Background and objectives: Cardiac rehabilitation program (CRP) is a multidisciplinary strategy to help cardiac patients override the complications associated with cardiac disease. Patients following Coronary Artery Bypass Graft (CABG) face a critical complication that may affect their health-related quality of life and physiological outcomes, and these programs provide a better and faster recovery from cardiac surgery within the first weeks after surgery. This study reviews the impact of cardiac rehabilitation programs on the specific outcomes among CABG patients. Methods: In this systematic review the PRISMA-2020 guideline was used. Assessment of quality of the chosen studies, using the “Consolidated Standards of Reporting Trial (CONSORT)” and Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) checklist. Eligible studies were finally included in the literature review were 8 out of the 45 records identified, (from 2010-2021). Results: The cardiac rehabilitation program showed a consistent enhancement in health-related quality of life as a primary outcome and in the physiological variables as a secondary outcome. This study of a systematic review of experimental and non-experimental studies highlights the positive impact of this type of program on health-related quality of life and physiological variables of CABG patients. Conclusion: The results have significant implications in nursing research and practice, as the data offered can be used by the stakeholders and administrators of health institutions to improve their awareness of joining CRP in the routine care of CABG patients. KEYWORDS: cardiac rehabilitation programs, experimental study, health-related quality of life, physiological variables, systematic review.