontal casing is more prone to damage and deformation than medium-shallow casing. In this study, large-scale true triaxial hydraulic fracturing casing deformation experiments were carried out using three-dimensional optical imaging and scanning to extract the casing deformation information, and the effect of different perforation factors on horizontal casing deformation was studied. The experimental results show that when a certain threshold angle is reached between the perforation direction and direction of maximum horizontal principal stress, shear deformation will occur only at the perforation along one side of the casing, and the deformation will be relatively large. Furthermore, when the perforation direction is parallel to the direction of the maximum horizontal principal stress, shear deformation will occur at the perforations along both sides of the casing, but the deformation will be relatively small. After reducing the distance between perforations, the squeezing forces on both sides of the casing become unbalanced, and the casi­­­­­­­­­­­­­­­ng is more likely to suffer from bending deformation. After reducing the number of perforations, the casing is subjected to greater shear energy at the perforations, resulting in an increase in the shear deformation of the casing. This findings indicate a direction for design and engineering of more robust horizontal casings, thereby contributing to better risk and safety management of deep reservoir hydrocarbon extraction.
Esophageal Tuberculosis as a Rare Cause of Dysphagia: Case Report
Billy Zhao
Hyun Jae Kim

Billy Zhao

and 5 more

October 19, 2023
Introduction:Gastrointestinal tuberculosis (TB) is a rare extrapulmonary manifestation of TB.1 Involvement of terminal ileum, cecum, and peritoneum are more commonly documented while esophageal involvement accounts for less than 0.2% of all TB patients.2-4 Despite the lower incidence of TB in Western countries, given the vague clinical manifestations of gastrointestinal TB, clinicians are required to keep TB on their differentials in work-up of various gastrointestinal symptoms, even if the patient has been previously vaccinated. We present a unique case of esophageal and duodenal TB in a patient who was vaccinated with BCG, with a prior negative Mantoux tuberculin skin test (TST).
Advancements in Neovascular Ophthalmopathy: Therapeutic Strategies and Future Prospec...
Miaomiao Zhang
Xinyue Lu

Miaomiao Zhang

and 6 more

October 19, 2023
Abnormal ocular angiogenesis is a key factor in the development of many blinding ocular diseases, including wet age-related macular degeneration (wAMD), diabetic macular oedema (DME), pathologic myopia with choroidal neovascularization (PM-CNV), and neovascular glaucoma (NVG). The development of anti-neovascular drugs and ocular drug delivery systems (DDS) offers more possibilities for the treatment of neovascular eye diseases. In addition to anti-vascular endothelial growth factor (anti-VEGF) agents, the discovery of other anti-angiogenic targets, such as somatostatin, endostatin and pigment epithelium-derived factor (PEDF), has been a boon to patients with poor anti-VEGF efficacy and led to a reduction in the adverse effects of long-term VEGF inhibition. Gene therapy is currently a very promising approach for the treatment of neovascular ophthalmopathy. The rapid development of gene therapy and the potential for viral vector-mediated gene delivery to achieve sustained expression of anti-vascular substances at the lesion site will mitigate the risks associated with frequent intraocular injections for patients. This review provides an overview of several neovascular ophthalmopathies, discusses the use of anti-vascular therapeutic agents and common DDS, and summarizes treatment strategies and future perspectives for neovascular ophthalmopathy.
The pathogenesis of Acute Exogenous Lipid Pneumonia based on proteomics
Tingting Weng
Huamin Wang

Tingting Weng

and 8 more

October 19, 2023
Introduction Acute exogenous lipoid pneumonia (AELP) is a rare disease. At present, the specific pathogenesis of AELP is unclear, and there is no safe and effective specific drug. The purpose of this study is to explore the biological processes, signal pathways and key proteins involved in AELP through proteomics, bioinformatics and polymerase chain reaction, so as to deepen the study of the pathogenesis of AELP. Methods The experimental rats were randomly divided into 2 groups: experiment group (inhaled 0.5 ml/kg of sewing machine oil) and control group (inhaled 0.5 ml/kg of normal saline). Collect the proteins in the upper lobe of the right lung of mice for proteomic sequencing to obtain the expression data, use the differential analysis software MaxQuant to screen the differentially expressed proteins (DEPs), and use the bioinformatics analysis method to carry out gene ontology function (GO), Kyoto Encyclopedia of genes and genomes (KEGG) analysis and protein-protein interaction (PPI) network construction for DEGs, Eleven key proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, DEFB4, F3, MK167, SLC39A4, LIMD1 and GJA1) were detected by Reverse-transcription polymerase chain reaction (RT-PCR) for validation. Results A total of 1253 DEPs were obtained after comparing the data of the experimental group and the control group with the proteome, including 843 up-regulated proteins and 410 down-regulated proteins. Through the functional analysis of GO and KEGG, it is found that these DEPs mainly participate in the regulation process of integrin binding, proteoglycan binding, chemokine receptor binding, receiver regulator binding, and cytokine activity, and are significantly enriched in proteoglycan binding and other signal pathways. PPI network construction was carried out for DEPs to screen out proteins with high correlation, such as ACTN3, CX3CR1, CCR3, AGT, MYLPF. 11 proteins were verified by RT-PCR,compared with the control group, 9 proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, MK167, SLC39A4, LIMD1 and GJA1) were significantly up-regulated in the experimental group. Conclusion Our findings identified that PADI4, IGF2, UHRF1, DEFB4 and GJA1 proteins may be potential diagnostic biomarker of AELP.
UNUSUAL GIANT PLUNGING SUBLINGUAL EPIDERMOID CYST: A CASE REPORT AND REVIEW OF LITERA...
MOHAMAD SAFWAN A
Arens Jean Ricardo Médéus

MOHAMAD SAFWAN A

and 6 more

October 19, 2023
A document by MOHAMAD SAFWAN A. Click on the document to view its contents.
SPATIO-TEMPORAL CHANGE OF DISPERSAL AREAS OF GREATER KUDU (Tragelaphus strepsiceros)...
BEATRICE CHESEREK
George  Ogendi

BEATRICE CHESEREK

and 2 more

October 19, 2023
Wildlife populations decline of 69% between 1977 and 2016 have been reported in Kenya’s rangelands. Baringo County experienced over 85% wildlife loss in the last four decades, and thus a major concern for wildlife conservation, food security and environmental sustainability. Greater Kudu (Tragelaphus strepsiceros) is endemic to Lake Bogoria landscape in Baringo County and constitutes a major tourist attraction for the region. In an area with limited dispersal opportunities, the range for this species is crucial for its survival. To a large extent, extinction of wild animal species has been attributed to habitat degradation that directly affects dispersal areas. This study was carried out to assess spatio-temporal change of dispersal areas of Greater Kudu (GK) in Lake Bogoria landscape in the last four years for enhanced conservation and improved livelihoods. GK population distribution primary data collected in December 2022 and secondary data acquired from LBNR for 2019 and 2020 were digitized using ArcGIS. Measures of dispersion and point pattern analysis (PPA) were used to analyze dispersal of GK population using a Geographic Information System (GIS). It was evident that GK dispersal in LBNR has been changing thus the null hypothesis that spatio-temporal distribution of dispersal areas of the GK in Lake Bogoria landscape did not change in the last four years was rejected. It was recommended that anthropogenic activities contributing to GK habitat degradation be curbed by providing alternative livelihood sources and enhancement of adoption of sustainable technologies including use of solar energy and climate-smart agriculture by local communities.
Scleritis Following the booster shot of inactivated COVID-19 (Sinopharm) Vaccine in a...
Kimia Jazi
Mahnaz Rahimi

Kimia Jazi

and 4 more

October 19, 2023
Scleritis Following the booster shot of inactivated COVID-19 (Sinopharm) Vaccine in a 52-year-old WomanKimia Jazi1, Mahnaz Rahimi1, Fatemeh Hasani2, Maryam Shirmohammadi1, Maryam Masoumi3*1Student Research Committee, Faculty of Medicine, Medical University of Qom, Qom, Iran2 Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran3 Clinical Research of Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran
Linagliptin induced acute generalized exanthematous pustulosis
Cristian Arevalo-Mojica
Daniel Arboleda-Palacios

Cristian Arevalo-Mojica

and 2 more

October 19, 2023
Acute generalized exanthematous pustulosis is a severe skin reaction, Usually begins in the first 48 hours after exposure to the culprit drug, however it can occur a few days after exposure. Its usually associated to beta-lactam antibiotics, macrolides, and quinolones, but few cases have been associated with oral antidiabetic drugs. Herein
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