Homozygous FANCM variant c.5101C>T p.(Gln1701*) in a patient with early onset breast cancer, chemotherapy toxicity, and chromosome fragilitySonja Sulkava1,2*, Anna H. Hakonen1Minna Pöyhönen1, Heli Nevanlinna3,41 HUS Diagnostic Center, Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.2Deparment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland3HUS Diagnostic Center, Laboratory of Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.4Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.*CorrespondenceSonja Sulkava, email:sonja.sulkava@thl.fi

Facile mass transport channel and accessible active sites is crucial for binder-free air electrode catalysts in rechargeable flexible zinc-air battery (ZAB). Herein, a ZnS/NH3 dual-assisted pyrolysis strategy is proposed to prepare N/S-doped hierarchical porous bamboo carbon cloth (HP-NS-BCC) as binder-free air electrode catalyst for ZAB. BCC fabric with abundant micropores is firstly used as flexible carbon support to facilitate the heteroatom-doping and construct the hierarchical porous structure. ZnS nanospheres and NH3 activization together facilitate the electronic modulation of carbon matrix by N/S-doping and optimize the macro/meso/micropores structure of carbon fibers. Benefiting from the highly-exposed N/S-induced sites with enhanced intrinsic activity, the optimized mass transport of biocarbon fibers, as well as the ultra-large specific surface area of 2436.1 m2 g-1, the resultant HP-NS-BCC catalyst exhibits improved kinetics for oxygen reduction/evolution reaction. When applied to rechargeable aqueous ZABs, it achieves a high open-circuit voltage of 1.516 V and a significant peak power density of 249.1 mW cm−2. As binder-free air electrode catalyst, the flexible ZAB also displays stable cycling over 500 cycles with a minimal voltage gap of 0.42 V, showcasing promising applications in flexible electronic devices.

A document by Wu Qi. Click on the document to view its contents.

Background: One-third of people with cystic fibrosis (PwCF) are food insecure, with profound negative implications for their health. This qualitative study explored lived experiences with food insecurity among PwCF or their caregivers and summarized their perspectives on food insecurity screening in the CF programs where they receive care. Methods: Semi-structured qualitative interviews were conducted with two groups: (1) adults with CF and (2) parents or caregivers of children with CF. PwCF or their caregivers with previously documented food insecurity were referred for participation by pediatric and adult CF programs across the United States. Interviews were recorded and transcribed, and data were coded and analyzed by two independent coders using a content-analysis approach with a constant comparative method to generate themes. Results: A total of 26 participants from 22 CF programs were interviewed. The sample included 17 adults with CF and 9 parents of children with CF. Participants were predominantly White (88%) and female (92%). Five overarching themes emerged: (1) Food insecurity among CF patients and their families is onerous; (2) Financial constraints imposed by the CF disease contribute to food insecurity; (3) Federal and state programs provide limited food assistance, and other support is minimal; (4) Shame and stigma engulf conversations around food insecurity with CF care teams; (5) Food insecurity screening in clinical settings is critical. Conclusions: Food insecurity among PwCF is invisible, but its consequences are dire. Assistance is limited, screening is inconsistent, and stigma is widespread. There is an urgent need to normalize food insecurity screening, standardize the screening process, and expand food assistance programs for PwCF.

With the advancement of intelligent clothing and textile applications, there is a surge in interest and demand for wireless textile systems. Specifically, the textile system requires integration, which involves combining active, passive, and antenna components, without affecting mobility. With recent development, wearable electronics are intended to be low-profile, lightweight, and effortlessly incorporated into everyday life. There are various options for carrying RF power around a wearable system, commonly using conventional two-wire transmission lines operating in the TEM mode. This paper considers an alternative approach using a shallow TE mode rectangular waveguide that can be used to channel the signals. Moreover, the utilization of 3D Printing Techniques is a relatively unexplored option in the current inventory of literature. The measurement results show that it holds promising promise for facilitating efficient and secure power transfer.

Introduction:Felty syndrome, also known as Chauffard-Still-Felty syndrome, was first described by Augustus Felty. It is a rare condition diagnosed in patients with longstanding seropositive rheumatoid arthritis (RA) characterized by an enlarged spleen and neutropenia (1). Neutropenia, defined as absolute neutrophil count <1500/mm, is Felty syndrome’s hallmark feature. In RA, the patient usually presents initially with arthritis, and the felty syndrome commonly develops after many years. However, in highly uncommon instances, felty syndrome can manifest before or without any signs of arthritis. Only a few case reports have been published highlighting this unusual presentation of the Felty syndrome (Table 2). We present a similar case of a young female who initially presented with felty syndrome without arthritis. This case report emphasizes the clinical and diagnostic approach to rule out alternate causes of neutropenia with splenomegaly and timely recognition of the atypical presentation of Felty syndrome.

Objective The aim of this article is to describe co-development and delivery of Policy Labs in Sierra Leone and Zambia for expedition of emerging evidence into clinical management of Pre-eclampsia. Design Co-development and delivery of Policy Labs. Setting Policy Labs were undertaken in Freetown, Sierra Leone and Lusaka, Zambia. Population Participants were purposively selected in each setting to represent a diverse range of relevant stakeholders. Methods Working with King’s Policy Institute, we co-developed and delivered two Policy Labs based on their 8-step process and the ‘trust-translation-timing’ model. Main outcome measures Policy Lab attendance; Policy Lab delivery; Policy Lab report and agreed outputs. Results Two Policy Labs were held: in Zambia (14 th February 2023) and Sierra Leone (7 th March 2023), attended by 35 and 39 diverse stakeholders respectively, included women via pre-recorded video clips. Both labs were successfully facilitated by local, well-respected female team members, and addressed co-developed questions (‘What are enablers and barriers to offering planned early delivery between 34 and 37 weeks?’ – Zambia; ‘How can we improve timely detection and appropriate action in women with Pre-eclampsia?’ – Sierra Leone) in answer to context-specific emerging evidence. Participants at both labs identified lack of Pre-eclampsia awareness as a key barrier, and recommended development of locally designed, community based strategies to increase access to timely, evidence-based Pre-eclampsia management. Conclusions Policy Labs are a novel approach to facilitate transfer of new knowledge into policy and action. Future Policy Labs should feature the women, participating in real time, at the forefront of the discussion.

Introduction: Infective endocarditis is associated with many complications; these include cardiac, metastatic, neurologic, renal, musculoskeletal, and pulmonary complications. Renal complications of IE include glomerulonephritis, renal infarction or abscess following septic embolization, and drug-induced acute interstitial nephritis.( 1) Acute renal failure, defined as a serum creatinine of ≥2 mg/dL (177 mmol/L), has been described in up to one-third of patients with infective endocarditis. Infective endocarditis can rarely be complicated by RPGN, and this poses diagnostic and therapeutic challenges. There are only a few case reports of infective endocarditis associated with RPGN in the literature. In a study of 595 IE-related RPGN, the prevalence of Infective endocarditis-related RPGN was found to be 3.4%. ( 2). These studies have also found that it was difficult to differentiate these cases from other differentials, like vasculitis. In a retrospective review of 24 cases of infective endocarditis associated with RPGN, all patients presented with fever and multi-system organ involvement. The involved organs include the heart, kidney, lung, skin, joint, spleen, lung, nervous system, and eye. (2) All of these patients presented with rapid deterioration of renal function within 1 week to several months, along with glomerular hematuria and proteinuria. The mean peak serum creatinine was 6.7 mg/dl (range 3.0–16.1 mg/dl). The most commonly involved valves are the aortic and mitral valves. All of these patients were treated with intravenous antibiotics, and some of them required surgical and immune suppressive therapies. Here we present the case of a 34-year-old known CRVHD patient for whom a prosthetic mitral valve replacement was done 14 years ago for severe mitral stenosis. The patient presented with flank pain, a decrease in urine amount, and a raised creatinine of 3 days duration. Initial workup with Tran’s thoracic echocardiography missed valvular vegetation. She was about to be started on immune suppressive therapy until repeat echocardiography revealed a 3cm by 3cm aortic and mitral valve vegetation. She was treated with intravenous antibiotics alone and diuretics, and she didn’t require immune suppressive therapy. She was discharged with improvement, and follow-up trans-thoracic echocardiography revealed resolution of the vegetation.Case presentationA 34-year-old female patient who was on follow-up for chronic rheumatic valvular heart disease, for whom a prosthetic mitral valve replacement was done 13 years ago for severe mitral stenosis, came to our hospital OPD with the complaint of flank pain of three days duration. The pain was dull and aching in type and involved both her flank areas. Associated with this, she also had reddish discoloration of the urine, a decrease in urine volume, and lower extremity swelling of the same duration. On further inquiry, she admitted that she had a low-grade intermittent fever, loss of appetite, and easy fatigability, which started during this illness period. She was taking anticoagulation and antibiotic prophylaxis. Other than the symptoms mentioned above, she had no orthopnea, PND, chest pain, or chronic medical illnesses like HIV, diabetes mellitus, or hypertension. On physical examination, she was afebrile; her blood pressure was systolic 110 mmHg and diastolic 80 mmHg; her pulse rate was 78 beats per minute; and her respiratory rate was 18 breaths per minute. Cardiovascular examination revealed a flat JVP and a Grade IV holosystolic murmur that is best heard at the apex. Further examination of the genito-urinary system showed bilateral flank tenderness, and musco-skeleton examination showed grade II pitting edema involving both extremities. We investigated her with a complete blood count, which showed a WBC of 25,000, a neutrophil percentage of 91%, and hemoglobin and platelet counts that were within normal. She had an elevated acute phase reactant (ESR: 68 mm/hr). Her serum creatinine was 8.5 mg/dl; her baseline serum creatinine was normal 2 weeks prior to our hospital visit. (Diagram 1, trend of serum creatinine). Urine analysis showed proteinuria and many red blood cells, and the 24-hour urine protein determination was 244 mg. Serology tests like ANA, hepatitis B surface antigen, hepatitis C antibody, and HIV tests were all negative. She was further investigated with a chest X-ray, which was normal, and an ECG showed features of atrial fibrillation with a fast ventricular response of 165 beats per minute (Figure 1). With the initial suspicion of Infective endocarditis, we investigated her with a blood culture and echocardiography. Blood culture had no microorganism growth. Initial transthoracic echocardiography was normal. Repeated transthoracic echocardiography revealed 3cm by 3 cm of vegetation on the aortic and prosthetic mitral valves, severe aortic stenosis, moderate aortic regurgitation, moderate mitral stenosis, severe tricuspid regurgitation, and mild pulmonary hypertension. Mild biventricular systolic dysfunction with an ejection fraction of 45% She was admitted to our hospital, and a diagnosis of rapidly progressive glomerulonephritis was made, and we planned to give her methylprednisolone pulse therapy. However, the repeated echocardiography showed vegetation over both the native valve (aortic) and the prosthetic valve (mitral valve), as described above. Later, a diagnosis of native and prosthetic Infective endocarditis complicated by rapidly progressive glomerulonephritis was made, and the plan to give pulse therapy was cancelled. For this diagnosis, we treated our patient with intravenous antibiotics and diuretic therapy. After two weeks of these treatments, flank pain and lower extremity edema subsided. Serum creatinine recovered, and the patient was discharged with improvement. She was seen on follow-up, and she was in good condition. The follow up trans-thoracic echocardiography showed aortic vegetation, which has decreased in size; otherwise, prosthetic mitral valve vegetation was not seen (Figure 2), and the follow-up serum creatinine was normal.Discussion Infective endocarditis is an infection of the endocardial surface of the heart, and it can be an infection of one or more heart valves or of the intra-cardiac devices. It is a rare disease with an estimated yearly incidence of 3–10 cases per 10,000 people (3). The term native valve endocarditis refers to a cardiac infection that involves the leaflets of the valves, the endocardial surface, chordae tendinae, congenital defects, and anastomosis sites. Prosthetic valve endocarditis (PVE) is a microbial infection of parts of a prosthetic valve or reconstructed native heart valve. (4). Patients with infective endocarditis (IE) can develop several forms of kidney disease. These include bacterial infection-related immune complex-mediated glomerulonephritis (GN), renal infarction from septic emboli, and renal cortical necrosis. Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by features of glomerular disease in the urinalysis and by progressive loss of kidney function over a comparatively short period of time (days, weeks, or a few months). The treatment we give to patients with Infective endocarditis can also lead to kidney injury. ( 5,6,7) Diagnoses of Infective endocarditis as a cause of RPGN have therapeutic implications. Most patients with RPGN need immune suppressive therapy. However, patients whose RPGN is caused by Infective endocarditis may be successfully treated with antibiotics alone and may not need immune suppressive therapy. Our patient has clinical and laboratory features suggestive of RPGN, and we planned to give immune suppressive therapy. It is not uncommon for trans-thoracic echocardiography to miss valvular vegetation. The initial echocardiography didn’t show valvular vegetation, but the repeated one showed three small-sized aortic and prosthetic mitral valve vegetations. Our patient fulfills diagnostic clinical criteria for both native and prosthetic valve infective endocarditis (8), and a diagnosis of native and prosthetic valve infective endocarditis complicated with RPGN was made. Infective endocarditis involving multiple valves has rarely been described, and there are only a few case reports of simultaneous native and prosthetic valve endocarditis. (9) Multi-valvular and simultaneous native (aortic) and prosthetic (mitral) valve involvement is what makes our patient’s presentation unique. Studies have shown that patients with Infective endocarditis-associated RPGN can be treated with intravenous antibiotics, and some of these patients may need immune suppressive therapy, particularly when kidney function does not improve after antibiotic therapy. (2) We treated our patient with intravenous antibiotics, and she showed clinical improvement, and serum creatinine showed recovery over 2 weeks. Our patient would have been subjected to immune suppressive therapy if the diagnosis of infective endocarditis had been missed.Conclusion Native and prosthetic valves Infective endocarditis may be rarely complicated by rapidly progressive glomerulonephritis. The diagnosis of Infective endocarditis may be missed, especially if the vegetation is small, as observed in our patient. Detection of infective endocarditis as a cause of RPGN may eliminate the need for immune suppressive therapy, as observed in our patient. Our case illustrates that not all RPGN require immunosuppressive therapy. So, it is important to have a high index of suspicion of infective endocarditis as a cause of RPGN in appropriate clinical conditions. Author contribution: Yitagesu Getachew: Conceptualization, Investigation, Validation, Writing – review & editing. Zerubabel Getahun: Investigation Writing – original draft. Getachew Wondafrash: Conceptualization, Supervision Validation, Zemenay Asmare: Formal analysis Writing – original draft. Gashaw Solela: Supervision, Writing – review & editing. Beka Aberra: Supervision Validation. Merga Daba: Writing – original draft ,Writing – review & editing.Data Availability Statement The data that support the findings of this case report are available from the corresponding author upon reasonable request.Ethical ApprovalThe authors’ institution does not require ethical approval for publication of single case report.Consent for PublicationThe patient’s family provided written informed consent for the publication of details including, history, physical findings, laboratory reports, and imaging.FundingNo funding was used in this case report.DisclosureWe authors have no conflict of interest.

This paper introduces how Sapphire varies from the standard conventional methodologies used for ranking YouTube Videos. By implementing Natural Language Processing, specifically Computer Linguistics, Sapphire enhances YouTube Video ranking by specifically weighing videos based on how much content they covers rather than their Statistics. The conventional Watch Time algorithm ranks videos based on features such as viewership status, likes, subscriptions, etc [Fyf20]. This Whitepaper delves into what makes Sapphire distinct and domain specific from the Watch Time Algorithm.

With the rapid growth of internet of thing (IoT) wireless devices, cooperative spectrum sensing (CSS) has emerged as a promising solution to leverage the spatial diversity of multiple IoT sensing nodes (SNs) for spectrum availability. However, the cooperative paradigm also incurs increased cooperative costs between each SN and the fusion center (FC), leading to decreased cooperative efficiency and achievable throughput, especially in large-scale cognitive IoTs (CIoTs). To address these challenges, we present a sequential detection with feedback information (SD-FI) approach in this paper. To achieve this objective, we propose a two-way CSS model that formulates an optimization problem of Bayes cost in a quickest detection framework with feedback. To solve this optimization problem, we derive the structure of the optimal local decision rule from the local decision function and determine the optimal detection threshold in conjunction with the cost function. Following the optimal threshold pair, we implement the optimal SD-FI and theoretically demonstrate the uniqueness of the optimal threshold and optimal sensing time. Simulation results demonstrate superiority of our proposed approach in terms of cooperative performance (i.e., detection performance and Bayes cost) and sample size. Notably, even with limited sensing time, our proposed SD-FI exhibits high throughput, highlighting its effectiveness in enhancing spectrum availability and utilization in cognitive IoTs.

Online distance learning policies were formulated and implemented among some Malaysian universities long ago, but their value emerged since COVID-19. Emanating from the diffusion of innovation theory, this study examined the perception of higher education students on the influence and relationship between six independent variables (compatibility, observability, relative advantage, complexity, trialability, and digital skills) and one dependent variable (digital literacy). A total of 524 respondents were sampled, comprising students from six public and private Malaysian universities. The findings from the correlation analysis show a significant positive relationship between the six independent variables and the dependent variable. Meanwhile, in the regression analysis, three of the independent variables (observability, trialability, and digital skill) have a significant and positive effect on digital literacy. This study placed the diffusion of innovation in a specific context that supports designing online distance learning and digital literacy policies.

Promising many societal benefits, emergent products of biotechnology involve releasing genetically modified microbes (GMMs) into the environment. However, regulatory challenges limit their use. So far, GMMs have mainly been tested in agriculture and environmental cleanup, with few approved for commercial purposes. Current government regulations inadequately address modern genetic engineering and limit the potential of gut therapeutics, skin products, self-repairing materials, ocean pollution treatment, anti-corrosion coatings, etc. This review first describes current U.S. regulations for engineered bacterial release. We analyze 57 global studies on soil-released GMMs and laboratory microcosm experiments. We discuss the environmental behavior of released bacteria and offer engineering guidelines to improve performance, control persistence, and reduce risk. Advanced technologies that improve GMM function and control, but lead to increases regulatory scrutiny, are reviewed. Finally, we propose a new regulatory framework informed by recent data to maximize the benefits of GMMs and rapidly address risks.

This study presents a novel approach to monitoring respiration rate using frequency modulated continuous wave (FMCW) mm-wave radar, aiming to overcome the limitations of traditional non-contact method. 14 participants were involved in an experiment involving alternating periods of stillness and left-right continuous body shaking. Data analysis involved non-negative matrix factorization (NMF) and template matching techniques. Respiration measured by radar were compared with ground truth measurements. Results demonstrated accurate respiration detection even during continuous body movement, with significant correlation observed between radar-based and ground truth measurements. This study pioneers radar-based respiration monitoring under continuous body movement conditions, offering promising implications for practical applications.

Introduction: Migraine is one of the most common complaints and is debilitating as it affects the quality of life. Triptans are considered effective and are frequently prescribed by primary physicians and neurologists. Renal infarction is rare side effect of triptans that can be misdiagnosed if not considered in patients using them (2,3). Clinical presentation of renal infarction can be misleading in some cases. We present a case of middle-aged lady, who was diagnosed with renal infarction after long-standing use of Zolmitriptan. Although, renal infarction is a rare side effect after triptans use, but it should be considered in patients who use these medications regularly.

The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to multiple waves of infections globally. As the virus continues to evolve, new variants have emerged, some with concerning changes in transmissibility and virulence. Among these variants, the ” FLiRT Variants” have recently garnered attention due to their potential to alter the dynamics of transmission and disease severity. According to the Infectious Disease Society of America, the nickname ‘FLiRT’ is based on the technical names for their mutations. The FLiRT variants, particularly KP.2, seem to exhibit heightened transmissibility in comparison to earlier Omicron sub-variants. Additionally, they demonstrate a capacity to evade immunity conferred by prior infection and vaccines, although the full extent of this evasion is still being investigated In this article, we review the characteristics of the FLiRT Variant, including its genetic mutations, epidemiological features, potential impact on public health measures, and implications for vaccine efficacy. We also discuss strategies for surveillance, prevention, and mitigation efforts to control the spread of this variant and mitigate its impact on global health.

The Yarlung Zangbo River Basin (YZRB), located in the Qinghai-Tibetan Plateau, has been dramatically affected by global warming. In recent decades, serving as the indicator of coupled vegetation growth and climate variation, the spatiotemporal land surface temperature has been changed substantially by changes in environmental factors while greening spreading. In this study, we evaluated the components of water and energy cycle during 1980-2015 based on the VIC model, one of the widely recognized and applicated distributed hydrological model. The fluctuation of LST was examined and the influence of environmental elements on LST was identified. The results showed that VIC model performed a high adaptability in applying and conducting in YZRB with R 2 over 0.7 and Er at 5.03%. Climate factors were increasing while human activities stayed stable in YZRB by our modeling. In addition, climate factors (precipitation, evapotranspiration, temperature) and underlying factors (soil moisture, NDVI, Albedo) were detected as influencing factors of LST. In YZRB, the greening was witnessed while LST showed an increasing trend. By distinguishing the climate and human activities on LST, ET and NDVI are two dominant factors effecting LST. From 1980 to 1995, LST was mainly affected by climate and its contribution rate was 70.36%. After 1995, LST was affected by human activities, and its contribution rate was 55%. Grassland with medium cover showed the potential of a cooling influence. Among all the environmental factors, Albedo showed a negative and a lagged behind effect on LST. Temp, P and ET were positively related to LST and displayed changes that are relatively in phase. SM, NDVI, were detected as leading the changes in LST, positively. Our study contributes to clarifying the mechanisms influencing LST in high-altitude and high-latitude regions under the global greening and is fundamental for socio-economic development in alpine mountainous regions.

One of the crucial and major issues in engineering, particularly in signal processing, is signal reconstruction. Frames are flexible tools that helps to reconstruct signals/vectors in a stable way. Frame theory was introduced for Hilbert spaces by Duffin et al. in 1952. If it happens that we only have the intensity measurements or the phaseless measurements of the lost signal then reconstructing the original signal becomes difficult. In such cases, phase retrieval sequences play essential roles to reconstruct or regain the signal from its intensity measurements or phaseless measurements. In 2006, Balan et al. introduced phase retrievable frames for Hilbert spaces. Phase retrieval has received significant attention in various fields, including image processing and signal reconstruction. Similar to phase retrieval, norm retrieval sequences help to regain the norm of the original signal. In 2015 Bahmanpour et al. introduced norm retrieval sequences for Hilbert spaces. We provide a thorough overview of phase retrieval and norm retrieval by vectors and subspaces in separable Hilbert space. We also highlight and discuss the recent developments in phase retrieval and norm retrieval of partially lost signals.

Indoor air quality is a key determining factor for public health, with one of the main methods of measurement being the mass concentration of particles 2.5 micrometers or smaller (PM 2.5). These tiny particles create a major health risk and lead to adverse respiratory and cardiovascular issues. This research paper investigates the impact of different cooking fuels: gas, electric, and biomass fuel, on indoor PM 2.5 exposure rates using a low-cost air quality sensor. These data help quantify the severity of certain cooking fuels and identify the most suitable fuel source. An experimental study found that electrical and natural gas fuel sources have around 600 µg/m 3 (18000%) fewer PM 2.5 concentration levels. Previous studies have identified gas stoves to release volatile organic compounds (VOCs) pollutants that also have detrimental short and long-term health effects. Moreover, this study includes potential mitigation strategies to reduce indoor PM 2.5 exposure, helping to promote healthier cooking practices. The study hopes to shed light on the potential of low-cost air quality sensors and the wider adoption of their data for air quality monitoring.

Scene cartoonization aims to convert photos into stylized cartoons. While GANs can generate high-quality images, previous methods focus on individual images or single styles, ignoring relationships between datasets. We propose a novel multi-style scene cartoonization GAN that leverages multiple cartoon datasets jointly. Our main technical contribution is a multi-branch style encoder that disentangles representations to model styles as distributions over entire datasets rather than images. Combined with a multi-task discriminator and perceptual losses optimizing across collections, our model achieves state-of-the-art diverse stylization while preserving semantics. Experiments demonstrate that by learning from inter-dataset relationships, our method translates photos into cartoon images with improved realism and abstraction fidelity compared to prior arts, without iterative re-training for new styles.

Background: Seasonal H3N2 influenza virus, known for its rapid evolution, poses a serious threat to human health. This study focuses on analyzing the influenza virus trends in Jining City (2018-2023) and understanding the evolving nature of H3N2 strains. Methods: Data on influenza-like cases was gathered from Jining City’s sentinel hospitals: Jining First People’s Hospital and Rencheng Maternal and Child Health Hospital, using the Chinese Influenza Surveillance Information System. Over the period from 2018 to 2023, 7,844 throat swab specimens were assessed using real-time fluorescence quantitative PCR for influenza virus nucleic acid detection. For cases positive for seasonal H3N2 influenza virus, virus isolation was followed by whole genome s

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A document by Jiaxin Zhang. Click on the document to view its contents.

In this study, we study translation surfaces of framed curves in the 3-dimensional Euclidean space . First, we compute some important equations and geometric invariants such as first and second fundamental forms, Gauss equations, Christoffel symbols, Mainardi-Codazzi equations and Egregium Theorema. Using these equations, we introduce some characterizations of translation surfaces of framed curves. Also, we study some special cases such as framed generating curves of the surface are framed Bertrand-partner curves or Mannheim-partner curves. MSC: 53A04, 53A05, 53A55.

This paper proves the existence of nontrivial solution for two classes of quasilinear systems of the type { − ∆ Φ 1 u = F u ( x , u , v )+ λ R u ( x , u , v ) in Ω − ∆ Φ 2 v = − F v ( x , u , v ) − λ R v ( x , u , v ) in Ω u = v = 0 on ∂ Ω where λ>0 is a parameter, Ω is a bounded domain in R N ( N≥2) with smooth boundary ∂Ω. The first class we drop the ∆ 2 -condition of the functions Φ ̵̃ i ( i=1 ,2) and assume that F has a double criticality. For this class, we use a linking theorem without the Palais-Smale condition for locally Lipschitz functionals combined with a concentration–compactness lemma for nonreflexive Orlicz-Sobolev space. The second class, we relax the ∆ 2 -condition of the functions Φ i ( i=1 ,2). For this class, we consider F=0 and λ=1 and obtain the proof based on a saddle-point theorem of Rabinowitz without the Palais-Smale condition for functionals Fréchet differentiable combined with some properties of the weak ∗ topology.