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Modeling-based performance assessment of an indigenous macro-catchment water harvesti...
Giulio Castelli
Niccolò Renzi

Giulio Castelli

and 7 more

March 21, 2023
Water resources management is fundamental for rural communities in drylands. Water Harvesting Technologies (WHT) intercept and store the excess rainfall (surface runoff) in soils for increased plant available water and agricultural productivity. The so-called ‘Marab’ WHT was initially developed by Middle Eastern agro-pastoralists that reside or commute in semi-arid and arid rangelands. The Marab WHT is a macro-catchment measure consisting of earth dams and stone spillways along the contours of a lowland depression or floodplain. Dependent on the local context (i.e. climate, soil, management, etc.) the established Marabs show highly-variable effectiveness. This study aims at filling the knowledge gap on the WHT’s performance in changing environments by simulating its hydro-agrological effects for different soils and climatic conditions using the AquaCrop model. A case study performed for a Jordanian Marab over three seasons (2019-2022) confirms its huge improvement potential for barley production. Through Marab-farming, barley production reached 8.37 t ha -1 on average, versus highly variable 0.34 t ha -1 without the WHT. The simulation-based assessment of soil textures identified that silty soils have the largest potential for producing up to 9.25 t ha -1 barley, compared to 6.60 t ha -1 produced in clay soils. Assessing different climate scenarios, a slight increase in daily average temperatures (+ 0.5°C) led to a considerable production decline of 4-8%, while a significant reduction of precipitation (-20%) decreased biomass production by a similar rate (4-10%). This underlines the robustness of the ‘Marab’ WHT to rainfall amount variation. However, simulations also highlight the sensitivity of timing and frequency of flood events: removing the last and the first flood event reduced biomass production by approximately 50% and 80% respectively, while the barley fails to develop if both events were suppressed.
Toward Maximum Energy Density Enabled by Anode-Free Lithium Metal Batteries; Recent P...
Cheol-Young Park
Jinuk Kim

Cheol-Young Park

and 3 more

March 21, 2023
Owing to the emergence of energy storage and electric vehicles, the desire for safe high-energy-density energy storage devices has increased research interest in anode-free lithium metal batteries (AFLMBs). Unlike general LMBs, in which excess Li exists to compensate for the irreversible loss of Li, only the current collector is employed as an anode and paired with a lithiated cathode in the fabrication of AFLMBs. Owing to their unique cell configuration, AFLMBs have attractive characteristics, including the highest energy density, safety, and cost-effectiveness. However, developing AFLMBs with extended cyclability remains an issue for practical applications because the high reactivity of Li with limited inventory causes severely low Coulombic efficiency, poor cyclability, and dendrite growth. To address these issues, tremendous effort has been devoted to stabilize Li-metal anodes for AFLMBs. In this review, we highlight the importance and challenges of AFLMBs. Then, we thoroughly review diverse strategies, such as modifying current collectors, the formation of robust interfaces by engineering advanced electrolytes, and operation protocols. Finally, a future perspective on the strategy is provided to insight into the basis of future research. We hope that this review provides a comprehensive understanding by reviewing previous research and arousing more interest in this field.
Genomic Epidemiology Analysis of Circulating Virus Of Nepal.
Bimalesh Jha
krishna Manandhar

Bimalesh Jha

and 1 more

March 21, 2023
Introduction Influenza viruses, due to rapid evolution, lead to great variability. There are 18 highly variable hemagglutinins (H1 to H18) and 11 distinct NAs (N1 to N11) for type A.Influenza type B has no subtypes due to fixed on small antigenic variabilities.Due to rapid evolution and diversification, it is essential to understand genomic epidemiology to detect emerging strains and track their transmission. Methods Samples of the strain were cultivated in the MDCK cell lines for the preparation of neat virus. viral genome after extraction from the neat virus was sent to the National Institute of Infectious Disease, Japan for whole genome sequencing in 2016. The sequences were submitted to GISAID. The H1N1 virus genomes(n=18), from this study, were investigated against the reference genome A/California/07/2009 (GenBank: CY121680). Similarly, the Influenza type B virus genomes(n=27) were investigated against reference genome B/Brisbane/60/2008 (GenBank: KX058884) and B/Wisconsin/01/2010 (GenBank: JN993010). The mutational analyses were performed using Nextclade. The mutations present in the sequences were,subsequently, investigated. Finally, the phylogenetic analysis was done using the Nextclade and CLUSTAL Omega. Out of the 18 HA genome segments, of H1N1, all (n=12) except 6 isolates were of clade 6B, while the rest were of clade 6B.1.For Influenza Type B, out of the 27 HA genome segments, all of the genomes were of clade V1A when compared to B/Brisbane/60/2008. Similarly, when compared to reference genome B/Wisconsin/01/2010 (GenBank: JN993010), all (n=22) except 5 isolates were of clade Y3, while the rest were of clade Y2
Temporal Configuration -- Unlocking Hidden Streamflow Properties
Richard Koehler

Richard Koehler

March 21, 2023
Analytical tools are needed to identify and quantify artificial short- and long-term discharge fluctuations, which can disrupt the natural processes of a river. To measure the properties of discharge magnitude, frequency, duration, timing and flow change, such tools typically use a subset of metrics selected from over 170 descriptive statistical indices. Many metrics are based on multi-day mean or median discharges with associated variance or use a single value to describe the entire dataset. However, these source indices do not quantify the temporal configuration of streamflow, an additional hydrologic property that is often overlooked. To address this situation, a non-index approach to quantify all streamflow properties has now been developed using analysis methods based on the lag (1) temporal autocorrelation signature of the streamflow. The discharge (Q), discharge change (dQ/dt), and rate of discharge change (d 2Q/dt 2), along with sequential summations, are presented in novel infographics. A dam release river impact case study for the Colorado River at Lees Ferry, Arizona, is included to demonstrate this innovative way of analyzing streamflow datasets. The result is a set of new tools which yield detailed information about the hydrologic regime, are highly customizable, and can either be used as a stand-alone analysis or be integrated into other existing data analysis techniques. The end result is a better understanding of the hydrologic regime, more focused research, and more effective management planning.
Changes in the Natural Water Retention of mountainous landscapes since the 1820s in t...
Stecher Gabriel
Severin Hohensinner

Stecher Gabriel

and 2 more

March 21, 2023
Interactions of humans with the environment are strongly related to land use and land cover changes and the available ecosystem services. In last decades, these changes have led to a degradation of ecosystem services, including water regulation and flood control. In Alpine areas of Austria, land cover changes have increased flood risk since the mid of the 19 th century. In this paper, we assess the influence of these long-term land use changes on the landscape’s ability to retain water using the qualitative Water Retention Index (WRI). The changes are thereby evaluated using the historical (1826-1859) and present (2016) land cover situation, which is to our knowledge the first high-resolution and regional application of the WRI. The results show that the water retention potential mimics the mountainous characteristic and features. Except for areas strongly dominated by settlement areas, the highest retention potentials are found in valley floors and the lowest values are depicted along the Alpine main complex. In low-lying areas, the retention decreased by over 10 %. It was found that this decrease can be mostly attributed to settlement expansion. Above 1250 m land use transformations led to slightly increasing water retention values owing to the transformation of wasteland or glaciers to stagnant waters and to the expansion of forest and grassland in high elevations. This examination allows for a holistic and spatially distributed LULCC impact assessment on the landscape’s water regulation capacities and offers valuable high-resolution information for future land use planning and sustainable land development.
Complete mitochondrial genomes of two moths in the tribe Trichaeini (Lepidoptera: Cra...
Ci Tang
Xicui Du

Ci Tang

and 1 more

March 21, 2023
The complete mitochondrial genomes of two Prophantis species in the tribe Trichaeini (Lepidoptera: Crambidae) were sequenced using high-throughput sequencing technology. They were assembled and annotated: the complete mitogenomes of P. octoguttalis and P. adusta were 15,197 bp and 15,714 bp, respectively, and contain 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and an A + T-rich region. Their arrangement was consistent with the first sequenced mitogenome of Lepidoptera, from Bombyx mori (Bombycidae). The nucleotide composition was obviously AT-biased, and all protein-coding genes, except for the cox1 gene (CGA), used ATN as the start codon. Except for trnS1, which lacked the DHU arm, all tRNA genes could fold into the clover-leaf structure. Phylogenetic trees of Crambidae were reconstructed based on mitogenomic data using Maximum likelihood (ML) and Bayesian inference (BI) analysis methods. Results showed that Trichaeini in this study robustly constitute a monophyletic group in Spilomelinae, with the relationships (Trichaeini + Nomophilini) + ((Spilomelini + (Hymeniini + Agroterini)) + Margaroniini). However, the affinities of the six subfamilies Acentropinae, Crambinae, Glaphyriinae, Odontiinae, Schoenobiinae and Scopariinae within the “non-PS Clade” in Crambidae remained doubtful with unstable topologies or low supports.
A novel mosquito species identification method based on PCR and capillary electrophor...
Estelle Chabanol
Ottavia Romoli

Estelle Chabanol

and 6 more

March 21, 2023
In the Anopheles genus, various mosquito species are able to transmit Plasmodium parasites responsible for malaria, while others are non-vectors. In an effort to better understand the biology of Anopheles species and to quantify transmission risk in an area, the identification of mosquito species collected on the field is an essential but problematic task. Morphological identification requires expertise, well-preserved specimens and high-quality equipment, and it does not allow any subsequent verification when samples are later used in a destructive treatment. Moreover, it involves physical manipulations that are not compatible with experiments requiring fast sampling and processing of specimens, hence species identification is often based on DNA sequencing of reference genes or region such as the Internal Transcribed Spacer 2 (ITS2) region of nuclear ribosomal DNA. Sequencing ITS2 for numerous samples is costly, but the design of species-specific PCR primers is not always possible when local species diversity is high. Here, we introduce a molecular technique of species identification based on precise determination of ITS2 length combined with a simple visual observation, the color of mosquito hindleg tip. DNA extracted from field-collected Anopheles mosquitoes was amplified with universal Anopheles ITS2 primers and analyzed with a capillary electrophoresis device, which precisely determines the size of the fragments. We defined windows of amplicon sizes combined with fifth hind tarsus color, which allow to discriminate the major Anopheles species found in our collections. We validated our parameters via Sanger sequencing of the ITS2 amplicons. This method can be particularly useful in situations with a moderate species diversity, i.e. when the number of local species is too high to define species-specific primers but low enough to avoid individual ITS2 sequencing. This tool will be of interest to evaluate local malaria transmission risk and this approach may further be implemented for other mosquito genera.
Mittag-Leffler-Gould-Hopper polynomials: Symbolic Approach
Umme Zainab
Nusrat Raza

Umme Zainab

and 1 more

March 21, 2023
The paper describes the method of symbolic evaluation that serves as a useful tool to extend the studies of certain special functions including their properties and capabilities. In the paper, we exploit certain symbolic operators to introduce a new family of special polynomials, which is called the Mittag-Leffler-Gould-Hopper polynomials. We obtain the generating function, series definition and symbolic operational rule for these polynomials. This approach give a wide platform to explore the study of classical and hybrid special polynomials. We establish summation formulae and certain identities for these polynomials. Further, we derive the multiplicative and derivative operators to study the quasi-monomiality property of these polynomials. Some concluding remarks are also given.
Increasing trends in a low 5-minute Apgar score among (near) term singletons: a Dutch...
C.E. Tacke
Wes Onland

C.E. Tacke

and 7 more

March 21, 2023
Objective: To investigate trends in low 5-minute Apgar scores in (near) term singletons. Design: Nationwide cohort study. Setting: The Netherlands. Population: A cohort of 1,583,188 singletons liveborn between 35 +0 and 42 +6 weeks of gestation in the period 2010-2019 from the Dutch Perinatal Registry. Methods: We studied trends using Cochrane-Armitage trend tests. Risk factors were studied by logistic regression analysis and Population Attributable Risk (PAR) calculation. Main outcome measures: Low 5-minute Apgar score (<7 and <4) as primary outcome. Results: The proportion of infants with low 5-minute Apgar score <7 and <4 increased significantly between 2010 and 2019 (1.04-1.42% (p<0.001), 0.17-0.19% (p=0.009), respectively). While neonatal mortality remained unchanged, NICU admissions and low umbilical artery pH’s increased significantly. Many perinatal characteristics showed a significant association with low Apgar scores. The highest risks were found for nulliparity, epidural analgesia, emergency caesarean section, instrumental vaginal delivery, prolonged second stage of labour, male sex and delivery in secondary care. The obstetric interventions induction of labour, epidural analgesia and planned caesarean section showed an increasing trend. Instrumental vaginal delivery and emergency caesarean section were performed less frequently over time, however within these obstetric intervention subgroups the highest increase in low Apgar scores was observed. Conclusions In the Netherlands, the risk of a low 5-minute Apgar score increased significantly over the last decade, with the highest increase being observed in the obstetric intervention subgroups of instrumental vaginal delivery and emergency caesarean section. Neonatal mortality remained stable over the study period.
The Possible Role of Artificial Intelligence in Deciding Postnatal Steroid Management...
Shabih Manzar
Archana Bottu

Shabih Manzar

and 1 more

March 21, 2023
The Possible Role of Artificial Intelligence in Deciding Postnatal Steroid Management in
Dyspnoea, haemoptysis and fever progressing to acute respiratory failure. A didactic...
Karolina Dolezalova
Fajt M.

Karolina Dolezalova

and 3 more

March 21, 2023
A dynamic case report in which the authors present a multidisciplinary collaboration in a dyspnoic adolescent girl who coughs up blood, has a high temperature and rapidly progresses to respiratory failure. Laboratory findings, imaging results, and their interpretation are shown. Current recommended management is discussed.
Periodic breathing beyond the neonatal period: a case series
O. CHEYROU-LAGRÈZE
E. Hullo

O. CHEYROU-LAGRÈZE

and 6 more

March 21, 2023
Introduction: Periodic breathing (PB) is considered physiological in the neonatal period but must disappear in the first months of life. Few data regarding PB after the neonatal period are available. The objective of this study was to describe the clinical and polysomnographic characteristics of infants presenting with PB after the age of 1 month. Methods: This French multicenter retrospective case series included infants born at term between 2012 and 2021, without underlying disease, and who presented during a polysomnography (PSG) recording more than 1% of PB after 1 month of life. Results: Overall, 10 infants were included, they underwent a PSG for brief resolved unexplained event, desaturation, pauses in breathing, cyanosis, and/or signs of respiratory distress. The percentage of total sleep time spent with PB was 18.1% before 3 months (n=7), 4.7% between 3 and 6 months (n=10), 7.1% between 7 and 12 months (n=2), and 0% after 12 months (n=2). During the first PSG, ≥ 3% desaturations were observed in 77% to 100% of the PB episodes. At the first PSG, 9/10 infants had an obstructive apnea hypopnea index > 10/h and 5/10 had a central apnea index > 5/h. Gastro-esophageal reflux (GER) was suspected in 8/10 infants. All infants showed improvement in initial symptoms during the first year of life. Conclusion: Although PB is rare after 1 month of age, the present study shows that when present, PB is most frequently associated with obstructive and/or central apnea syndrome in term infants without comorbidities other than GER.
Endobronchial mucosal nodules and actinomycosis in a child with activated phosphatidy...
Kwan Fung LAM
Shun CHAN

Kwan Fung LAM

and 5 more

March 21, 2023
A 5-year-old girl had poor growth and unresolving pneumonia. There was persistent collapse-consolidation of the right middle lobe. CT thorax revealed bilateral bronchial wall thickening and dilatation. Bronchoscopy showed numerous endobronchial mucosal nodules, consisting of dense lymphoid infiltrates. Bacterial culture of the nodule biopsy suggested endobronchial actinomycosis. She had T-cell lymphopenia. Genetic test confirmed the diagnosis of activated phosphatidylinositol 3-kinase delta syndrome (APDS), an immunodeficiency condition.
Seroprevalence and Clinical Characteristics of SARS-CoV-2 Infection in Children with...
Georgene Hergenroeder
Anna Faino

Georgene Hergenroeder

and 6 more

March 21, 2023
Background: People with cystic fibrosis (PwCF) have chronic lung disease and may be at increased risk of COVID-19-related morbidity and mortality. This study aimed to determine seroprevalence and clinical characteristics of SARS-CoV-2 infection in children with CF, and to assess antibody responses following SARS-CoV-2 infection or vaccination. Methods: Children and adolescents with CF followed at Seattle Children’s Hospital were enrolled between July 20, 2020 and February 28, 2021. SARS-CoV-2 serostatus was determined on enrollment, at 6 and 11 months (+/-2 months) for nucleocapsid and spike IgG. Participants completed intake and weekly surveys inquiring about SARS-CoV-2 exposures, viral/respiratory illnesses, and symptoms. Results: Of 125 PwCF enrolled, 14 (11%) had positive SARS-CoV-2 antibodies consistent with recent or past infection. Seropositive participants were more likely to identify as Hispanic (29% vs 8%, p=0.04) and have pulmonary exacerbations requiring oral antibiotics in the year prior (71% vs 41%, p = 0.04). Five seropositive individuals (35.7%) were asymptomatic, while six (42.9%) reported mild symptoms, primarily cough and nasal congestion. Anti-spike protein IgG levels were approximately 10-fold higher in participants following vaccination compared with participants who had natural infection alone (p < 0.0001) and resembled levels previously reported in the general population. Conclusions: A majority of PwCF have mild or no symptoms of SARS-CoV-2 making it difficult to distinguish from baseline respiratory symptoms. Hispanic PwCF may be disproportionately impacted, consistent with racial and ethnic COVID-19 disparities among the general US population. Vaccination in PwCF generated antibody responses similar to those previously reported in the general population.
BlockCompass: A benchmarking platform for blockchain performance
Mohammadreza Rasolroveicy
Wejdene Haouari

Mohammadreza Rasolroveicy

and 2 more

March 21, 2023
A document by Mohammadreza Rasolroveicy . Click on the document to view its contents.
The better the relationship the more coordinated cooperation in dating couples? An Ev...
Fei Wang
Xiao Gong

Fei Wang

and 5 more

March 20, 2023
Existing research has found that individuals with higher relationship quality in intimate relationships tend to exhibit higher levels of tacit understanding and better interpersonal coordination in social interactions. However, the cognitive neural mechanisms between intimate relationship quality and interpersonal coordination are unclear. We thus argued that interpersonal neural synchronization during interpersonal interactions is an important mediator of intimacy quality and interpersonal coordination. To test this hypothesis, interpersonal neural synchrony and interpersonal coordination were measured in heterosexual dating couples during the completion of a jigsaw puzzle interaction task using an EEG-based hyperscanning technique. A total of 33 couples’ data were included in the analysis. The results showed that β-band synchronization in the left sensorimotor cortex of both members of a romantic couple fully mediated the relationship between intimacy quality and interpersonal coordination during the jigsaw puzzle task. In addition, we found that intimacy quality significantly predicted interpersonal neural synchrony in a jigsaw puzzle task with interaction but not in a jigsaw puzzle task without interaction. These findings support the idea that intimacy is a result of interindividual interactions and that interpersonal neural synchronization during interactions plays an important role in relationship quality and interpersonal coordination.
The HPA and SAM axis mediate the impairment of creativity under stress
Xiaoyu Guo
Yifan Wang

Xiaoyu Guo

and 5 more

March 20, 2023
With the ever-changing social environment, individual creativity is facing a severe challenge induced by stress. However, little is known about the physiological mechanisms by which acute stress affects creative cognitive processing. The current study explored the effects of neuroendocrine response on creativity under stress and its underlying cognitive flexibility mechanisms. The Enzyme-Linked Immuno Sorbent Assay was used to assess salivary cortisol, which acted as a marker of stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. Eye blink rate (EBR) and pupil diameter were measured as respective indicators of dopamine and noradrenaline released by activation of the sympathetic-adrenal medullary (SAM) axis. The Wisconsin Card Task (WCST) measured cognitive flexibility, while the Alternative Uses Task (AUT) and the Remote Association Task (RAT) measured separately divergent and convergent thinking in creativity. Results showed higher cortisol increments following acute stress induction in the stress group compared to the control group. Ocular results showed that the stress manipulation significantly increased EBR and pupil diameter compared to controls, reflecting increased SAM activity. Further analysis revealed that stress-released cortisol impaired the originality component of the AUT by increasing perspective errors of the WCST. Serial mediation analyses showed that both EBR and pupil diameter were also associated with increased perspective errors leading to poor originality on the AUT. These findings confirm that physiological arousal under stress can impair divergent thinking through the regulation of different neuroendocrine pathways, in which the deterioration of flexible switching plays an important mediating role.
Efficiency of county-level public and private hospitals in a western province, China...
Ying Zhu
Wenhui Mao

Ying Zhu

and 3 more

March 20, 2023
Background Rising costs of medical service and the need to better utilize limited resources makes the pursuit of hospital efficiency a key objective for healthcare systems. There is inconsistent evidence regarding the comparison of hospital efficiency. In China, limited research has been conducted in comparing the efficiency of Chinese public and private hospitals at the county-level, especially in western China where national GDP falls in the lowest quartile. Method We selected county-level hospitals from one western province by convenience sampling and conducted questionnaire survey in 2018. We first measured efficiency for the hospitals by bootstrap data envelopment analysis (DEA) with the following input variables: hospital bed, expensive equipment, medical staff and operating expenditure, and output variables revenue from outpatient and inpatient services; the efficiency scores were compared statistically between public and private hospitals by normality and non-parametric tests. Then we conducted bootstrap truncated regression on the estimated efficiency scores against environmental and institutional factors. Results Sixty-four county hospitals from 30 counties across the province were included in the study: 52 public hospitals, and 12 private hospitals. Relative efficiency was estimated to be 0.83 for public hospitals, and 0.96 for private hospitals, with statistically significant difference (p=0.001). Approximately 25.0% and 83.3% of public and private hospitals, respectively, were efficient. The truncated regression showed that being a private hospital (p<0.001), higher physician-nurse ratio (p=0.007), and higher revenue from outpatient services (p=0.041) were able to increase the efficiency by 0.158 (0.116, 0.199), 0.305 (0.190, 0.420), and 0.253 (0.129, 0.378), respectively. Conclusion The overall efficiency of the county level hospitals in a western province of China in 2018 was low. Private county hospitals were significantly more efficient than their public counterparts. Outpatient service revenue and physician nurse ratio were determinants of county hospital efficiency and may serve as future policy intervention targets.
Intra-operative neurophysiological monitoring in patients with pre-operative neurolog...
Yinkun Li
Junyin Qiu

Yinkun Li

and 7 more

March 20, 2023
Objective. To analyze the performance of intra-operative neurophysiological monitoring (IONM) including somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) in patients with pre-operative neurological deficit and to identify the high-risk factors for failed IONM. Methods. Patients with pre-operative neurological deficit undergoing spinal surgery between October 2010 and August 2019 were retrospectively reviewed. The presence or absence of SEP and MEP of target muscles were separately recorded and the high-risk factors for failed IONM results were investigated. Results. A total of 136 patients (86 males, 50 females) with an average age of 43.0±17.7 years were included. The muscle strength of recorded muscles in 272 lower extremities included grade 1 in 25 muscles, grade 2 in 15, grade 3 in 41, grade 4 in 134 and grade 5 in 57. The SEP records were available in 177 (65.1%) lower extremities while MEP records were available in 199 (73.2%) lower extremities. Significantly higher success rates of SEP and MEP were obtained in lower extremities with muscle strength of grade 4-5 than those of grade 1-3 (P<0.001). Patients with spinal trauma and cervical spinal stenosis were associated with more prevalent failed IONM results. Conclusions. The overall success rates of SEP and MEP were 65.1% and 73.2%, respectively. The high-risk indicators for failed IONM results included muscle strength lower than grade 4, spinal trauma and cervical spinal stenosis.
Bioinformatics-guided Disproportionality Analysis of Sevoflurane-Induced Nephrogenic...
Akhil T Jacob
Ankitha  Hari Kumar

Akhil T Jacob

and 4 more

March 20, 2023
C. Abstract AIM: Sevoflurane is an ether-based inhalational anesthetic that induces and maintains general anesthesia. Our study aimed to detect sevoflurane-induced nephrogenic diabetes insipidus using Data Mining Algorithms (DMAs) and molecular docking. The FAERS database was analyzed using OpenVigil 2.1 for disproportionality analysis. Methods: We analyzed FAERS data from 2004 to 2022 to determine the incidence of nephrogenic diabetes insipidus associated with sevoflurane. Reporting Odds Ratios (RORs) and Proportional Odds Ratios (PRRs) with 95% confidence intervals were calculated. We also used molecular docking with AutoDock Vina to examine sevoflurane’s binding affinity to relevant receptors. Results: A total of 554 nephrogenic diabetes insipidus cases were reported in FAERS, of which 2.5% (14 cases) were associated with sevoflurane. Positive signals were observed for sevoflurane with reporting odds ratios (ROR) of 76.012 (95% CI: 44.67-129.35) and proportional odds ratios (PRR) of 75.72 (Chi-sq: 934.688). Of the 14 cases, 50% required hospitalization, 14% resulted in death, and the remaining cases were categorized as other outcomes. Molecular docking analysis showed that sevoflurane exhibited high binding affinity towards AQP2 (4NEF) and AVRP2 (6U1N) with docking scores of -4.9 and -5.3, respectively. Conclusion: Sevoflurane use is significantly associated with the incidence of nephrogenic diabetes insipidus. Healthcare professionals should be cautious when using this medication and report any adverse events to regulatory agencies. Further research is needed to validate these findings and identify risk factors while performing statistical adjustments to prevent false-positives. Clinical monitoring is crucial to validate potential adverse effects of Sevoflurane.
Scale-dependent niche segregation along dimensions of rocks, vegetation and elevation...
Harsha K Kumar
Dhanesh Ponnu

Harsha Kumar

and 5 more

March 20, 2023
Microhabitat selection in patchy environments supports the co-existence of closely related species competing for resources. We examined niche partitioning in three sympatric species of pikas, Ochotona macrotis, Ochotona nubrica, and Ochotona ladacensis from Ladakh, India, that display contrasting lifestyles, social behavior and co-occur at small spatial scales. We used a classical paired quadrat approach to document biologically relevant vegetation and landscape features (niches) likely to support the presence of different species. We used a Bayesian framework to describe niche spaces , estimate niche widths and overlaps between species pairs. In addition, we used a GLM framework to identify factors that promote the presence of different species in the landscape. The rock-dwelling Ochotona macrotis was a specialist, exclusively associated with microhabitats offering a good cover of large-sized rocks and no shrubs. The social, Ochotona nubrica, was a specialist found across elevations but associated exclusively with mature stands of scrub vegetation (Caragana sp in the South-East and Hippophae sp in the North-West) occupying a unique niche. The social Ochotona ladacensis, although an elevational specialist, was likely to be found in microhabitats of other species characterised by moderate rock cover and low-lying Caragana scrublands, in addition to being found in alpine grasslands and meadows.
Ku-band Voltage-Controlled Oscillator With Low-Dropout Based Amplitude Control
YUE-FANG KUO
Shu-Che Chang

YUE-FANG KUO

and 2 more

March 20, 2023
This letter proposes a Ku-band voltage-controlled oscillator (VCO) equipped with low-dropout (LDO) based amplitude control, fabricated in the 0.18μm CMOS process. The LDO regulator combines with the voltage distribution network to generate a stable supply of 1.8V and an internal bias voltage range of 0.64−0.72V to the VCO core. The VCO demonstrates an 11.6% tuning range from 15.69GHz to 17.62GHz. The measured phase noise of 17.62GHz carrier frequency is −111.2 dBc/Hz at 1MHz offset frequency while dissipating 3.5mA from 1.8V voltage regulator output, yielding a Figure-of-Merit of 189.4. The whole chip size is 0.6 mm2, including testing pads.
A 0.9 V Wideband SPLL With an Adaptive Fast-Locking Circuit Achieving 24.68 μs Settli...
Binghui Wang
Shu Zhou

Binghui Wang

and 2 more

March 20, 2023
A low-power wideband self-biased phase-locked loop (SPLL) is proposed for multi-protocol SerDes applications in this letter. With the proposed adaptive fast-locking current circuit (AFLCC), the settling time is reduced significantly, and no extra power and jitter contribution. In addition, a start-up module is adopted to reset the system to an optimal initial operating frequency quickly. The proposed 1-3-GHz SPLL, fabricated in TSMC 28-nm CMOS process and occupies a compact 0.028mm2 area. It achieves a roughly constant settling time of 5 μs over all frequencies and division ratios range. Only 0.96 mW is consumed from a 0.9 V supply at 1 GHz frequency.
Rising carbon uptake and sequestration but declining carbon allocation to biomass pro...
Fan Liu
Yucui Zhang

Fan Liu

and 7 more

March 20, 2023
Photosynthetically carbon (C) allocation largely determines yield and C sequestration of agroecosystem. However, how C allocation of crops responses to climate change at the long-time scale is poorly defined. Combining thirteen years of eddy covariance and inventory measurements, we comprehensively investigated C allocation mechanism in a winter-wheat and summer-maize double cropping field. Significantly increased gross primary production (GPP) was benefited from CO2 fertilization, and 35% of increased GPP transferred to strengthening C sequestration. However, elevated temperature and drying surface soil moisture stimulated the partitioning of GPP to autotrophic respiration, resulted in conservative net primary production and grain yield. Maize faced a greater risk of C loss and yield reduction than wheat to warming and drying. By synthesizing published long-term data of agroecosystems, we further highlight that the GPP partitioning cannot be simply predicted by allometric theory, particularly for grains, which should be considered in predicting C budget and crop yield.
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