Title Page:Title: Letter to the Editor: Long-term outcomes of elderly patients receiving continuous flow left ventricular supportArticle Type: Letter to the EditorCorrespondence: 1. Saad Ahmed qureshiContact No: +92-3360135206. Email: Saadqureshi1099@gmail.comInstitute: Ziauddin medical college KarachiAddress: NHS phase 4 tower 5b flat 5/7ORCID: 0000-0003-0857-3818Co-Authors: 2. Hamid ullah khanContact No: +92-3040215080. Email: hamidullahkhan595@gmail.comInstitute: Ziauddin University karachiAddress: Plot no AS 04 sector 32-D Nasir colony Korangi no 01ORCID: 0000-0002-0938-6080Co-Authors: 3. Umer sami KhanContact No: +92-304044743. Email: Umersamikhan@gmail.comInstitute: Ziauddin University karachiAddress: B4, Block B, Gulshan-e-jamal, Rashid minhas Road, KarachiORCID: 0000-0003-0849-7915Word Count: 320

Title pageTitle: Letter to the Editor: Aortic valve repair in patients with ventricular septal defectArticle type: Letter to the editorCorrespondance : 1. Mahima KhatriContact: +92-3472651872 Email: mahimakhatri12333@gmail.comInstitute: Dow University of Health SciencesAddress: Bridgeview Karachi

Background This study aims to described the epidemiology and genotypic diversity of Human metapneumovirus (HMPV) and the impact of SARS-CoV-2 on the prevalence of HMPV in hospitalized children with Acute respiratory tract infections (ARTIs) in Beijing, China. Methods From April 2018 to March 2019 and from September 2020 to August 2021, nasopharyngeal aspirates (NPAs) from hospitalized children with ARTIs in Beijing were collected and subjected to real-time polymerase chain reaction tests for HMPV. Then genotyping, detection of 15 common respiratory viruses and clinical characteristics were analyzed on HMPV positive samples. Results 7.9% (124/1572) enrolled paediatric patients were identified as having HMPV infection, and the majority of children under the age of 5 (78.2%, 92/124), From April 2018 to March 2019. The detection rate of HMPV in spring and winter is significantly higher than that in summer and autumn. The co-infection rate were 37.1% (46/124), the most common co-infected virus were parainfluenza virus type 3 (HPIV-3). The main diagnosis of HMPV infection was pneumonia (92.7%,115/124), most patient have cough and fever. Of 78 HMPV-positive specimens, A2b (82.1%,64/78) were the main epidemic subtypes. .During the COVID-19 outbreak, Among 232 samples, only 4 cases were HMPV-positive. After statistical test, the detection rate of HMPV during the COVID-19 pandemic has decreased significantly compared with that before the epidemic (p=0.001). Conclusions HMPV is an important cause of ARTIs in children under 5 years old. Under the prevention and control of the COVID-19 pandemic, the HMPV infection of hospitalized children with ARTIs has decreased significantly.

This study reports on performance enhancement in a solar cell introducing Sb2S3 as hole transport layer (HTL)along WS2 as buffer layer. We have investigated photovoltaic (PV) characteristics by utilizing SCAPS-1D. A comparative observation on PV performances of conventional CZTS/CdS with proposed CZTS/WS2 and Ni/Sb2S3/CZTS/WS2 /FTO/Al solar cells is presented. It is revealed that “spike like” band structure at CZTS/WS2 interface having smaller conduction band offset makes it potential alternative to commonly used CdS buffer. This study also evaluates that Sb2S3 as an HTL proposed at back of CZTS enhances performances by reducing carrier recombination at back interface with appropriate band alignment. The impacts of thickness, carrier concentration of different layers, and bulk defect density in CZTS as well as defects at interfaces on performances are analyzed. The influences of temperature, work function as well as cell resistances are also explored. Optimum absorber thickness of 1.0 µm along doping of 10 17 cm-3 is selected. A maximum efficiency of 30.63% is achieved for the optimized CZTS cell. Therefore, these results suggest that Sb2S3 as HTLand WS2 as buffer layer can be employed effectively to develop highly efficient and low-cost CZTS solar cells.

This Survey was conducted in Jimma Horro (Ethiopia) to assess honey production and marketing systems in three farm hand associations were nominated by means of purposive selection systems. From each PA, 48 beekeepers (a total of 144) were deliberately nominated and questioned by pre-tested, organized forms. Outcomes of the study presented that the mean honey yield per year/colony was 7.4, 11.25, and 20.6kg for traditional, transitional and moveable frame hives, respectively. Honey marketing contributors were producers, collectors, retailers and consumers. There was no variance in price of crude honey between study locations (P>0.05) and no significance difference (P>0.05) were observed. Honey yield per hive/year was found to be low from traditional and transitional hives as compared to moveable frame hive. Thus, strong extension and practical involvement is critical for agriculturalists to use the moveable frame hives and revenue of beekeepers within the study area. This study suggested as more emphasis should incline to the bee product diversification and processing and marketing system for the sake of the higher benefit.

Cubesats have transcended mere demonstration systems to sophisticated missions which invariably require the use of deployable solar arrays for more power generation. The kinematics of deployment have considerable influence on the stability and attitude control of a satellite, especially one with such low mass as Cubesats. This work aimed to model and simulate two-wing deployable solar array, with a sun tracking tilt function for a 1-U CubeSat, with emphasis on the deployment mechanism using materials locally available in the country. The design is such that four panels attached to two wings hinged at Y and – Y directions deploy slowly and smoothly at approximately 2 seconds where the vibration decays exponentially and approaches zero. The model of all parts, as well as the computational analysis were done with SOLIDWORKS software. The system was tested for vibration and stability using the seismic mass-spring-and-damper arrangement and the Bond Graph technique was used to conduct kinematic analysis of the mechanism. A 3-D printing was generated and tested to evaluate its operational performance. The simulated results of the model were validated with the prototype outputs with an error of 0.03% in energy supply reliability, about 400% more power generated than the body mounted solar panels of same satellite specification without a significant impact on system strength and Stability.

In this paper, we consider the low Mach number limit problem for the compressible viscous micropolar fluid model based on the concept of dissipative measure-valued solutions. We prove that the dissipative measure-valued solutions of the compressible micropolar fluid model converge to the smooth solution of the incompressible micropolar system in the case of well-prepared initial data when the Mach number tends to zero.

General methods to quantize combined descriptors of both the probability and phase/current distributions in molecular electronic reference frame transformations, to a “superposition of coordinate transformations” have been previously introduced. Continuity equations for these densities are explored on an array of recent fundamental observations developed through gravitational amplification of primeval density fluctuations generated in the exceedingly early phase of cosmic evolution. In this paper, I show that the notion of vertical-equilibrium state of the vanishing current entanglement in chemical space and orbital superpositions are observer-dependent features in quantum reference frames including Galilean transformation, and near-horizon symmetries ranging from supergravity theories to Lorentzian cryptographic signatures to enhance the RoccuffirnaTM’s gravity to trap the SARS-COV-2 viruses in practice. The corresponding stationary radial Schrödinger equations with these potential energy functions are solved analytically, in the underlying information continuity equation that determines machine learning characteristics for both Euclidean and Lorentzian signatures to Quantum microBlackHole-Inspired Kerr- (A) dS-Myers–Perry black Gravitationals in an approximate scheme for zero total angular momentum. It is found that the wave functions for bound states can be expressed in terms of the Jacoby polynomial involving either the nonclassical or resultant entropy/information concepts the so called horizontal-equilibrium state, which represents the phase-transformed quantum state of a molecule, corresponding to the optimum, density-dependent “thermodynamic” phase in the near-horizon limit, with either SL(2, ℝ) or Poincaré iso(1, 1) symmetry which extends to the entire near-horizon geometry . This analytical expressions for purely vibrational energy levels of the electronic state, without an accompanying change of quantum observables, preserves the electron probability distribution but modifies its current by varying the moduli to a weakly-coupled description of a pharmacophoric system, where states with fixed conserved charges can be counted. The influence of the equilibrium-phase gravitational transformation, quantum phase density, and local entropy formalism production is examined on the continuity chemical relations for the anti-COVID-19 RoccuffirnaTM molecular equilibrium states.

This paper investigates the long time well-posedness of 2-D MHD boundary layer equation without resistivity. It is proved that if the initial data satisfies \begin{align*} \|(u_0,h_0-1)\|_{H_{\mu}^{3,0}}+\|(u_0,h_0-1)\|_{H_{\mu}^{1,2}}+\|(u_0,h_0-1)\|_{H_{\mu}^{2,1}}\le \varepsilon, \end{align*} then the life span of the solution is at least of order $\varepsilon^{-\f43}$.

The article is dedicated towards the study of fractional-order non-linear differential systems with non-instantaneous impulses involving Riemann-Liouville derivatives with fixed lower limit and appropriate integral type initial conditions in Banach spaces. First, mild solution of the system is constructed and subsequently, its existence is proven using Banach's fixed point theorem. Then, results of approximate controllability are established using the concept of fractional semigroup and an iterative technique. Suitable examples are given in the end supporting the methodology along with pointing out corrections in examples presented in previous articles.

Staphylococcal Enterotoxins sensitization and response of Omalizumab in severe atopic and non atopic asthma Nicolas Migueres1,2, Anh Poirot1, Nan Zhang ,3,4, Claus Bachert 3,4, Frédéric de Blay1 ,51: Chest Diseases Department, Strasbourg University Hospital, Strasbourg France.2: UMR 7357 Laboratoire des sciences de l’ingénieur, de l’informatique et de l’imagerie ICUBE3: Upper Airways Research Laboratory, Ghent University, Ghent, Belgium4: Division of ENT diseases, CLINTEC, Karolinska Institute, University of Stockholm, Sweden5: EA 3072, Fédération de médecine translationnelle, université de Strasbourg, 67000 Strasbourg, FranceCorresponding author: Nicolas Migueres, nicolas.migueres@chru-strasbourg.frChest Diseases DepartmentNouvel Hôpital CivilHopitaux Universitaires de Strasbourg67093 STRASBOURG CEDEXtel: 00 33 6 07 60 51 86,Total word count ( 570 words)Author Contributions: All investigators contributed to the conception and design of the study. All authors contributed to the acquisition, analysis and interpretation of the data. They provided input into the drafting of the manuscript, critical feedback, and final approval for submission of the manuscript for publication. NM is the guarantor of the final content of the manuscript.The authors have no conflicts of interest to declare.

Different responses of gut microbiota diversity affect host health in term of nutrient metabolism and disease immunity, the reason and the impact of low diversity level of giant panda needs to be studied. Therefore, to explore the impact of intestinal type and diet on gut microbiota diversity of giant pandas, we conducted a multi-species comparison (n=73), and the effects of different diets on gut microbiota function of giant panda were analyzed by PICRUSt method. The gut microbiota of giant panda was significantly lower than the same diets type herbivores and the same intestinal type carnivores. High-fiber bamboo culm diet significantly reduced the gut microbiota diversity of giant panda than bamboo shoot and leaf. The low diversity of gut microbiota led to the low nutritional metabolic function of giant panda, including energy metabolism and amino acid metabolism. These results showed that the short intestinal tract and high fiber diet caused the decrease of gut microbiota diversity of giant pandas.

Our patient is a 39-year-old male with normal baseline blood parameters who presented with COVID-19 infection, associated with neutropenia and then progressed to critical disease culminating into CSS. Based on risks and benefits evaluation, he was treated with Tocilizumab reinforced with G-CSF leading to full recovery including reversal of neutropenia.

Grassland runoff is related to soil and water conservation, but there are few related studies. In this study, a simulated rainfall experiment was carried out, and the results showed that: 1) The runoff depth increases with the increase of rainfall intensity and decreases with the increase of slope or cover, all of which can be described by linear equations; 2). Soil specific gravity, root fractal dimension and grass dry weight can explain 5.00%, 31.08%, and 6.64%, respectively;3). The NSE of the grassland erosion model established by rain intensity, flow discharge and cover is 0.700, which is 0.142 larger than that of the grassland erosion model established by rain intensity and flow discharge.The research conclusions will help prevent and control floods, improve water resource utilization and strengthen grassland erosion monitoring.

Objectives: In this study, it was aimed to evaluate the effect of beta-blocker use on left ventricular global longitudinal strain (LV Gls) in echocardiography in patients with MB (Myocardial Bridge). Patients and methods: A single-center study was conducted prospectively in which patients with coronary angiography were performed and myocardial bridging was detected between January 2019 and February 2022. A total of 100 patients (38 females, 62 males; mean age: 57.3±9.6 years; range, 32-75 years) with myocardial bridging were recruited consecutively and strain echocardiography was performed. Results: All patients in our study were followed in sinus rhythm, and there was a statistically significant difference in mean heart rate between groups I and II (p<0,001). LV Gls was found to be statistically significant in favor of group II in the comparison of group I [(-12,57)±3 vs. (-15,92)±2,9] and group II (p<0.001). Conclusion: LV Gls is positively affected in echocardiography thanks to the negative chronotropic effect obtained with beta-blocker therapy in patients with MB detected in coronary angiography.

The fractographic analysis of the fracture surface is one solution to determine the kind of failures and predict the fatigue lifetime and resistance of mechanical components under cyclic loading. In the present research, the fracture behavior of the AZ91 magnesium alloy, under stress-controlled high-cycle fatigue loading, was analyzed based on the fatigue striations on the fracture surface. At first, equations and relations were extracted with the Paris crack growth law and the space of the fatigue striations. Then, striation spacing was measured by the experimental results of the high-cycle fatigue (HCF) testing for heat-treated Mg-Al-Zn alloys, containing and non-containing rare earth elements. Finally, constants of the Paris law were calculated and calibrated. Results showed that rare earth elements addition decreased the space between the striations, and subsequently, the fatigue resistance of the AZ91 alloy increased. The reasons are extreme grain size reduction by heat-treating and formation of new Al 11RE 3 phase by rare earth elements addition. The obtained results of the predicted fatigue lifetime, in comparison to the experimental ones, the scatter band of ±1.5X demonstrated the accuracy of the recommended model by a mean error of 33%.

In conclusion, we present the case of a 23-month-old boy with severe recurrent respiratory exacerbations associated with Rhinovirus infection. Thorough testing ruled out known risk factors such as congenital anomalies, immune deficiency or coinfections. A genetic analysis was performed, which failed to determine the presence of known genetic determinants of human RV susceptibility. There are few studies regarding the possible genetic mutations which increase the risk of severe respiratory exacerbations and respiratory failure secondary to viral infections, especially those involving human RV. A deeper understanding of these mutations would improve our knowledge and help identify at-risk patients with similar phenotypes to our case.

Objective: Internal contraction monitoring during the course of labor may identify elevated intrauterine resting tone. Our objective was to assess the association between elevated resting tone during labor and neonatal morbidity. Design: Secondary analysis of a prospective cohort study. Setting and Population: Term singleton patients with ruptured membranes and an intrauterine pressure catheter in place: Tertiary care hospital, United States of America Methods. Intrauterine resting tone was calculated as the average baseline pressure between contractions. The study group had elevated intrauterine resting tone, defined as intrauterine resting tone ≥75th percentile. Main Outcome Measures: Composite neonatal morbidity: hypoxic ischemic encephalopathy, hypothermia treatment, intubation, seizures, umbilical arterial pH ≥ 7.1, oxygen requirement, or death. Results: Of the 8580 patient in the cohort, 2210 (25.8%) were included. The median intrauterine resting tone was 9.7 mmHg (IQR 7.3-12.3 mmHg). Elevated resting tone was associated with shorter median duration of the first stage of labor (10.0 hrs vs 11.0 hrs, p <0.01) and lower rates of labor induction (p < 0.01). Neonatal composite morbidity was higher among patients with elevated intrauterine resting tone (5.1% vs 2.9%, p=0.01). After adjusting for chorioamnionitis and amnioinfusion, elevated intrauterine resting tone was associated with increased risk of neonatal morbidity (aOR 1.70, 95% CI 1.06-2.74). Compared to normal tone, elevated intrauterine resting tone was associated with mild acidemia and elevated lactate (aOR 1.81, 95% CI 1.38-2.37 and aOR 1.45, 95% CI 1.17-1.80, respectively). Conclusion: Elevated intrauterine resting tone is associated with increased risk of neonatal composite morbidity. Funding: None

As far as I can tell, no abstract is necessary for HPEye submissions

We report a case of a 41-year-old male patient with no family history, presented with extensive multiple keratoacanthomas with disfiguring scars. The diagnosis of a sporadic form of Ferguson-Smith syndrome was made. Treatment with acitretin showed a marked response. Recognizing this syndrome is crucial, early treatment helps avoid scar format

The concept of symbolic power was first introduced by French sociologist Pierre Bourdieu to account for the tacit, almost unconscious modes of cultural/social domination occurring within the everyday social habits maintained over conscious subjects. Symbolic power accounts for discipline used against another to confirm that individual's placement in a social hierarchy, at times in individual relations but most basically through system institutions, in particular education. 

Serum prostate-specific antigen (PSA) plays an important role in the screening and diagnosis of prostate cancer (PCa). The recommended PSA cut-off in PCa screening is 4ng/ml. We report two cases of low PSA localized PCa which were incidentally found by computed tomography (CT) taken for another disease.

Oral mucositis (OM) is the most common local adverse event of chemotherapy treatment and leads to a debilitating condition from the patient’s perspective. The aim of this study is to report nine cases of severe OM over 10 weeks after initiating chemotherapy in pediatric patients with leukemia. All patients showed changes in normality of hematological data in most week. The most used chemotherapeutic agents were aracytin, etoposide and methotrexate. Saliva and lips were the most affected items. Well-designed observational studies are needed to better understand the risk factors for developing severe OM.

Hydroxyurea (HU) has proven benefit in sickle cell anemia (SCA), but HU is still underutilized. The Pediatric Sickle Cell Program of Northern Virginia prescribes HU uniformly regardless of symptoms to SCA patients age ≥ 9 months and prospectively tracks outcomes. HU is prescribed to maximum tolerated dosing (MTD) to target 30% Hgb F. Longitudinal data over 10 years from 2009-2019 were analyzed in 2-year intervals for hemoglobin (Hgb), fetal hemoglobin (Hgb F), hospitalizations, transfusions, and treat-and-release ED visits. Comparing the 2-year interval prior to uniform HU implementation (2009-2011) to the last 2-year interval analyzed after HU implementation (2017-2019), HU usage increased from 33% to 93%, average Hgb increased from 8.3±0.98 to 9.8±1.3 g/dL (p<0.0001), average Hgb F rose from 13±8.7% to 26±9.9% (p<0.0001), hospitalizations decreased from 0.71 (95% CI 0.54-0.91) to 0.2 (95% CI 0.13–0.28) admissions/person-year, sporadic transfusions decreased from 0.4 (95% CI 0.27–0.55) to 0.05 (95% CI 0.02–0.12) transfusions/person-year. Treat-and-release ED visit rates remained unchanged, varying between 0.49 (95% CI 0.36-0.64) and 0.64 (95% CI 0.48-0.83) visits/person-year. By the last 2-year interval, 72% of patients had Hgb ≥ 9g/dL, 42% had Hgb F ≥ 30%, 79% experienced no hospitalizations, and 94% received no transfusions. Prescription of HU uniformly for SCA patients to achieve high Hgb F resulted in significant improvements in laboratory and clinical outcomes within 2 years that continued to improve over the next 6 years. Rigorous HU implementation uniformly in a pediatric sickle cell program is feasible, effective, and sustainable.