Ewing sarcomas (ESs) and primitive neuroectodermal tumours (PNETs) exhibit identical genetic and histological characteristics, hence collectively denoted as ESs/PNETs, originating from the neuroectoderm and primarily consisting of primitive neuroectodermal cells. PNETs occur primarily in the cerebrum. They constitute 3-5% of all paediatric brain tumours. This case report describes two cases of intracranial central PNET with negative IHC and chromosomal markers in adult patients treated with craniospinal irradiation (CSI) and focal radiotherapy boost with concurrent and adjuvant chemotherapy.