Mardini–Nyhan or LACHT (lung anomaly, congenital heart defect, and thumb anomaly) syndrome is extremely rare. The literature contains only 12 reported cases in the pediatric population. We herein describe an adult patient with this syndrome.

4 cases have been reported from a tertiary referral hospital in Tehran, of which 3 have confirmed COVID-19 infection and one has been highly suspicious. The cases describe different cardiovascular presentations that can be linked to COVID-19 infection, including myocardial infarction, in-stent restenosis, myopericarditis and tamponade, and aortic dissection.