In this paper, we discuss the stabilization of a class of delayed bilinear hyperbolic system. We focus on two cases: the case where the delay occurs in the bilinear control and the case where the delay acts on the state. First, we show existence results under certain assumptions for the considered systems. Second, we design for each system a bilinear control guaranteeing exponential stability under Lipschitz nonlinear perturbation. For the first system, the proof of stability is based on Lyapunov’s abstract functional, while for the second system we prove an equivalence between the stabilization of the delayed system and the observability of the corresponding undamped system. Examples that fall within our abstract framework are presented.

Wastewater is not only a problem but also a precious source of water that has to be utilized wisely to solve the issue of the water crisis. Prior efforts have been done towards wastewater treatment and recycling, however, more solutions still required eliminating the water crisis over the entire world. As known, modernization increases water crisis problems over time that's why scientists need to introduce new insights and materials to offer alternative approaches for the treatment of wastewater to be ready for usage to face the high demand for water in industry, agriculture, etc. Nanotechnology has played a magic role in the last decades in the treatment of wastewater by shaping materials into several morphologies such as particles, rods, spheres, fibers, etc. These morphologies have higher surface areas and pore-sized structures in comparison with bulk materials which lead to their great efficiencies and adsorption capacities. However, new ideas and insights need to be incorporated for better solutions with fewer cost properties. This review sheds the light on what has been done on the nanotechnological scale, the materials utilized and the efficiencies achieved. It may open new approaches and insights for researchers and scientists to find new methods and materials for effective contaminants elimination and water recycling.

Mechanisms related to ecological or sexual selection have favoured sympatric speciation events in African and Central American lake cichlids. Allopatric divergence is the predominant speciation process observed in Amazonia, although, to the best of our knowledge, no study to date has attempted to determine whether speciation process could exist under sympatric conditions in Amazonian cichlids. The Apistogramma agassizii species complex is an excellent model for investigating the existence of sympatric divergence events in the Amazon, as it shares many common life history characteristics with African Haplochromine cichlids in which sympatric speciation mechanisms are well documented. The genetic structure of A. agassizii was analysed by genotyping 889 individuals with ten microsatellite loci, collected from 26 sites distributed among small streams in 11 micro-basins in a very small portion of the Peruvian Amazon. It revealed 22 genetic populations identified according to panmictic criteria (FIS estimator) and strongly differentiated: FST estimator (0.034 to 0.356). Such a strong genetic structuring on such small geographical areas has never been demonstrated before in an Amazonian fish. Several of these populations may have diverged sympatrically and repeatedly in small stream networks. The results are discussed with respect to divergence processes, including sympatric speciation, that may be associated with the observed genetic structure.

Previous soil history and the current plant hosts are two plant-soil feedbacks that operate at different time-scales to influence the structure soil bacterial communities. In this study, we used a MiSeq metabarcoding strategy to describe the impact of five Brassicaceae host plant species, and three different soil histories, on the structure of their bacterial root and rhizosphere communities at full flower. We found that the Brassicaceae host plants were consistently significant in structuring the bacterial communities. Four host plants (Sinapis alba, Brassica napus, B. juncea, B. carinata) formed nearly the same bacterial communities, regardless of soil history. Camelina sativa host plants structured phylogenetically distinct bacterial communities compared to the other hosts, particularly in their roots. Soil history established the previous year was only a significant factor for bacterial community structure when the feedback of the Brassicaceae host plants was weakened, potentially due to limited soil moisture during a dry year. Understanding how plant-soil feedbacks operate at different time-scales and are involved in how microbial communities are structured is a pre-requisite for employing microbiome technologies in improving agricultural systems.

Prediction of CFPP for biodiesel based on fatty acid methyl esters composition is the focus of the presented research. A total of 90 fuel samples were derived from the literature and an additional 10 fuel samples were obtained through experimentation in order to provide an initial data set for predictive model development and training. The adaptability of RBFNN in predicting the CFPP of biodiesel is discussed, and the prediction performance compared with MLR and BPNN. When using MLR, BPNN and RBFNN for predicting CFPP of biodiesel, results demonstrated a R2 of 0.9273, 0.9990 and 0.9999, respectively. By subsequently calculating the performance evaluation index of the model, the RBFNN model's RMSE, NRMSE and SSE are the closest to 0 compared to the other two techniques. Based on the outcome of this study, these techniques can be effective tools for predicting CFPP of biodiesels, with RBFNN showing the most promise.

We present a case of a pediatric patient presenting with gastrointestinal symptoms found to have acute appendicitis and ultimately diagnosed with acute promyelocytic leukemia (APL). He had severe hemorrhage at presentation, with laboratory abnormalities concerning for disseminated intravascular coagulation, initially attributed to infection. Prior to initiating standard therapy used to treat APL, he required stabilization and numerous blood product transfusions. He was treated with all-trans retinoic acid (ATRA) and arsenic trioxide and ultimately went into remission. We present this case as there is limited literature regarding APL manifesting with gastrointestinal symptoms in pediatric patients.

Objective: Sentinel lymph node biopsy (SLNB) has emerged as an alternative to complete lymph node dissection (PPALND) in the management of endometrial cancers. The referenced data is published from high-volume specialized institutions and PPALND is still performed by many at smaller, non-specialized centers. Our aim is to demonstrate that SLNB is feasible, reproducible, and sensitive without affecting cancer-specific outcomes when implemented at a non-specialized center. Setting: Patients with clinical stage I endometrial cancer were reviewed from 2016 through 2020. Population: A total of 92 patients were included: 69 stage IA, 12 stage IB, 3 stage II and 8 stage III. Endometrioid (73%), followed by UPSC (15.0%), MMMT (5.0%) and CC (4%). Methods: Endometrioid, uterine papillary serous (UPSC), malignant mixed mesodermal tumor (MMMT), and clear cell (CC) histologies were included. Complete PPALND was performed for patients with MMMT, UPSC or CC. Sentinel lymph nodes (SLN) were evaluated using ultra-staging protocols. The medical record was queried for evidence of recurrence. Results: A total of 92 patients were included: 69 stage IA, 12 stage IB, 3 stage II and 8 stage III (2 IIIA, 2 IIIC1, 4 IIIC2). At least one SLN was detected in 95.4% of cases. The bilateral SLN detection was 74.3% and improved from 2017-2019: 70%-80%. Non-SLN were positive in 3 patients, all with high-risk histology. There have been no recurrences to date. Conclusions: Our results are comparable to the rates reported in literature and demonstrate that when applied at non-specialized centers this approach is safe and reproducible. Funding: None

In this paper, by using the contraction mapping principle, we establish the existence and uniqueness of solutions for the fourth order $p$-Laplacian beam equations $(\Phi_{p}(u’‘(t)))’‘=f(t, u(t), u’(t), u’‘(t))$ with integral boundary conditions $u’‘(0)=u’‘(1)=0,u(0)-\alpha u’(0)= \int_{0}^{1}g_{1}(s)u(s)ds, u(1)+\beta u’(1)= \int_{0}^{1}g_{2}(s)u(s)ds$. The monotony of iterations is also considered. As an extension, we obtain the uniqueness and iterative solutions of the fourth order $p$-Laplacian integral boundary value problems with fully nonlinear term $(\Phi_{p}(u’‘(t)))’‘=f(t, u(t), u’(t), u’‘(t), u”’(t))$. At last, some examples are presented to illustrate the main results.

General methods to quantize reference frame transformations, to a “superposition of coordinate transformations” have been previously introduced on an array of recent observations developed through gravitational amplification of primeval density fluctuations generated in the exceedingly early phase of cosmic evolution. In this paper, we strongly combine machine learning characteristics to Quantum Kerr- (A) dS-Myers–Perry black microBlackHole-Inspired Gravitational for both Euclidean and Lorentzian signatures in Practice. I provide algorithms by means of mean percentile free energy ranking, in a new recall-based evaluation metric for the generation of an anti-COVID-19 small molecule combination of RoccuffirnaTM, RoccuttirnaTM, and EplerotiffirnaTM anti- (nCoV-19) ligands. In this paper, I show that the notion of entanglement and superposition are observer-dependent features in quantum circuit reference frames including Galilean trans formation, and near-horizon symmetries ranging from supergravity theories to Lorentzian cryptographic signatures to enhance the RoccuffirnaTM’s gravity to trap the SARS-COV-2 viruses in practice.

In order to adapt to the stress of various environmental conditions such as high temperature, high salinity, hypoxia, and tidal flooding, mangrove plants have evolved a series of structural and physiological characteristics, and formed unique water use mechanisms and salt management strategies. This paper briefly describes the salt adaptability characteristics of mangrove plant Avicennia marina in morphological structure, physiology and ecology, including water transfer characteristics, water and salt management strategies, activation of antioxidant pathways, and focuses on the action mechanism of osmotic regulation on salt tolerance of Avicennia marina on the genetic and genomic level in recent years. The main characteristics of salt adaptation in mangroves are preliminarily revealed, which provides a new breakthrough point for further research on the molecular mechanism of mangroves adaptive evolution.

Avian influenza (AI) H5N1 viruses are zoonotic agents that cause high mortality rates in humans and poultry. In this study, some molecular characterizations and phylogenetic analysis of Hemagglutinin gene of H5N1 isolates seen in our country in 2006 were performed. Thus, it is aimed to determine the pathogenicity levels of those available isolates and whether they have the ability to transmit from person to person and establish the evolutionary relationships to some other viruses circulated in Europe, Asia and Africa. In the scope of the study, seventeen H5N1 isolates that were isolated from various Avian species were used. After the isolates were regenerated and produced in specific pathogen-free (SPF) embryonated chicken eggs, chorioallantoic fluids of the eggs were collected and RNA extraction was made, and the enzyme cleavage and receptor binding site of the hemagglutinin gene was replicated using RT-PCR. After this process, the enzyme cleavage site of the Hemagglutinin genes and the amino acid sequence of the receptor-binding site were determined by the BioEdit program. As a result, it was determined that all the seventeen isolates are High Pathogenic AI viruses. In addition, the sequence analysis of the receptor-binding site indicated that seventeen isolates did not have any mutations in the relevant amino acid positions. Also, our isolates were classified as clade 2.2 and clade 2.2.1 and were closely related to European and Asian isolates. Moreover, it is found that our isolates are not capable of transmitting from person to person; However, due to the virus traits, it has been concluded that the molecular and antigenic characteristics of the virus should be determined in places where the disease occurs since it is still circulating in some parts of the world and can be transported with migratory birds.

Perioperative immediate hypersensitivity reactions are serious but rare clinical problems that require further evaluation for possible drug allergy. Hypersensitivity reactions and medication errors are types of adverse drug reactions. Here we present a case of two perioperative hypersensitivity reactions in a single patient due to hypersensitivity to neuromuscular blocking agents, the second of which was a medication error, and the possible circumstances that led to such outcomes.

The research on the periodic change of dry-wet has significance to study the regional response research of climate change. In the ecotone between agriculture and animal husbandry along the Great Wall of China，The ring width index of the Carya Cathayensis is fitted with the rain-factor index (R) calculated by the nearest Qinglong meteorological station. The R is divided into different cycles by the stepwise function fitting method. The results show that there are two dry cycles and one wet cycle from 1543 to 2019. In each dry and wet cycle, there are also different cycles, such as long (decade years), intermediate (ten years) and short cycles (several years). Drought is a greater threat to agricultural production in the region and even China. In the first dry cycle (1543-1756), 4 cycles (1633-1635: R = 30, 1636-1939: R = 26, 1640-1642: R = 9 and 1643-1645: R = 24) with low R appear continuously, the severe droughts (R < 20, no rain in a year) last 13 years. The cycles of dry-wet changes are consistent with the traditional Chinese calendar. The results can be used to make necessary preparations for effectively coping with the drought and flood.

Some endolithic microbes, such as aerobic green algae and anaerobic bacteria, can synthesize nutrients in their coral host’s skeleton that the host relies on. Previous studies have found that the endolithic microbial constitution of a single coral species can have biogeographical diversity. However, the potential environmental factors related to the endolithic microbes remain unclear. In this study, we used both amplicon sequence variants (ASV) and a kmer-based taxonomic unit (KTU) to characterize the endolithic bacterial constitution of Isopora spp. located in the western Pacific Ocean—where it is subjected to the Kuroshio Current (in Okinawa, Japan and Green Island, Taiwan)—and the South China Sea (Dongsha Atoll). The endolithic bacterial community compositions showed a significant difference across geologies, and we suggest that the ocean current and primary productivity are the most essential environmental factors influencing the bacterial communities in the skeleton of Isopora spp. In addition, our results showed that, technically, compared to ASV, bacterial composition based on KTU avoids extreme data, making it a suitable tool for explaining the relationship between microbes and environmental factors.

Background: Fractures are one of the major health problems in the older population, having a significant impact on overall health, and quality of life. Fracture liaison services (FLS) are recommended as a model of best practice. Aims: To determine the effectiveness of implementing an FLS. Design: This was a quality improvement study set in our facility in Ain Shams University hospitals. Methods: We compared fracture care and outcomes before and after the implementation of FLS in terms of time to surgery, length of stay, pre-and postoperative pain scores, depression, and treatment decisions. We included 130 patients, aging above 60 years presenting by fracture to the emergency department. Results: We found that there was a significant reduction in the median time to surgery in the post FLS group (p value < 0.001), and also a significant decrease in the mean length of stay in favor of the group post FLS, with p value < 0.001. But there wasn’t a significant difference between the two groups regarding the number of patients that underwent surgical correction, pre-and post-operative pain, or susceptibility to depression. Conclusion: Since the beginning of our FLS unit, the preliminary data have been encouraging, with significant reductions in time to surgery and length of stay. Because there is poor patient compliance to post-discharge follow-up, we were not able to accurately measure time to medical clearance and return to previous activity and functional levels.

Objective : Adverse effects are leading causes of treatment failure with antiepileptic drugs(AEDs).We studied the cosmetic effects of AEDs and their association with medications adherence and quality of life . Methods : The study was performed on Sudanese epilepsy patients attending Daoud charity (June-September2014).Five main variables were used(1)Cosmetic effects profile;(2)Morisky Medication Adherence Scale(MMAS-8);(3)WHO Quality of Life Brief-26;(4)Socio-demographic data,and (5)Epilepsy related data. A senior neurologist assessed the cosmetic effects through clinical examination of the patients. Consents have been obtained from all patients. Results: Out of 420 patients male were (54.15%) and female were (45.85%),mean age 34.1+-10.4 years. Hair loss was the most commonly reported cosmetic effect by female patients (75%) who were taking sodium valproate.(26.2%)of patients had weight gain and none of them thought weight gain is an adverse effect. Neither of life score, nor adherence score were correlated with any of the cosmetic effects of AEDs (P>0.05).A significant positive correlations was found between the duration from the last attack and the quality of life score (P=0.03). The Gum overgrowth was correlated with hirsutism and Acne(P>0.05). Significance : We concluded that our patients prioritize medications intake in spite of the presence of cosmetic effects, and this-together with absence of association between quality of life and the cosmetic effect-may be attributed to different Sudanese patients perception to these cosmetic effects from other populations in addition to the unique Sudanese culture.

Objective: We compared birth injuries for vaginal (VD) and caesarean section (CS) deliveries in preterm and term pregnancies. Study design: 10-year retrospective study of singleton pregnancies delivered after 24 0/7 weeks, in a single tertiary center, between January 1st, 2007, and December 31st, 2017. Multivariable analyses compared trauma at birth, birth hypoxia and birth asphyxia in term and preterm deliveries, stratified by mode of birth, VD versus CS. Results: The incidence of preterm deliveries was 10.9 %. Delivery of preterm babies by CS increased from 37.0% in 2007 to 60.0% in 2017. The overall incidence of all birth trauma was 16.2 %. When stratified by mode of delivery, birth trauma was recorded in 23.4 % in vaginal deliveries and 7.5 % in CS deliveries (aOR 3.3, 95 %CI 3.1-3.5). Incidence of trauma at birth was higher after 28 weeks gestation in VD compared to CS (28-31 weeks, aOR 1.7, 95 % CI 1.3-2.3; 32-36 weeks, aOR 4.2, 95 % CI 3.6-4.9; >37 weeks, aOR 3.3, 95% CI 3.1-3.5). There was no difference in birth trauma before 28 weeks gestation between VD and CS (aOR 0.8, 95% CI 0.5-1.2). Conclusion: CS is not protective of injury at birth. When all types of birth trauma are considered, these are more common in VD, thus favoring CS as preferred method of delivery to avoid trauma at birth. However, when stratified by severity of birth trauma, preterm babies delivered vaginally are not at higher risk of major birth trauma than those delivered by CS.

Objective: The objective of this study was to assess the potential of the use of asynchronous tele-expertise (ASTE) to provide prenatal diagnosis from a medical and economic point of view. Population: Patients screened by a midwife at a primary center. Methods: A technical and clinical evaluation was conducted retrospectively, and a cost minimization study compared asynchronous tele-expertise to face-to-face consultations that would have been performed without ASTE. Main outcome measures: In our study we assessed the feasibility of TEAS, what were the origins of the requests for expertise, whether patients need to be moved and the reasons for doing so, and the costs of tele-expertise and conventional consultation. Results: In this retrospective analysis 322 advices from 260 patients were interpreted remotely via a platform. The results revealed a 90.68% feasibility of transmitting in a satisfactory and interpretable way ultrasound images and videos via the tele-expertise platform (292/322 files). In our series, asynchronous analysis allowed the required physician to make an accurate diagnosis and identify 74 (28.5%, 95% CI [23% –33.9%]) pregnancies associated with malformations and rule out abnormalities in 186 (71.5%, 95% CI [66.1% –77%]) of the cases. Asynchronous analysis prevented the displacement of 72.7% (189/260) patients. The practice of ASTE would result from a societal point of view, an average saving of \euro 123.40 per patient. Conclusion: The use of asynchronous tele-expertise (ASTE) using fetal ultrasound, is feasible and may contribute to increased diagnostic accuracy while generating a significant reduction in costs for society. Funding: None

Background：Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature infants that involves pulmonary vascular development disorder as the main pathological feature; hyperoxia is its main etiology. Twist1 strictly controls the development of blood vessels via the Tie2-Angs signaling axis. However, previous research on Twist1 mainly focuses on various tumors; its effect on BPD has yet to be reported. The present study represents the first investigation of the role and related mechanisms of the Twist1-Tie2-Angs signaling pathway in hyperoxia-induced endothelial cell injury. Methods: Primary human umbilical vein endothelial cells were used as an in vitro model. A Twist1 inhibitor (harmine) was applied to normal and hyperoxia-exposed endothelial cells. Then, we observed the permeability and tubule formation ability of endothelial cells after reducing Twist1 protein. Results: Hyperoxia increased the permeability of endothelial cells and decreased tubule formation ability. Under physiological conditions dominated by angiogenin 1 (Ang1), reducing the expression of Twist1 increases the permeability of endothelial cells and reduces tubule formation ability. In contrast, under hyperoxia conditions dominated by angiogenin 2 (Ang2), reducing the expression of Twist1 reduced the permeability of endothelial cells and increased tubule formation ability. Conclusion: Twist1 depends on the balance of Ang1 and Ang2 to control the permeability and tubule formation of endothelial cells. Reducing the levels of Twist1 may be a protective mechanism for BPD.

we identified a molecular effector mechanism of the lncRNA uc.375 in lung tissue of BPD using lncRNA microarray, bioinformatics, and functional studies. We found that uc.375 is mainly distributed in AEC II, and low expression in BPD mice AEC II. Silencing uc.375 promoted the apoptosis of MLE 12 cells, reduced their proliferation and differentiation, and promoted the apoptosis-related factor caspase 3, inhibited the expression of MLE 12 specific secretion SP-C, bcl2 and UCP2. On the contrary, after overexpressing uc.375, the opposite results were obtained. Silencing uc.375 while silencing FoxA1 inhibited MLE 12 apoptosis, promoted their proliferation, inhibited apoptosis-related factor caspase3, and promoted the expression of MLE 12-specific secretions SP-C , bcl2 and UCP2. On the contrary, overexpression of uc.375 and FoxA1 at the same time, the result is opposite. uc.375 negatively regulates FoxA1 expression, affects alveolar development, and plays an important role in the occurrence and development of BPD. In summary, this study clarified the exact mechanism of uc.375 in the occurrence and development of BPD. we identified that it may provide a new molecular target for the prevention and treatment of BPD.

Airway manifestations of inflammatory bowel disease are rare in pediatrics. This case describes a nine-year-old female with ulcerative colitis (UC) with progressive stridor and dyspnea for two months. Severe upper airway obstruction was noted on spirometry. CatScan (CT) scan of the neck and chest revealed tracheal narrowing with circumferential, heterogeneous soft tissue thickening and posterior wall nodularity. Bronchoscopy visualized granulation tissue of the large airways and an ulcerative lesion to the right mainstem. Consultation and evaluation by gastroenterology, oncology, and rheumatology determined a diagnosis of extraintestinal manifestations of UC. Systemic steroids led to symptom resolution and improvement in lung function.

Aim: To assesses the severity and prognosis of pediatric acute respiratory distress syndrome (PARDS) based on a chest radiograph (CXR) scoring method. Methods: 116 PARDS and 463 CXRs were selected. General demographics, pulmonary complications, and 28‐day mortality of the patients were recorded. Subgroup divided by prognosis (survive, death) and etiology (infection, non-infection). CXR scores were calculated for each of the four quadrants by infiltration extent (0-4) and density (1-3). The ROC curve and survival curve were established, the cut-off score for predicting prognosis was set. Results: The agreement between two independent observers was excellent (ICC=0.98, 95%CI:0.97-0.99). The hospital length of stay of death group was shorter than survive group, whereas the percentage of pulmonary complication of death group were significantly higher than survival group (all p<0.05). Day 3 score was independently associated with better survival (p<0.001). The aera under the curve of ROC was 0.773 (95%CI:0.709-0.838). The cut-off score was 21 (sensitivity 71.7%, specificity 76.5%), OR was 9.268 (95%CI: 1.257-68.320). The pulmonary complication showed an OR of 3.678 (95%CI: 1.174-11.521) for the prediction. Conclusions: CXR score can be used in PARDS for predicting prognosis and has a great agreement among radiologist and pediatrician. Pulmonary complication, Day 3 score whether greater than 21 points have a strong predictive effectiveness.

Background Environmental, socioeconomic and genetic factors all are associated with respiratory diseases. ABO blood group may contribute to the underlying susceptibility to respiratory diseases. Our study aims to investigate the association between the ABO blood groups and the susceptibility to respiratory diseases and the subsequent severity of the diseases. Methods We constructed a large retrospective cohort study of blood donors in Shaanxi, China, to investigate the impact of the ABO blood group on the risk of hospitalisation due to respiratory diseases. Reasons, duration and discharge status of hospitalisation were collected between January 1, 2012, and December 31, 2018. Results Of 1,686,263 enrolled participants (680,788 females), 26,597 were admitted to hospital for respiratory diseases. Compared with blood group O, blood groups A, B and AB all demonstrated a higher risk of diseases of the upper respiratory tract (ICD10: J30-J39) (ARR 1.139 95% CI [1.106–1.225]; 1.095 [1.019–1.177]; 1.178 [1.067–1.30], respectively) and the highest ratio was observed in participants of blood group A aged ≥55 years (1.456 [1.038–2.042]). Conversely, blood group A was found to have a lower risk (0.86 [0.747–0.991]) in influenza (J09-J11) and blood group B was lower for pneumonia (J12-J18) (0.911 [0.851–0.976]) when compared with blood group O. The duration of hospitalisation was significantly different across the blood groups in J09-J11 and J30-J39 (P<0.05). No significant difference was observed in the discharge status across blood groups. Conclusions The blood group appears to be a prognostic factor in differentiating the occurrence of specific respiratory diseases and duration.

Zika virus is an arthropod-borne virus that transmitted through various mosquito vectors and containing structural and non-structural proteins in their genome assembly. It is an emerging infectious disease causing very serious complications such as Microcephaly in infants and Guillain–Barré syndrome in adults. After analyzing the previous studies, we have targeted the NS2B-NS3 protease that serves as an effective drug target owing to its role in viral replication and immune evasion within the host. The main objective of the study is to find out the best compound(s) against ZIKA virus that can inhibit the transmission cycles as well as the replication process. We have subjected selected 20 Flavonoids from various Origanum species found in the Mediterranean regions and performed pharmacological analysis using SwissADME followed by the Molecular Docking studies using AutoDock Vina 4.0. The best hit compound after docking analysis were subjected to molecular dynamic simulation at 100 ns using Desmond Schrodinger to analyze the stability of molecule. After pharmacological analysis and molecular docking analysis, Isovitexin and Cirsiliol were observed to be best hit compound against NS2B-NS3 complex i.e. (-8.8 kcal/mol and -8.5 kcal/mol). Both the hit compounds were subjected to dynamic studies where they also exposed the better stability with the complex and inhibiting the replicating molecules observed through ligand-protein contacts. In the present study, we recommend both the hit compounds for in vitro and in vivo study for further investigation with respect to ZIKA virus.