Citation: Giacobbe, D.R.; Di Bella, S.; Dettori, S.; Brucci, G.; Zerbato, V.; Pol, R.; Segat, L.; D'Agaro, P.; Roman-Pognuz, E.; Friso, F.; et al.

Mohammad Reza Movahed,1,21. Department of Medicine, University of Arizona Sarver Heart Center, Tucson, AZ12. Department of Medicine, University of Arizona, Phoenix, Phoenix, AZ 2Correspondence to:Mohammad Reza Movahed, MD, PhDClinical Professor of MedicineUniversity of Arizona Sarver Heat Center1501 North Campbell AvenueTucson, AZ 85710Email: rmova@aol.comTel: 949 400 0091Key words:Chronic total occlusion; percutaneous coronary intervention; angioplasty; CTO; stenting; stent, coronary artery disease, atherosclerosis; interventionConflict of interest: None,

A document by Jose A. Martínez. Click on the document to view its contents.

A document by Jarrod Sopniewski. Click on the document to view its contents.

A document by Xinghua Yu. Click on the document to view its contents.

The selection of a food supplier involves multiple criteria, making the decision-making process complex and uncertain due to the presence of many unmeasurable and conflicting factors. To address this, this study proposes an integrated methodology that utilizes the advantages of interval numbers in dealing with complex and uncertain problems. Specifically, we suggest using the best-worst method (BWM) and the TODIM (an acronym in Portuguese for interactive and multiple attribute decision making) technique in an interval numbers environment. We introduce a new approach called interval best-worst method (IBWM) which employs interval preference degree and interval weight, and based on this, we propose the group interval BWM (GIBWM) method. Additionally, we present a novel interval TODIM (I-TODIM) method that is computationally simple, avoids the two paradoxes of the traditional TODIM method, and provides a clearer and more accurate interpretation of rankings. Furthermore, we suggest a geometric probability-based method for calculating preference and a preference-based method for calculating distance between two intervals. The method proposed in this paper has been validated by the food supplier selection problem based on real data and opinions from management experts and purchasing officer. We also conduct sensitivity and comparative analyses and discuss the effectiveness and advantages of our method. Index Terms-Group interval best-worst method (GIBWM), multiple criteria decision making (MCDM), interval TODIM method (I-TODIM), food supplier selection (FSS)

A document by Joseph Adeabah. Click on the document to view its contents.

Energetic electron losses by pitch-angle scattering and precipitation to the atmosphere from the radiation belts are controlled, to a great extent, by resonant wave particle interactions with whistler-mode waves. The efficacy of such precipitation is primarily controlled by wave intensity, although its relative importance, compared to other wave and plasma parameters, remains unclear. Precipitation spectra from the low-altitude, polar-orbiting ELFIN mission have previously been demonstrated to be consistent with energetic precipitation modeling derived from empirical models of field-aligned wave power across a wide-swath of local-time sectors. However, such modeling could not explain the intense, relativistic electron precipitation observed on the nightside. Therefore, this study aims to additionally consider the contributions of three modifications – wave obliquity, frequency spectrum, and local plasma density – to explain this discrepancy on the nightside. By incorporating these effects into both test particle simulations and quasi-linear diffusion modeling, we find that realistic implementations of each individual modification result in only slight changes to the electron precipitation spectrum. However, these modifications, when combined, enable more accurate modeling of ELFIN-observed spectra. In particular, a significant reduction in plasma density enables lower frequency waves, oblique, or even quasi-field aligned waves to resonate with near $\sim1$ MeV electrons closer to the equator. We demonstrate that the levels of modification required to accurately reproduce the nightside spectra of whistler-mode wave-driven relativistic electron precipitation match empirical expectations, and should therefore be included in future radiation belt modeling.

The "Student Information Management System" is prepared or operates to maintain the records of student in school as well as in college. Student Information Management System deals with the all the activities done by computers such as registration admission process online , and staff and class management etc all these process are handled by the computer management system. The student record can be maintained online for the distance accessible to the entire student and their parents. Without the student management system managing and maintaining the details student is tedious job for any organization. Student information system will store all the detailed of the students including their background information, educational qualifications, Personal details and all the information related to their resume. Suppose we have 1000 of student from this we have to search a particular student we know the name of the student. In a manual system it is a tedious task through we know the name of student but using the module we can easily search the student by specifying the name of student in the search criteria. Thus module will help the administrator in searching the student with the various criteria. This student management system also contained the registration module and account management. This module will help the student get registered from anywhere if the internet is present. This module really simplifies the works on paper registration. Also after successful registration the user can update information and changed their password as when required This student management system also contained the user module. This module will help administrator enabling and disable a user account and change their password when they required.

A document by Abhishek Bansal . Click on the document to view its contents.

A document by Thomas F Heston. Click on the document to view its contents.

A document by Thomas F Heston. Click on the document to view its contents.

Brief methodological description. The workflow consists of three primary steps (Figure 1): DNA extraction and enzymatic digestion, which yield the 2′-deoxyribonucleoside adducts and unmodified 2′-deoxyribonucleosides, follow the established protocol \cite{Gorokhova2020}. For extraction, we recommend a fast and easy method using Chelex 100,  an ion exchange resin \cite{Walsh2013}, that yields a high amount of DNA  \cite{Phillips2012}. If short, Chelex 100 suspension is added to the sample, heated to release nucleic acids, and the supernatant is used for digestion. The enzymatic digestion by nuclease P1, snake venom phosphodiesterase I, and alkaline phosphatase yields the 2′-deoxyribonucleoside adducts and unmodified 2′-deoxyribonucleosides \cite{Gorokhova2020}. The samples can be stored at −20 °C until analysis by LC-HRMS/MS.    Liquid chromatography HRMS analysis and data processing, including low- and high-mass adduct detection \cite{Martella2023}, quantification and identification using open-source databases \cite{La2022,Guo_2020}. Typically, reversed phase chromatography coupled to an Orbitrap HRMS instrumentation can be used for this purpose, employing data-dependent acquisition with an inclusion list or data-independent acquisition. The resulting high-resolution accurate mass (HRAM) data allows for increased selectivity due to the ability to differentiate the adduct ion signals from isobaric background ions. The accurate mass measurements further provide sufficient information to determine the molecular formula of the adduct analytes, which are useful in the structural characterization of the adducts. Open-source software for peak screening of the DNA adducts is available \cite{Sousa2021} for non-targeted detection of DNA adducts based on characteristic neutral loss (deoxyribose moiety, 116.0474 Da) and without any prior knowledge of the adducts. To reduce false positives, data filtering is performed using retention time alignment, accurate mass window, MS/MS fragments and any associated metadata available. The output data are normalized peak areas for specific adducts that can be used for the downstream statistical evaluations (Figure 2). The data format is typically a matrix, with adduct relative abundance and samples (i.e., individuals) given in columns and rows or vice-versa. Statistical analysis for the DNA adductome of each sentinel species used for monitoring purposes should include the following steps: (1) screening the output data to exclude non-varying adducts; (2) identification of the background variability; and (3) evaluation of the test samples against the background variability (i.e., reference state). However, currently, there are no established methods for deriving environmental quality standards from the omics data \cite{Henke2023,Machuca-Sepúlveda2023,Ebner2021}; therefore, different approaches should be evaluated and compared using data for different species and environmental settings. .

El amianto es un material ampliamente empleado en todo el mundo debido a su resistencia física, química y térmica, y a su bajo coste de producción. Sin embargo, la toxicidad de las fibras que se desprenden supone un riesgo importante para la salud humana, por lo que desde hace años está prohibida su producción y comercialización en un gran número de países.  El objetivo de este trabajo es exponer la problemática del amianto como residuo, así como describir las diferentes alternativas de valorización. Para ello hemos descrito marco legal español, así como la gestión de su reciclado, tanto en la valorización como en su depósito en vertedero autorizado.

A document by Krishnaprasad Chirakkil. Click on the document to view its contents.

A document by Katinka Bellomo. Click on the document to view its contents.

With urbanization, anthropogenic water vapor emissions have become a significant component of the urban atmosphere. Fossil fuel combustion-derived vapor (CDV) is a primary source of these emissions. Owing to the notably low CDV d-excess, stable hydrogen and oxygen isotopes are promising for distinguishing CDV from natural sources. Considering the limitations of in situ observations, this study aims to explore the feasibility of using IsoRSM, an isotopically enabled regional atmospheric model, to simulate CDV emissions in urban areas in winter. Two experiments were conducted: one in Salt Lake City in January 2017 and another in Beijing in January 2007. The simulation results showed that the CDV addition significantly reduced the water vapor d-excess, particularly when the boundary layer was stable. The simulation with CDV emissions aligned better with the time series of in situ observations in Salt Lake City. The modification led to a more pronounced positive correlation between vapor d-excess and specific humidity, which was similar to the observation of Salt Lake City. The CDV inclusion significantly increased the vapor d-excess variability with varying wind directions in both sites. However, in Beijing, the underestimation of d-excess variation from natural sources caused a bigger discrepancy between the observed and simulated d-excess and CDV fraction. Thus, though there were still biases, the inclusion of CDV could improve the accuracy of isotopic simulation in the urban regions where CDV was one of the controlling factors of vapor d-excess.

The effect of the glutathione molecules as a possible inhibitor was investigated on the nanozymatic activity of the enzyme-like carbon dots.  The peroxidase-like activity of carbon dots was proved via catalysis of peroxidase-mediated oxidation of TMB as a standard peroxidase substrate. The experimental investigations exhibited that the peroxidase-like activity of the carbon dots was significantly inhibited by glutathione molecules. Hence, the inhibitory effect of glutathione molecules on their nanozymatic activity was evaluated, revealing that the relative activity of nanozymes was inhibited by increasing the glutathione concentration in the reaction media, revealing a strong inhibitory effect of glutathione molecules on the nanozymatic activity of the enzyme-like carbon dots.

The purpose of this note is to analyze the work done by Haldar and Andersson [1]. Haldar and Andersson [1] have extended the work of Chaturani and Ponalagusamy [2] by taking into the account of axially variable plasma layer thickness. It is pertinent to pinpoint out here that in the case of two-layered model (Casson-Newtonian) for blood flow through a stenosed artery, the analytic expression for flow rate in the core (central) region is a function of axially variable plug core radius (p R) but it becomes dependent on the constant plug core radius (0 r) for the same flow in the artery with no stenosis (uniform artery). It is, in the present analysis, observed that the computation of the axially variable plasma layer thickness from the resultant equation is impossible as it depends on the two unknown parameters p R and 0 r. Hence, the method of computing the axially variable plasma layer thickness is invalid suggested by Haldar and Andersson [1]. Discussion and Conclusion Haldar and Andersson [1] have extended the work of Chaturani and Ponalagusamy [2] by taking into the account of axially variable plasma layer thickness. It is of importance to point out here that when we consider the flow of Casson's fluid (fluid having yield stress) through a

A document by Bieito Fernández Castro. Click on the document to view its contents.

“Operational Renaissance: Harnessing AI for Enhanced Business Efficacy” is a detailed exploration of Artificial Intelligence’s (AI) transformative impact on business operations. It particularly focuses on three domains: Supply Chain Management, Fraud Detection, and the Human-AI workforce relationship. The paper presents a thorough analysis of how AI is revolutionizing supply chain logistics, enhancing fraud detection methods, and reshaping the dynamics between humans and AI in the workplace. It emphasizes AI’s role in predictive analytics, real-time monitoring, and collaborative robotics, showcasing the technology as a pivotal element in modern business strategy and operations.

A document by Moshe Segal. Click on the document to view its contents.

The National Disability Insurance Scheme (NDIS) was developed to respond to the high demand for disability assistance in Australia. Created to provide information and connections to services to give people with a disability choice and control over their specific needs and supports. The NDIS has been praised with positive feedback and is heading in the right direction, but as with any government scheme, there are a few flaws and areas for improvement. There is widespread market failure in Ballarat and Victoria due to inadequate NDIS pricing for providers, inadequate funding for supports and deficit-based assumptions about people.There are several concerns (figure 1) about the NDIS for service providers that are essential to enable sector growth, employee development and support recruitment and retention by offering decent, competitive employment conditions for Disability Support Workers (DSW).

The Impact of NDIS pricing on Ballarat Disability Providers - AliceJane WebbWe need to firstly understand the policy making environment in order to influence the NDIS/NDA funding knowing who has the power to make decisions and changes is key, develop a well-defined understanding of the issues in order to create a clear unified solution and then advocate and lobby for new NDIS prices and a new Multi Enterprise Agreement. Gaining the attention of policymakers is complex, being able to simplicity present the problem and solution can ease any confusion around the issues raised (Cullerton et al., 2016).We need a proficient and successful NDIS market for disability support services that include:Quality frameworks for servicesFinancially viable for all three stakeholder groupsTraining and development for service provider employeesFair and effective enterprise agreement for service provider employeesTransparent pricing and calculationsEducation/advocacy for clients with a disabilityOur advocacy project will try to achieve these six key areas through a communication strategy that involves social media, talking with politicians, writing journal articles, talking at conferences and supporting other service providers and advocacy groups to join in.Look at his through the stages of the critical reflection model- deconstruct, confront, theorise, and think otherwise (Ramachandran, 2017), each stage of the model has an intention.The four stages look at a critical evaluation of the issue and advocacy strategy. The first two stages look at the meanings and discourses in applying the solution (Henderson & Noble, 2015). The final two staged assist in reconstructing through thinking about other evidence and possibilities on similar and differing topics (Thomas, 1999).The four stages assist in critically rethinking and reflecting academically whilst working through the possible issues and concerns with the implementation (Gur-Ze’ev, Masschelein & Blake, 2001).To deconstruct the issues and practices including problems of practice within this stage we try to understand the various perspectives that exist (Bartesaghi et al., 2018). This requires pulling apart analysis of what has or might happen in practice, especially practice that is taken for granted or have become normalised. Prior to the National Disability Insurance Scheme (NDIS), the disability sector had a different structure with three main groups of stakeholders, the customer who pays the bills (government agencies such as the Department of Health and Human Services), consumers who require the services, people with a disability (PWD) and the service providers who design and provide services for the consumers. The NDIS saw changes in many areas, mainly in the government role from the customer who paid the bills for the consumers, to the regulator and policy maker causing several perspective changes (DSS, 2012 & NDIA, 2019). The following table outlines the stakeholders as they are presently and their relevant perspectives and goals.The government perspective of the NDIS is focused on the best possible services for PWD with the least expense and maintaining that Australia wide (DHHS, 2016, & NDIA, 2018). The client perspectives include a service that supports their individual needs, quality of life improvement and freedom to choose and make informed decisions (NDIA, 2019 & DHHS, 2016). Service providers want to look after their employees through training, development, ethical and safe working conditions, to stay financially viable and provide the best possible cost-effective services to PWD (Foster, 2019 & Hubbard, 2019 & Jaworski et al., 2018). With three differing perspectives and goals it is difficult to come together and design the best and most sustainable disability sector.The confronting stage looks at the three perspectives (Government, Provider and Client) and confronts the assumptions underlining practice including an examination of the historical, social and cultural contexts involved (Loja et al., 2013).