A 34 Year lady is decribed in whom a persistent left superior vena cava impinged on the posterior wall of the left atrium that accompanied with membrane at distal part of it's impingement and producing subdivided left atrium

Yuanjiang dry-hot valley is poorly vegetated as a fragile arid ecosystem. Although it was lushly forested in the past, it becomes a tropical montane savannah in recent decades. This study focus on the regime driving such a change which could help to understand the relationship between plants and their living environments in the low land of dry-hot valley, and also help to thrive the ecology policy in Yuanjiang-Red River. Plant species and their individuals are investigated in transects and plots arranging along the river channel. The first is L-transect lying along the river running direction while the second is P-transect lying perpendicular to river channel. Alpha and beta indices are employed to cope with biodiversity change in species and in environments. Expected species, rarity and abundance indices are subscribed to the correlation among species, population size, and their living circumstances, in the terms of Species_estimated, Singeltons, Uniques, ACE, ICE, and Chao2. Meanwhile, fifty years’ meteorological records in the valley including temperature and precipitation are collected for environmental references. The results indicate that: (1) in Yuanjiang dry-hot valley, alpha diversity is higher in the transects and plots closing to river channel than apart from while beta diversity increases from upper stream to the lower with Bray-Curtis < 0.500, but this condition is reversed in the transect perpendicular to the river; (2) tidal range contributes a lot in alpha biodiversity especially in the upper stream; (3) expected species, rarity and abundance indices are stronger in the sites closing to river channel and tidal range which is strongly indicating heterogeneous habitats. (4) Solanum virginianum is an ideal environmental indicator in the dry-hot valley. Conclusively, plants are not flourished in the low altitude ascribed to high temperature and poor precipitation. More attention should be laid on the micro habitat protection in our environmental management.

In this paper, we study the following Cauchy problem \begin{equation*} \left\{ \begin{array}{lll} iu_t=\Delta u+2uh’(|u|^2)\Delta h(|u|^2)+F(|u|^2)u\mp A[h(|u|^2]^{2^*-1}h’(|u|^2)u,\ x\in \mathbb{R}^N, \ t>0,\\ u(x,0)=u_0(x),\quad x\in \mathbb{R}^N. \end{array}\right. \end{equation*} Here $h(s)$ and $F(s)$ are some real-valued functions, $h(s)\geq 0$ and $h’(s)\geq 0$ for $s\geq 0$, $N\geq 3$, $A>0$. Besides obtaining sufficient conditions on the blowup in finite time and global existence of the solution, we get Morawetz type estimates and weighted spacetime bounds for the global solution based on pseudoconformal conservation law, we also establish a sharp threshold which gives the watershed for initial data $u_0$ making the solution blow up.

Objective To study clinical efficacy and quality of life of sacrospinous ligament fixation in the treatment of pelvic organ prolapse. Design Retrospective analysis of clinical cases Setting China Population or sample 124 cases of patients with pelvic organ prolapse of The second affiliated hospital of anhui medical university were retrospectively analyzed from January 2013 to December 2019. Methods Perioperative information, postoperative complications, postoperative subjective recovery and postoperative quality of life questionnaire were observed and compared. According to different postoperative follow-up time, patients were divided into the <12 months group, the 12-24 months group, the 24-60 months group and the ≥60 months group, and the subjective postoperative recovery of patients in different groups was counted respectively. Main outcome measures POP-Q stages were in normal position after 3 months of postoperation, and the values of genital hole, perineal body, and total vaginal length were significantly different from those before operation (P<0.001). The results of the pelvic floor dysfunction questionnaire for 19 patients after 12 months of postoperation showed that the total PFDI-20 score was significantly different from that before surgery (P<0.001), the preoperative and postoperative scores of UDI-6(urogenital distress inventory) and POPDI-6(pelvic organ prolapse distress inventory) were significantly different (P<0.001). Preoperative and postoperative hemoglobin difference was statistically significant (P <0.001), while preoperative and postoperative residual urine values were not statistically significant (P >0.05). Conclusion Sacrospinous ligament fixation (SSLF) has a significant effect on the treatment of moderate and severe pelvic organs prolapse, and can effectively restore its anatomical structure.

n this work, our attention is focused on $\lambda$- double almost statistical convergence of weight $h$. Mainly we work $\lambda$- double almost statistical convergence of weight $h$ and strong $\lambda$- double almost summability of weight $h$.

Objectives To compare clinical characteristics and factors predictive of resistance to initial treatment with Methotrexate-folinic acid (MTX-FA) in women with low-risk gestational trophoblastic neoplasia (GTN). Design A retrospective study Setting A tertiary center Populations Patients diagnosed with low-risk GTN. Methods: Demographic data, disease characteristics, treatment response, toxicity and data of the subsequent pregnancy were collected and analyzed. Main outcome measures Groups of patients who were responsive or resistance to treatment were compared. Stepwise logistic regression analysis was used to identify factors predictive of resistance to Methotrexate chemotherapy. Results Totally, 113 patients were eligible for analysis. The primary remission rate was 55.8% with first-line MTX-FA. All others patients achieved remission by subsequent treatment with Actinomycin D or multiple-agents chemotherapy. Relapse of disease was found in 4.4% and the overall survival rate was 99.1%. Univariate analysis showed that pre-treatment serum hCG, neutrophil-to-lymphocyte ratio at baseline, and serum hCG ratio of the first three consecutive cycles (C) were significantly associated with resistance to MTX-FA. Independent factors that predict failure to respond to first-line MTX-FA were pre-treatment serum hCG ≥15,000 IU/L (OR 3.95; 95%CI = 1.48-10.52; p=0.006), a less than 4.8-fold reduction of serum hCG between cycle 1 and cycle 2 (C1/C2) (OR 4.08; 95%CI = 1.60-10.39; p=0.003), and a less than 7-fold reduction of serum hCG from cycle 2 to cycle 3 (C2/C3) (OR 10.15; 95%CI = 3.10-33.30; p<0.001). Conclusions First-line MTX-FA treatment is effective in 55.8% of patients. Pre-treatment serum hCG, and hCG ratio between consecutive treatment cycles predicts initial treatment failure.

In this paper we deal with a Dirichlet problem for an elliptic equation involving the 1-Laplace operator. Under suitable assumptions on the nonlinearity we show that there exists a symmetrical, monotonic and positive solution via the moving plane method. We show the a priori estimates for the positive solution.

Opioids are widely being used for chronic pain management, cough and diarrhea suppressants, anesthetic agents, and opioid de-addiction therapy. Opioid receptors, present in the central nervous system and peripheral tissues, are documented to regulate several cardiac functions through different signaling pathways. Long-acting opioids (LAO) have been successfully evaluated for their beneficial effects in various cardiovascular diseases viz. myocardial infarction, ischemic reperfusion injuries, atherosclerosis etc. However, on the other hand, several research studies pointed towards the harmful effects of LAOs which are mainly associated with QTc prolongation, torsade de pointers, ventricular arrhythmias, and cardiac arrest. This review shall familiarize readers with the benefits as well as the harmful effects of long-acting opioids in cardiovascular diseases. We have also provided an overview of cardiac opioid receptors, endogenous cardiac opioid peptides, and regulation of cardiovascular functions by central and cardiac opioid receptors.

Introduction: Osteoporosis is a chronic and progressive disease caused by an imbalance in the bone remodeling process. In this process, resorption and formation are performed by osteoclasts and osteoblasts, respectively. This delicate balance is regulated by several hormones and cytokines. Thus, to attain a better understanding of the bone remodeling associated process with osteoporosis in aging subjects, the following mediators were investigated: cytokines, chemokines and metalloproteinase-3 (MMP-3). Patients and Methods: To this end, blood samples were collected from 30 osteoporotic patients, cytokines, chemokines and MMP-3 were measured with the help of ELISA and CBA. Results: Men with osteoporosis had significantly higher levels of MMP-3 and decreased levels of CCL5 than women. Women with osteoporosis had significantly higher levels of IL-33 compared to adult males. Discussion and conclusion: The different immunological factors seem to act differently in osteoporosis evaluated separately in men and women. An increase in MMP-3 and decreased CCL5 may be an important factor in osteoporosis in men, whereas the disease seems to be associated with an increase in IL-33 in women.

Purpose: The development of technologies for the prolongation of life has resulted in an increase in the number of older ventilated patients in internal medicine and chronic care wards. Our study aimed to determine the factors influencing the outcomes of older ventilated patients in internal medicine wards. Methods: We performed a prospective observational cohort study including all newly ventilated medical patients aged 65 years and older over a period of 18 months. Data were acquired from computerized medical records and from an interview of the medical personnel initiating mechanical ventilation. Results: A total of 554 underwent mechanical ventilation for the first time during the study period. The average age was 79 years, and 80% resided at home. Following mechanical ventilation, 8% died in the emergency room, and the majority of patients (351; 63%) were hospitalized in internal medicine wards. In-hospital mortality was 64.1%, with 48% dying during the first week of hospitalization. Overall 6-month survival was 26%. We found that a combination of age 85 years and older, functional status prior to ventilation, and associated morbidity (diabetes with target organ injury and / or oncological solid organ disease) were the strongest negative predictors of survival after discharge from the hospital. Conclusion: Mechanical ventilation at older age is associated with poor survival and it is possible to identify factors predicting survival. In the midst of the Covid-19 pandemic, the findings of this study may help in the decision-making process regarding mechanical ventilation for older people.

Codon optimization of foreign genes is a common method to improve protein expression level in Pichia pastoris and the current strategy usually is to replace rare codons with preferred codons to match the codon usage bias. However, codon-pair contexts have a profound effect on translation efficiency in Pichia pastoris by influencing both translational elongation rates and accuracy. Until now, it remains untested in Pichia pastoris whether optimized exogenous genes based on codon pair bias results in higher protein expression levels compared to codon usage bias. In this work, we developed Codon Pair Optimization (CPO) which is a software tool to provide simple and efficient codon pair optimization for synthetic gene design in Pichia pastoris. Two reporters (MT1-MMP E2C6 and ADAM17 A9B8 scFvs) were employed to test the effect of CPO optimization on their protein expression levels in Pichia pastoris. The CPO optimized genes displayed significantly higher expression levels compared to those based on codon usage bias, suggesting CPO is an efficient tool for synthetic gene design for higher heterologous protein expression in Pichia pastors.

Background and Purpose: Of the three primary cannabinoids in cannabis: 9-Tetrahydrocannabinol (9-THC), Cannabidiol (CBD) and Cannabinol (CBN), very little is known about the actions of CBN, the primary oxidative metabolite of THC. Our goal was to determine if CBN exposure during gastrulation alters embryonic development, and if so, via which cannabinoid receptors. Experimental Approach: Zebrafish embryos during the gastrulation stage (5-10.75 hpf) were exposed to CBN in the presence or absence of cannabinoid receptor blockers. We examined neuronal morphology, hair cell development and locomotion. Key Results: Embryos exhibited dose-dependent malformations in morphology, increased mortality, decreased locomotion and a reduction in motor neuron branching. Larva exhibited a significant reduction in the response to sound stimuli. CBN exposure altered the development of otic vesicles and hair cells associated with the lateral line. Pharmacological block of CB2Rs with AM 630 or JTE 907 prevented many of the CBN-induced developmental defects, while block of CB1Rs with AM 251 or CP 945598 had little or no effect. Conclusion and Implications: Altogether we show that embryonic exposure to CBN results in alterations in embryonic growth, neuronal and hair cell development, and physiology and behavior via CB2R-mediated mechanisms. Our results suggest that embryos exposed to CBN may be at an increased risk of abnormal development.

The majority of diabetes-related conditions occur as a result of abnormal chemical reactions in hyperglycemia that alter normal metabolic processes. Hyperglycemia is a key process in unregulated Ca2+ leakage, inflammation, and immune-system disorders, and it can lead to a number of short- and long-term health complications, including diabetic cardiomyopathy. Ryanodine receptors (RyRs) play a key role in excitation-contraction-coupling during heart contractions including rhythmic contraction and relaxation of the heart-and are important for controlling cardiac fibroblast function, are expressed in immune cells, and are involved in important mechanisms underlying diabetes-related complications. However, little is known regarding the mechanistic relationship between RyRs and immunity-related molecules in diabetes, as well as the mechanisms mediating complex communication among cardiomyocytes, fibroblasts, and immune cells. This review highlights new findings on complex cellular communications in the pathogenesis and progression of diabetic cardiomyopathy. Furthermore, we discuss potential therapeutic applications targeting RyRs and immunity-related molecules in diabetic complications.

Word embedding and deep learning methods have shown to be very effective in automated text information mining. In this work, a chemical accident case analysis method is proposed and tested based on the methods. Firstly, word vectors for the text corpus of chemical accident cases were produced based on word2vec. And then Bidirectional LSTM model with attention mechanism for text classification was constructed. Finally, case studies on the correlation analysis of the common trends of chemical accidents and automated text classification of chemical accident cases documents were performed respectively. The results revealed that the proposed method can identify common principles of chemical accidents and classify chemical accident cases. These findings highlight the feasibility of chemical accident case information mining based on word embedding through case studies. Compared with rule-based information mining, our method improves the efficiency, automation, and intelligence of information mining from chemical accident cases documents.

Response surface methodology(RSM)was used to optimize the oxidizing the omeprazole sulfide to(S)-omeprazole catalyzed by soybean pod peroxidase(SPP) in cetyltrimethylammonium bromide (CTAB)/isooctane/n-butyl alcohol/water water-in-oil microemulsions. With the initial concentration of SPP of 3200 U ml-1, the conversion of the omeprazole sulfide, the (S)-omeprazole yield and ee were 93.75%, 91.56% and 96.08%, respectively. The mechanism of asymmetric sulfoxidations catalyzed by SPP involves three concomitant mechanisms as follows:(1) a two-electron reduction of SPP-I, (2) a single-electron transfer to SPP-I and (3) nonenzymatic reactions. With 5.44% of the average relative error, a kinetic model based on the mechanisms was established, and the SPP-catalyzed reactions including both the two-electron reduction and the single-electron transfer mechanisms obey ping-pong mechanism with substrate and product inhibition, while nonenzymatic reactions follow a power law. This study has also demonstrated the feasibility of SPP as a substitute with low cost, excellent enantioselectivity and better thermal stability.

ABSTRACT: Herein, the hierarchical porous catalysts of three dimensional ordered macro-mesoporous (3DOMM) ZrO2-supported active Pd nanoparticles (NPs) were prepared by two-step methods of evaporation-induced self-assembly-colloid crystal template (EISA-CCT) and gas bubbling-assisted membrane reduction (GBMR). Ordered macroporous structure can enhance diffusion and mass transfer of soot particles; ordered mesoporous structure is beneficial to enhancing activation ability for gaseous reactants. Synergistic effect of hierarchical porous structure in the catalysts is important to improve catalytic activity for soot oxidation. Pd/3DOMM-ZrO2 catalyst exhibits the highest activity (T50=404 oC) for soot oxidation compared with the single macroporous or mesoporous structure. The catalytic kinetics of hierarchical porous Pd/3DOMM-ZrO2 catalyst for soot oxidation was systemically investigated, i.e., its reaction rate is 0.038 μmolg-1s-1 at 310 oC, which is 2.7-fold of power-type Pd/normal-ZrO2 catalyst (0.014 μmolg-1s-1). The hierarchical porous structure is a good strategy to boost catalytic activity during soot oxidation.

It is extremely desirable to develop efficient and cheap water splitting photocatalysts. An ultrahigh performance and stable water splitting photocatalyst g-C3N4/ZnCdS was prepared by simple sintering method. g-C3N4 nanosheets are evenly distributed around ZnCdS nanoparticles of 20-30 nm by forming C-S bond, which can accelerate carriers separation and reduce the carrier’s life-time from 5.5 ns to 4.10 ns. The photocatalyst has a high photocatalytic hydrogen evolution rate of 16663 μmol•h-1•g-1 under visible light illumination (λ = 400-780 nm). UV-vis absorption spectra demonstrate that their absorption range can reach to visible light edge of 539 nm. Furthermore, after three recycles of photocatalyst, the hydrogen evolution stability still remains 94%. The excellent photocatalytic performance can be attributed to the Z-scheme energy band structure formed between g-C3N4 and ZnCdS with C-S bond by sintering method. This work provides significant progress toward the synthesis of cheap Z-scheme photocatalysts for practical applications.

Crossmatch-compatible platelets and HLA-matched platelets are commonly used in management of platelet refractory patients with immune causes like anti-HLA antibodies. The two type of platelets utilized by clinicians differ in practice because of region as well as objective factors such as not establishing HLA genotypic identity. We report our experience in a pediatric neuroblastoma-associated thrombocytopenia patient with anti-HLA antibodies who received 7 random-donor platelets (random PLTs) and 7 crossmatch-compatible platelets (compatible PLTs). Exploration of compatible PLTs transfusion effect and the causes affecting the occurrence of Platelet transfusion refractoriness (PTR) to provide evidence for management of pediatric patient with anti-HLA antibodies

Phthalanilic acid (PPA), a promising plant growth regulator, has been increasingly applied to fruit and vegetable production. However, its regulation on growth and development of cowpea (Vigna unguiculata) plants is still unclear. In this study, the physiological and biochemical effects of PPA on cowpea plants were investigated under field conditions by using brassinolide as the positive control. Here, the results showed that PPA treatments exhibited positive effects on photosynthesis. Meanwhile, antioxidant enzymes including superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) were enhanced post PPA application. In addition, free proline in cowpea leaves were increased, while the relative electrical conductivity and malondialdehyde (MDA) content were decreased. Furthermore, the length, width, single pod weight of cowpea were increased, and vitamin C, soluble protein and soluble sugar content were also improved by 200 mg·L-1 PPA. Moreover, PPA treatment increased yield by 16% when applied at 200 mg·L-1. Our findings demonstrate that PPA regulates the growth and development of cowpea plants, improving the yield and quality, especially at the concentration of 200 mg·L-1. This study indicates that PPA has an application prospect in cowpea production.

Immunoglobulin G4 related disease (IgG4-RD) is a rare multisystem inflammatory disease, in which one of the main gastrointestinal manifestations is autoimmune pancreatitis (AIP) type 1. AIP type 1 is correlated with a clinical presentation of obstructive jaundice, increased serum levels of IgG4 and suggestive pancreatic findings on radiologic imaging. Histo-pathology (HP) and immune-histochemistry (IHC) examinations obtained by biopsy are the gold standard for establishing the diagnosis. Several theories tried to elucidate the correlation between IgG4-RD and pancreatic or other extra-pancreatic malignancies. There are controversial opinions whether AIP type 1 serves as a premalignant state, or whether these two conditions are coexistent. We present a patient who had clinical, laboratory, radiologic and histologic findings that were consistent with a pancreatic space occupying lesion (SOL). As a result, he underwent a Whipple operation, but the IHC findings were compatible with AIP type 1. After 1 year of remission, the patient presented with a new pancreatic SOL that was diagnosed as adenocarcinoma.

Facing to the harsh environmental constraints, natural populations of widespread plant species may express plastic response, evolve local adaptation or combine both mechanisms in order to maintain their genetic variation and pervasiveness across a wide ecological niche. Here, 79 lines representing height Tunisian populations of Brachypodium hybridum were cultivated in two contrasting phosphorus (P) availability levels and their genetic variation was investigated using forage quality traits to identify the main mechanisms governing their genetic variation. Our results revealed large variation among populations for most traits. PCA analysis showed the separation between coastal and inland populations in both P levels. Importantly, all traits revealed high heritability in both P treatments and the response of most of them to P deficiency was highly influenced by the population effect, which accounted 52.38% of the total variation, indicating strong population differentiation. However, although significant for most traits, only 18.13% of variation was attributed to P treatment, suggesting little plastic response to P deficiency. Importantly, as revealed by the lack of population*treatment effect for most traits, the plastic response was probably common to all populations. Moreover, we found that 56.99% of variation was attributed to environmental factors with distance to coastline, precipitation seasonality, and annual precipitation being the most important factors, suggesting that the strong population differentiation likely reflects local adaptation to specific environmental conditions. Contrary to the coastal populations, which were characterized by high levels of fiber-related traits levels, the inland ones displayed the high values of most energy-related traits, suggesting that these latter were characterized by relatively higher forage quality. Overall, our results suggested that the effect of local adaptation overrides the effect of phenotypic plasticity in explaining the variation of forage quality traits, which indicate a broad adaptive genetic differentiation among the Tunisian populations of B. hybridum in response to P deficiency.

We present a case of pacing-induced cardiomyopathy and an occluded left subclavian vein (SCV). The SCV occlusion was delineated in a retrograde manner from femoral venous access and bypassed through direct puncture of a collateral branch. Cardiac resynchronisation therapy was achieved through His bundle pacing, with subsequent normalisation of LV function.

In this paper, we consider the initial boundary value problem of the Klein-Gordon equation on networks. The main contribution of this work is to introduce a condition (C), and we use the concavity method to obtain blow-up solutions to this problem.

The traditional K-means algorithm is very sensitive to the selection of clustering centers and the calculation of distances, so the algorithm easily converges to a locally optimal solution. In addition, the traditional algorithm has slow convergence speed and low clustering accuracy, as well as memory bottleneck problems when processing massive data. Therefore, an improved K-means algorithm is proposed in this paper. In this algorithm, the selection of the initial points in the traditional clustering algorithm is improved first, and then a new global measure, the effective distance measure, is proposed. Its main idea is to calculate the effective distance between two data samples by sparse reconstruction. Finally, on the basis of the MapReduce framework, the efficiency of the algorithm is further improved by adjusting the Hadoop cluster. Based on the real customer data from the JD Mall dataset, this paper introduces the DBI, Rand and other indicators to evaluate the clustering effects of various algorithms. The results show that the proposed algorithm not only has good convergence and accuracy but also achieves better performances than those of other compared algorithms.