In this paper, we develop the local convergence analysis of Newton-like fourth and fifth order iterative methods for solving a system of non-linear equations. Earlier studies as in Petkovic (Multipoint methods for solving nonlinear equations, Elsevier, Amsterdam,2013), Traub (Iterative methods for the solution of equations, AMS Chelsea Publishing, Providence, 1982) and Kalyanasundaram et al (International Journal of Applied and Computational Mathematics 3 3:2213-2230, 2017) shows that the local convergence was proved using Taylor series expansion which involved the computation of derivatives of order higher than one. For the fourth and fifth order iterative methods under consideration in this paper, it is required that the functions should be at least five and six times differentiable respectively so that the method is applicable to find the solution. This restricts the applicability of the method and also the cost in finding the solution increases as it involves the computation of higher order derivatives. The local convergence analysis derived in this paper uses Lipschitz and ω-continuity conditions which involves only first derivative (present in the method) to prove the convergence. Moreover, the present study also provides details about the radii of domain of convergence and also estimates on error bounds. Therefore, it is evident that the present study enhances the applicability of the methods under consideration. The obtained results have been verified with suitable numerical illustrations.

Terahertz (THz) imaging has an outstanding advantage of high resolution due to the high frequency and has promising potential in VideoSAR. However, limited to the THz source power and the air absorption, the THz image usually has a low SNR and is susceptible to noise in remote sensing and imaging. In order to improve the quality of THz images, a THz image enhancement method is proposed based on the noise2noise idea. The THz images are reconstructed with the AFBP algorithm. They are organized as noisy image pairs and filtered with a mask to remove the influence of moving targets. Then, the Noise2Noise network is constructed based on the CNN network and takes the noisy image pair as input and reference. In the training stage, 1000 noisy image pairs are used as the training set and 100 noisy images are used as the test set to verify the performance of the proposed method. The experimental results based on real VideoSAR data demonstrate that the proposed method is capable of suppressing noise and enhancing the THz image.

Stretchable composites comprising liquid metal (LM) inclusions and silicone elastomers (LME composites) are of great interest in the design of soft electronic and wearable devices. Soft conductors consisting of highly deformable materials and low ratio of conductive fillers offer high stretchability and good strain-tolerant conductance while not compromising the functionality of their host systems. Despite advances, actively achieving electrical conductivity for LME composites with a low ratio of conductive fillers is challenging, especially in highly deformable soft elastomers. This work introduces a new fabrication strategy that turns non-conductive LME composites with highly deformable elastomers into conductive ones using a small amount of magnetic conductive fillers (e.g., Nickel particles and LM droplets). By actively manipulating conductive fillers with an external magnetic field, the new composite can sustainably achieve electrically conductive traces at any desired locations. Experimental results show that the new LME composite can achieve high conductivity of 2.55 x 105 S m-1, high stretchability of over 450%, good strain-tolerant conductance (R/R0 ~ 1.56 at 250% strain), and especially a tensile modulus as low as 60.1 kPa at a very low loading ratio of conductive filler (9.7% by volume). The non-contacting magnetic fabrication also enables the creation of diverse configurations in 1D, 2D, and 3D forms, offering a broad range of potential applications from stretchable electronics, wearable devices, smart garments, to biomedical systems.

The movement of fine bubbles in a swirling field determines the mass transfer, heat transfer, and reaction performance of the swirl equipment. This study investigated the separation of fine bubbles strengthened by a swirling field in order to achieve higher separation efficiency of the planar cyclone through optimizing the structure of the convection field. The bubble size and gas holdup in the swirling flow field under different working conditions were explored by combining high-speed camera online measurement and computational fluid dynamics(CFD) simulation. The gas holdup and bubble size of each region in the swirl region, as well as the separation efficiency of gas by swirl eccentricity, were observed at different liquid and gas Reynolds numbers, Rel and Reg, respectively. Furthermore, the influence of different swirl eccentricities, dc, was investigated. It found that the highest separation efficiency can be achieved under all working conditions when swirl eccentricity dc= 5 mm.

Endometriosis in ectopic kidney : A rare case report and literature reviewMengLin Chen*1; YuanMeng Yu*2;XinXiang Zhao11Department of Radiology, The second Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan , China2Department of MRI , The First People ’ s Hospital of Yunnan Province , The Affiliated Hospital of Kunming University of Science and Technology , Kunming 650032, Yunnan , China*This authors contributed equally to this workCorrespondence to: Xinxiang Zhao, PhD. Department of Radiology, The second Affiliated Hospital of Kunming Medical University, Kunming, China. Email:zhaoxinxiang2918@outlook.com

Objective: To preliminarily investigate the efficacy and safety of autologous nucleated cell transplantation (ANCT) for treating Vaginal Relaxation Syndrome (VRS) patients. Methods and Samples: Ten married women with vaginal relaxation syndrome were selected from January 2019 to July 2019. All participants were treated via autologous nucleated cell transplantation once a month for three consecutive times, and followed up for 1 month after each treatment. Main Outcome Measures: The degree of vaginal relaxation, the female sexual function index (FSFI), vaginal health index score (VHIS) and subjective symptom improvement scale (PGI-C) were conducted. Results: All the 10 cases successfully completed the ANCT treatment. After ANCT treatment, there were significant improvements in the degree of vaginal relaxation. with the detailed date including (-1.06±0.78, P<0.01) in first time, (-1.30±0.91, P<0.05) in twice time and (-1.5±0.77, P<0.01) three times. Furthermore, the vaginal health index (VHIS) after first treatment (1.63±0.92, P<0.001), twice (4.33±1.51, P<0.001) and three times (3.65±1.77, P< 0.001) were significantly improved. Moreover, the scores of female sexual function index (FSFI) after first treatment (13.50±8.55), twice (18.17 ±6.46) and three times (19.65±6.7) were also substantial variation (P<0.001). According to the subjective symptom improvement score , The study indicates that ANCT can effectively improve the degree of vaginal relaxation, sexual function and vaginal health of patients with VRS, as well as vaginal compactness, wetness, air sensation and vaginal secretions. Conclusion: The novel ANCT method heighten the quality of sexual life may be a better choice for non-surgical treatment of private plastic surgery for VRS patients.

The 3D TEE is a powerful imaging tool that now is the standard of care in the evaluation of heart valve disease, in guiding the percutaneous catheter-based procedures and in learning functional anatomy. 3DTEE provides incremental information over 2DTEE in patients with aortic aneurysm and dissection type A 1. In literature there are few data about the contribute of the third dimension in the transesophageal echocardiography (TEE) in type B aortic dissections and there are described during thoracic endovascular aortic repair 2;3.

We present a rare case of spontaneous osteodiscitis of the cervical spine complicated by epidural abscess/phlegmon, burst fracture, and spinal cord injury due to methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in a patient with a history of intravenous drug use who presented with neck pain.

The coexistence of central venous occlusion (CVO) and arteriovenous fistulas (AVF) is rare among non-dialysis patients, and its diagnosis and treatment can be challenging. Herein, we describe a case of left brachiocephalic vein occlusion (BVO) with spontaneous AVF presenting with severe edema of the left upper extremity and face.

Pellentesque tincidunt lobortis orci non venenatis. Cras in justo luctus, pulvinar augue id, suscipit diam. Morbi aliquet fringilla nibh, vel pellentesque dui venenatis eget. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec ultricies ultrices magna gravida porta. Maecenas accumsan diam dui, auctor ornare ex pellentesque id. Integer tempus massa id augue finibus convallis. Nulla vestibulum, nisl id tempor pulvinar, felis dui pellentesque lacus, quis bibendum metus enim sed ex.

The hydrodynamic connection and vertical movement of water between aquifers in the south-east of the East European Platform to a depth of up to six kilometers through halogen deposits with a capacity of up to a kilometer have been investigated. Pressure points in aquifers in depth in an undisturbed state are located on the line of normal hydrostatic pressure. Deviations from it indicate a man-made impact on groundwater. The actual pressure in aquifers is determined by the height of the water column above the measuring point and its weighted average volumetric weight. The static levels of groundwater in its natural state are determined by the level of the river draining them, exceeding it by several meters, and have close reduced static levels. A method has been developed for determining the filtration coefficient of rocks on cores without preliminary mechanical processing. A method for determining the direction and value of water flows through poorly permeable cover rocks in gas and oil fields is proposed. The directions and values of groundwater flows through the cover rocks of deep-lying horizons at oil and gas fields in the Buzuluk depression of the platform are established. In natural conditions,

Photodynamic therapy (PDT) has received increasing attention in cancer treatment because of its advantages such as minimally invasive and selective destruction. With the development of PDT, impressive progress has been made in the research of preparing photosensitizers, especially porphyrin photosensitizers. However, the limited tissue penetration and light energy capture efficiency of porphyrin photosensitizers have been the two major obstacles for conventional photosensitizers. Therefore, it is necessary to enhance the tissue penetration and improve the light energy capture efficiency of porphyrin photosensitizers through structural modifications. In addition, indirect excitation of porphyrin photosensitizers using fluorescent donors (fluorescence resonance energy transfer) has been successfully used to address these issues. In this manuscript, we focus on how to enhance the photoenergy capture efficiency of porphyrin photosensitizers, aiming to improve the efficiency of singlet oxygen (1O2) production in tumor tissues and enhance the photodynamic therapy effect of photosensitizers.

A population pharmacokinetic (PPK) model for creatinine was successfully developed using creatinine concentration data from 6 healthy male volunteers with and without ingestion of 225 g boiled beef as an exogenous creatinine source. A model with first-order absorption, zero-order creatinine generation, and first-order elimination was used to describe the pharmacokinetic (PK) data. Creatinine parameters, estimated from the final model were: apparent absorption rate constant (Ka, 1.71 1/h), lag time (0.343 h), renal clearance (equal to systemic clearance) (CL, 7.57 L/h), apparent volume of distribution (Vd, 52.8 L), and creatinine generation rate (CGR, 67.8 mg/h). The CL and CGR estimates were in agreement with the reported values, whereas the Vd estimates were slightly higher than the reported values. The model is a useful starting point for further experimental approaches to improve the understanding of creatinine kinetics, which may involve creatinine “dosing” accompanied by independent methods to assess the glomerular filtration rate.

A document by Üzeyir Cimen. Click on the document to view its contents.

Aim: To establish a population pharmacokinetic modeling of rocuronium in geriatric patients undergoing surgery. Methods: Blood samples were collected after administration of rocuronium and the relevant datas were collected. The plasma concentrations of rocuronium were determined by UPLC-MS/MS method. The collection time of the sample is set as the independent variable and the plasma concentration of rocuronium as the dependent variable; all the significant effects were included in covariates. The covariates affecting the pharmacokinetic parameters of rocuronium in geriatric were quantitatively investigated through the nonlinear mixed effect model by Phoenix WinNonlin 8.3 software. Results: The final model is consistent with the three-compartment model, and the residual model is proportional as residual model. The final model formula is as follows: V=tvV*exp(nV)，V2=tvV2，V3=tvV3；Cl=tvCl*ALB∧dCldALB*Urea∧dCldUrea*exp(nCl)，Cl2=tvCl2，Cl3=tvCl3.式中tvV=1.313L，tvV2=0.762L，tvV3=1.043L，tvCl=0.041L/h，tvCl2=3.238L/h，tvCl3=0.618L/h，dCldALB=1.015，dCldUrea=0.360.The final model shown that ALB and Urea are covariates that could affect the clearance rate of pharmacokinetic central Compartment. The validation and prediction results had shown a good stability. Conclusion: The results suggest that ALB and Urea might affect rocuronium clearance rate. Pharmacokinetic parameters can be personalized according to the actual situation of patients, which can provide reference for the adjustment of rocuronium medication and pharmaceutical care plan in clinical treatment of geriatric surgery, to ensure the safety and postoperative recovery of geriatric during operation.

Body size plays an important role in predator-prey interactions, but its evolution is often limited due to all sorts of constraints. The arms race between bats and moths provides great opportunities to study body size evolution and associated traits across a wide range of species. Nocturnally-active moths are in particular limited in evolving larger bodies, as any increase in echo-acoustic reflective surface will put them more at risk of a bat's sonar system. Here we assessed whether moths can escape bat detection in a size-dependent way by increasing their acoustic camouflage through ultrasonic absorptive body scales. We used an automated setup to 3D scan a total of 110 moth specimen, from eight different families of Lepidoptera using a biomimetic bat head. We carried out three different ensonification experiments with intact, partially shaved and fully shaved moth specimen to relate the level of acoustic camouflage to various body size measurements. Comparing shaved versus intact specimen we found a clear reduction in target strength, although the effect strongly depends on frequency range as well as body size. The stealth coating provided by sound absorptive body scales can reduce prey detectability up to 365 cubic metres and is in particular beneficial to larger species. The level of acoustic camouflage did not covary with other anti-predator traits, such as ultrasonic ears and appears to be an all-round anti-predator strategy. Acoustic camouflage through stealth coating thus allows moths to escape from the allometric relationship between size and detection risk, thereby enabling species to evolve larger bodies.

Characterization of thermal properties of different ages highland bamboo fiber attributes extracted chemically and mechanically is the focus of this work. The sample ware subjected to different analyses for each corresponding age (1year, 2years, and 3 years) and NaOH Concentration (untreated, 1%, 2%, and 3%) levels using thermogravimetric analysis (TGA), differential scanning calorimetric (DSC), differential thermogravimetric analysis (DTG), and differential thermal analysis (DTA) for thermal properties characterization. Scanning electron microscopy (SEM) for morphological studies and Fourier transform infrared spectroscopy (FTIR) for the identification of functional groups of the fibers. The surface appearance of the cell wall and microfibril aggregates were changed by alkali treatment. From the SEM results, 3% NaOH treated fiber resulted in more wrinkles on the surface of bamboo fibers when compared with the 1% and 2%NaOH Bamboo fiber. Using thermal analyse measurments, the study investigated weight loss increased as alkali concentration increased but the scenario functioned for proper concentration. The first Degradation stage is responsible for the biggest weight loss since it includes the disintegration of all of the fiber’s primary components (cellulose, hemicellulose, and lignin).

Lactic acid bacteria (LAB) species are gaining recognition in fermentation-related biotechnologies due to their rapid growth and beneficial organic acid production. This study integrated genome and transcriptome sequencing to understand the molecular mechanisms of organic acid biosynthesis in Lactobacillus plantarum YC1-1-4B and Lactobacillus buchneri PC-C1. We identified several novel culture time-induced pathways associated with organic acid biosynthesis, including metabolic equilibriums and the expression of growth-related proteins. Lactic and acetic acid concentrations dominated other acids, with YC1-1-4B containing the highest concentrations (29.18 ± 2.17 mg/L) of beneficial organic acids at 12h. The reconstruction of organic acid metabolic pathways uncovered novel genes, including ldh and ackA, upregulated in YC1-1-4B at 12h and unregulated in PC-C1 at 6h and 12h. Also, the massive induction of differential gene expressions at 12h, including sucC and sucD gene overlap, suggests translational coupling, which could potentially benefit the combination of the two LAB species during industrial fermentation.

We report an extremely rare case of an ingrown nail with a subungual myiasis on the same toe in a female patient with no previous history of travel, trauma, contact with animals, immunosuppressive treatment or psychiatric disorders.

Purpose: Fractures of the mandibular condylar process are the most common fractures in the maxillofacial region. Surgical treatment of condylar region fractures with miniplates and miniscrews has become quite popular because it is a stable method and allows for immediate function. The present study examined sheep hemimandibular subcondylar fracture models to evaluate the biomechanical properties of two miniplate/screw system types, which are used to surgical fixation of subcondylar fractures. Experimental: The experimental standardized subcondylar fracture lines were examined in ten sheep hemimandibula models. Each segment was fixated with one of two fixation types: double straight miniplates with eight miniscrews or single, one rhombic-shaped miniplate with five miniscrews. All models were mounted in a servohydraulic testing unit, and continuous linear force was loaded. The maximum force and displacement values were compared and analyzed statistically. Results: The rhombic miniplate group had statistically significantly lower values than the double straight miniplate group for maximum force, work at maximum load, and hardness. There was no statistically significant difference between the two groups in terms of displacement at maximum load. Conclusion: Considering the advantages of rhombic shaped miniplates, they are suggested as a clinically reliable treatment alternative for the surgical fixation of subcondylar fractures.

Aspiration thrombectomy is often performed in patients with acute myocardial infarction with high thrombus burden. Current guidelines, however, recommend against it because of stroke risk. We report a case of embolic stroke complicating coronary thrombus aspiration by an extremely rare mechanism.

Supraventricular tachycardia (SVT) poses a clinical challenge during pregnancy, particularly if refractory to antiarrhythmic medications. Performing catheter ablation during pregnancy necessitates careful risk benefit analysis for both the mother and fetus, especially with left-sided ablations that may require post-procedural systemic anticoagulation. We describe a pregnant woman with refractory atrial tachycardia (AT) which failed a multi-antiarrhythmic drug regimen and ultimately developed abruptio placentae, requiring a carefully staged ablation approach for definitive treatment.

Placement of coronary sinus (CS) leads is predominantly accomplished via the left cephalic-axillary-subclavian (CAS) venous system. However, vein stenosis or occlusion from long-term chronic hemodialysis in patients with end-stage renal failure can pose a challenge. Cannulation of the CS via the left Internal jugular vein is technically difficult but often feasible. We report a case in which a patient with ESRD had extensive left venous system occlusion from prior in dwelling hemodialysis catheters, and an AV fistula contralaterally, who underwent biventricular- implantable cardioverter defibrillator (BiV-ICD) placement with lead insertion through the left internal jugular vein (IJV).

In order to quantify the site-dependent correlation strengths in terms of the quasi-particle weights and the occupation numbers of 5f electrons in alpha phase plutonium metal with eight crystallographically nonequivalent atomic sites Pun (n=1~8), we perform a first principles calculation by using a many-body method merging density functional theory (DFT) with dynamical mean-field theory (DMFT) plus the relativistic and correlation effects. The quasi-particle weight, the electronic spectrum function, the hybridization function, as well as the occupation number of Pu 5f electrons all suggest that Pu1 and Pu8 atoms have the most itinerant and the most localized 5f electrons, respectively, while the other atoms Pun (n=2~7) exhibit an intermediate correlation strength. The quasi-particle weights demonstrate that only the jj or intermediate coupling scheme is more appropriate for Pu 5f electrons in comparison with the Russel-Saunders (LS) scheme. The electronic spectrum function and the occupation analysis establish that Pu 5f electrons simultaneously have dual itinerant and localized regimes with average 5f occupation numbers of nf between 4.8994 and 4.9628, which are mainly composed of 5f4, 5f5 and 5f6 configurations, irrespective of different atomic sites. Finally, we also estimate the so-called quasi-particle band structure to directly compare with an experimental angle-resolved photoemission spectrum (ARPES).