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High Dynamic Range of GC MS using Orthogonal Injection into Multi-Reflecting Time-of-Flight Mass Spectrometer
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  • A. V. Vorobyev,
  • Yu.I. Khasin,
  • V.V. Makarov,
  • S.N. Kirillov,
  • Anatoly Verenchikov
A. V. Vorobyev
Mass Spectrometry Consulting Ltd

Corresponding Author:aleksey.v.vorobyev@gmail.com

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Yu.I. Khasin
Mass Spectrometry Consulting Ltd
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V.V. Makarov
Mass Spectrometry Consulting Ltd
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S.N. Kirillov
Mass Spectrometry Consulting Ltd
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Anatoly Verenchikov
Mass Spectrometry Consulting Ltd
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Abstract

Gas chromatography-mass spectrometry (GC-MS) is a cornerstone technique for analyses of semi-volatile compounds, constantly evolving to meet new challenges. The adoption of Time-of-flight mass spectrometers (TOF MS) has enhanced GC-MS with faster spectral acquisition and broader mass coverage, enabling rapid GC separations and even faster two-dimensional GCxGC analyses. Multi-reflecting TOF MS (MRT) further improves resolution compared to traditional TOF MS, facilitating the detection of minor analytes within complex matrices. This paper presents a significant improvement in MRT sensitivity and dynamic range achieved through a strong ion beam compression within the ion guide and the use of a conventionally oriented orthogonal accelerator. Sensitivity is improved to 100,000 ion/pg at a resolution of R=25,000, enabling the detection of low fg analyte quantities within 3 μg of matrix at 10 ng/s matrix fluxes. The demonstrated linear dynamic range exceeding 6 orders of magnitude potentially enables even deeper exploration of complex mixtures, which is crucial for ultra-trace analyses and metabolomic studies.
Submitted to Rapid Communications in Mass Spectrometry
14 Jun 2024Review(s) Completed, Editorial Evaluation Pending
15 Jun 2024Reviewer(s) Assigned
09 Jul 2024Editorial Decision: Revise Major
12 Aug 20241st Revision Received
12 Aug 2024Submission Checks Completed
12 Aug 2024Assigned to Editor
12 Aug 2024Review(s) Completed, Editorial Evaluation Pending
12 Aug 2024Reviewer(s) Assigned
20 Aug 2024Editorial Decision: Revise Minor
21 Aug 20242nd Revision Received
22 Aug 2024Submission Checks Completed
22 Aug 2024Assigned to Editor
22 Aug 2024Review(s) Completed, Editorial Evaluation Pending
22 Aug 2024Editorial Decision: Accept