Pratik Adhikari -

Accidental Clonidine Poisoning in a 4-Year-Old FemaleAbstract A 4-year-old female with accidental Clonidine poisoning presented with respiratory depression and deranged liver function. Early recognition and comprehensive supportive care, including respiratory support, led to a full recovery, underscoring the importance of vigilant monitoring and preventive measures in pediatric poisoning cases.Keywords: Clonidine poisoning, pediatric toxicity, respiratory depression, deranged liver function IntroductionAccidental ingestion of medications in children remains a significant public health concern globally, leading to numerous emergency department visits and hospitalizations each year. Among these, Clonidine, an antihypertensive medication also used in the management of attention deficit hyperactivity disorder (ADHD), presents a unique challenge due to its potent central nervous system and cardiovascular effects [1]. Clonidine acts as an alpha-2 adrenergic agonist, and even a small overdose can lead to severe toxicity in children, including respiratory depression and cardiovascular instability [2].In recent years, there has been an increased awareness of the potential dangers associated with pediatric exposure to antihypertensive medications. The pharmacokinetics of Clonidine in children, combined with their smaller body mass and differences in drug metabolism, can result in a higher risk of adverse outcomes when accidental ingestion occurs [3]. Although cases of Clonidine poisoning are relatively rare, the severity of symptoms often necessitates intensive medical intervention and prolonged hospital stays [4].Despite the serious risks, there is a lack of comprehensive documentation in the medical literature regarding Clonidine poisoning in the pediatric population. Previous case reports have primarily focused on the immediate clinical presentation and management of such cases, often overlooking the long-term outcomes and potential complications [5]. This case report aims to fill this gap by providing a detailed account of a 4-year-old female patient who presented with significant respiratory depression and deranged liver function following accidental Clonidine ingestion.The importance of this case lies in the demonstration of effective supportive care strategies, including respiratory support and continuous monitoring, which led to a favorable outcome. By highlighting the clinical course and management of this case, we hope to contribute valuable insights to the existing literature and guide healthcare professionals in the management of similar cases [6].