Corona virus (COVID-19)-related inflammation can promote a pro-thrombotic process and subsequent thrombosis. Right heart chambers thrombus considered an unusual location. We report a 51-year confirmed COVID-19 infection, who presented with chest pain and severe hypoxemia. Echocardiography demonstrated a large mobile right ventricle thrombus protruding into the right ventricle outflow tract. Computed tomography angiography and cardiac magnetic resonance imaging showed the extension of the thrombus into the pulmonary trunk. Continuous intravenous unfractionated heparin infusion resulted in a dramatic clinical and echocardiographic improvement.