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A. V. Vorobyev
A. V. Vorobyev

Public Documents 1
High Dynamic Range of GC MS using Orthogonal Injection into Multi-Reflecting Time-of-...
A. V. Vorobyev
Yu.I. Khasin

A. V. Vorobyev

and 4 more

August 23, 2024
Gas chromatography-mass spectrometry (GC-MS) is a cornerstone technique for analyses of semi-volatile compounds, constantly evolving to meet new challenges. The adoption of Time-of-flight mass spectrometers (TOF MS) has enhanced GC-MS with faster spectral acquisition and broader mass coverage, enabling rapid GC separations and even faster two-dimensional GCxGC analyses. Multi-reflecting TOF MS (MRT) further improves resolution compared to traditional TOF MS, facilitating the detection of minor analytes within complex matrices. This paper presents a significant improvement in MRT sensitivity and dynamic range achieved through a strong ion beam compression within the ion guide and the use of a conventionally oriented orthogonal accelerator. Sensitivity is improved to 100,000 ion/pg at a resolution of R=25,000, enabling the detection of low fg analyte quantities within 3 μg of matrix at 10 ng/s matrix fluxes. The demonstrated linear dynamic range exceeding 6 orders of magnitude potentially enables even deeper exploration of complex mixtures, which is crucial for ultra-trace analyses and metabolomic studies.

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