Case Series of Intracranial Central Primitive Neuroectodermal Tumor in
Two Adults Treated with Craniospinal Irradiation
Abstract
Ewing sarcomas (ESs) and primitive neuroectodermal tumours (PNETs)
exhibit identical genetic and histological characteristics, hence
collectively denoted as ESs/PNETs, originating from the neuroectoderm
and primarily consisting of primitive neuroectodermal cells. PNETs occur
primarily in the cerebrum. They constitute 3-5% of all paediatric brain
tumours. This case report describes two cases of intracranial central
PNET with negative IHC and chromosomal markers in adult patients treated
with craniospinal irradiation (CSI) and focal radiotherapy boost with
concurrent and adjuvant chemotherapy.