Title: Reply to Migration is not the perfect answer: Optimised methodology to assess LCI agreement between corrected legacy multiple breath nitrogen washout data and that directly collected on updated software.

VACTERL association is linked to multiple congenital anomalies including tracheoesophageal fistula. In rare cases, VACTERL has been complicated by other airway malformations including severe bronchial stenosis or unilateral pulmonary agenesis. We report a child who developed episodes of oxygen desaturation during sleep associated with high pressure support requirements to maintain ventilation. He was known to have VACTERL association as well as spinal muscular atrophy (SMA) type II, a genetic neuromuscular disorder. Children with SMA can show progressive respiratory symptoms, including intercostal muscle weakness and accompanying paradoxical abdominal breathing with sparing of diaphragm function. Our patient was very difficult to ventilate non-invasively despite high pressures. CT chest with dynamic airway evaluation showed bilateral bronchial stenosis. High inspiratory pressures with non-invasive ventilation as seen in our case are required to overcome stenotic airways but are not expected in neuromuscular respiratory failure.

Artificial waterbodies can help tackle the ongoing freshwater biodiversity crisis by providing new habitat for aquatic wildlife. Farm dams are among the most abundant artificial waterbodies in agricultural landscapes, yet general guidelines for maximising their ecological potential are yet to emerge. Here we used a continental-scale dataset of frog species near 8,800 Australian farm dams to ask: What characteristics promote higher frog species richness at farm dams? The highest values of species richness were at older (>20 years) farm dams of intermediate sizes (0.1 ha in surface area), with smaller rainfall catchments (<10 ha), and near other freshwater systems or conservation sites. By identifying quantifiable features improving the ecological value of farm dams, this work helps identify “win-win” outcomes for agricultural productivity and conservation. In the future, “biodiversity credit” policies could promote large-scale implementation by rewarding farmers who invest in improving the condition of their farm dams.

Patch size and connectivity are the main predictors of population demographic and genetic stability. Habitat fragmentation continues at unprecedented rates justly affecting plant functional connectivity worldwide. However, few terrestrial plant groups have sufficiently foreshortened generation times in which to empirically disentangle the demographic and genetic consequences of reduced patch size and connectivity. Herein, we combine evidence from long-term (15 yr.) population censuses of two epiphyllous bryophytes and population genetic estimates in an experimentally fragmented Amazonian landscape to create a profile of the eco-evolutionary impacts of reduced habitat connectivity. Single nucleotide polymorphisms (SNPs) derived from Genotyping by Sequencing were used to analyze genetic patterns among fragmented (1-, 10- and 100-ha) and continuous forests. In the context of the world’s most diverse biome, fragmentation induces marked effects on plant population demography and genetic differentiation. Declines in colonization events in small patches (1- and 10-ha), associated with reduced colony densities, led to accelerated genotypic differentiation (genetic drift) compared to 100-ha fragment and continuous forests. Furthermore, the mating system was related to differential sensitivities to the intensity of fragmentation. Unexpectedly, the unisexual species (hypothesized to be more challenged in terms of spore output) was characterized by higher migration rates among smaller patches than its bisexual counterpart. These results point to the complex and unpredictable patterns revealed when life history strategies, demography, and plant genetic structure are simultaneously evaluated in the context of the long-term effects of reduced landscape connectivity.

5G network slicing is a promising solution to prioritize time-critical protection communication in wireless networks. However, recent trends indicate that a 5G slice could encompass all smart grid applications lacking the necessary granularity. At the same time, while substation communication standards recommend prioritization of protection communication traffic to improve reliability, these recommendations are only for wired connections. Therefore, this paper investigates traffic shaping and uplink (UL) bitrate adaptation of video stream based on existing commercial solutions as methodologies for prioritizing the protection communication in a 5G slice. These methodologies are validated in an experimental setup combining controller-hardware-in-the-loop (CHIL) simulation with a quality of service (QoS) measurement system. The system under test consists of commercial 5G networks, commercial intelligent electronic devices (IEDs), and merging units to validate the methodologies on three smart grid applications: fault location, line differential, and intertrip protection. The results show improvement in protection communication when traffic shaping and UL bitrate adaptation are applied. Traffic shaping even improves prioritization with a wired connection.

A document by Md Shoriful Islam. Click on the document to view its contents.

The end of the 2019/2020 influenza season was already registered in early summer 2020, and in the following season. There was an nearly complete absence of influenza. So far, the sometimes strict Covid-19 containment measures with contact restrictions and the obligation to wear a mask have been mentioned as reasons. This study looks for further reaseons and from several perspectives in order to develop strategies for a representative recording of influenza cases derive. In contrast to influenza A/B, the other viral respiratory pathogens (adenovirus, parainfluenza virus and RS virus) do not show any significant reduction. From 2020, the number of reports of respiratory infections to the RKI increased from an average of 300,000 annual reports by 2019 to 1,985,985 reports in 2020, over 5,453,017 reports in 2021 and to 29,681,158 in 2022. On the other hand cases of incapacity to work due to respiratory infections fell from 31.0% in 2019 to 15.3% in 2021. Influenza-specific diagnoses (ICD: J10.1-3) were encrypted 33,727 times in 2021, in 2020 there were still 109,846. The reduction in influenza A and B from 2020 as a result of the comprehensive Covid-19 control measures, including the obligation to wear masks, cannot be considered a major reason; rather, the aspect of underreporting of influenza cases plays a significant role. Therefore, the reporting quantity of the sentinal practices should be considered and the recording of incapacity diagnoses should be taken into account.

The irregular pulse notification (IPN) algorithm on the Apple Watch (Apple Inc., Cupertino, CA) was not designed for use by atrial fibrillation (AF) patients. It is not FDA cleared for use in AF patients. Before this study by Dr. Wasserlauf and colleagues, there were no studies of its accuracy in AF patients. Yet, many AF patients could not resist the temptation to use the feature. In the Apple Heart Study1, even after making it clear that patients with AF were not eligible for the study, 174 (18%) of the participants who received an irregular pulse notification and connected with a study visit doctor confessed that they knew they already had AF and were excluded from the study. These participants were just too curious to pass up the opportunity to see what the new technology was all about.

Maturity models guide the achievement of competency maturity levels. This study aims to develop a competency maturity model for Scrum team members in Global Software Development (GSD environments. Each Scrum role, such as Product Owner, Scrum Master, and Developers, has a unique set of competencies at each maturity level. We developed the maturity model by conducting in-depth interviews with global Scrum practitioners. We also conducted a comparative study to determine the most appropriate maturity model reference. The maturity model’s validation uses expert judgment involving experts in academia and industry. The maturity model in this study is inspired by CMMI 2.0, while Scrum and Agile Maturity models inform the maturity levels. Results reveal that each maturity level consists of a set of practice areas in which each practice area may exist in several maturity levels. The practice area contains a set of competencies with an arrangement of capability levels based on the standards by adopting the Skills Framework for the Information Age (SFIA) and the European e-Competence Framework (e-CF). In conclusion, the resulting maturity model is helpful as a guide for increasing competence gradually and measurably. This model can also develop assessment tools to measure competency maturity levels.

The human gut is colonized with microbial species that not only resides but also facilitate in many functions. The alterations in this gastrointestinal microbiota directly influence many body systems including, central nervous system (CNS) disorders such as Alzheimer’s disease (AD). The term microbiota is thus a determinant factor in the association between illness and health. AD, the most common form of dementia, is a neurodegenerative disorder associated with impaired cognition and cerebral accumulation of amyloid-β peptides (Aβ). Germ-free animals have provided enormous data on the existence of dysbiosis and its conversion by fecal microbiota transplantation. The main cause of AD is unknown and it is estimated that by 2050 the number of patients will increase up to three times. Bacteria populating the gut microbiota (GM) can secrete large amounts of amyloids and lipopolysaccharides, which might contribute to the modulation of signaling pathways and the production of proinflammatory cytokines associated with the pathogenesis of AD. The Gut-brain axis links the emotional and cognitive center of the brain with intestinal activities. Thus, it can be said that the dysbiosis of human microbiome could be a risk factor for AD. In this review, we provide an overview of GM and how their dysregulation accounts for the pathogenesis of AD. Illustration of the mechanisms underlying the modification of GM composition may pave the way for developing novel preventive and therapeutic approach for AD.

IntroductionFolliculitis is inflammation of hair follicles, most commonly due to infection. Ingrown hairs and trauma from shaving or waxing promote follicular occlusion and irritation and increase risk of folliculitis.Folliculitis is classified by depth of infection. Superficial folliculitis involves the superficial part of the hair follicle (infundibulum) while deep folliculitis involves the entire hair follicle. On examination, inflammation of superficial folliculitis is restricted to the epidermis. Deep folliculitis is distinguished by widespread erythema, edema, and tenderness involving the dermis.

This paper demonstrates the dynamic characteristics of 150-V-class GaN power HBTs for the first time. At OFF-state collector bias VCEQ = 80 V, the device shows a low dynamic specific on-resistance (RON,sp) of 0.316 mΩ·cm2, which is only 4.7% higher than static RON,sp, thanks to current conductive path far from the surface. A threshold voltage (Vth) of 3.58 V extracted at 1 A/cm2 is achieved with an on/off current ratio of 2×107. The device also show a large base voltage swing of -7 to 7 V with a small Vth hysteresis of 50 mV. The low dynamic resistance degradation, high positive Vth with low Vth hysteresis, and large base voltage swing all demonstrate the great potential of GaN HBT in power switching applications.

The integration of distributed generators (DGs) into electrical networks has become more prevalent due to their operational benefits. However, switching the DG on or off changes the fault current’s magnitude and direction, making an adaptive protection scheme (APS) necessary. This paper proposes a novel APS that optimally coordinates overcurrent relays, including Distance and directional overcurrent relays (D&DOCRs), at each transmission line’s ending near and far. This coordination problem is highly constrained and complex, involving coordinating primary and backup relays between DOCRs pairs and D&DOCRs pairs. To solve this optimization problem, the paper implements a modified Honey Badger algorithm (HBA), called CLHBA, that uses chaotic initialization and leader-based mutation selection. The proposed scheme is adaptable to changes in the electrical network’s state caused by switching the DGs on or off. The paper tests the proposed scheme on IEEE 8-bus and 14-bus distribution systems to demonstrate its ability to solve coordination problems.

Electric Vehicles (EV) have the potential to completely transform the transportation industry, slash carbon emissions significantly, and pave the road for significant climate progress. According to surveys, worries regarding range and charging accessibility are a significant barrier to EV customer adoption. The electricity grid will be significantly impacted by EV charging. A coordinated charging approach that facilitates EV charging while avoiding the power grid from overloading is required to manage EV charging. In this work, the EVs are classified based on their charging capacity. This classification includes Car, truck and bus. With this a chargingdischarging scheme has been established using Real Time Pricing (RTP) for each hour for a 20 min block. Augmenting this, in the present work the power loss is analyzed when Distributed Generation (DG) units are installed after the EVs are located in the system for charging and discharging. The DG units are installed considering the Voltage Stability Index (VSI) and the power losses incurred due to the presence of EVs. The Monetary benefit of such an investment is analyzed for different topologies of IEEE-33 and 69 bus systems and compared with the existing methods where DGs are installed before the EVs are located in the system for charging and discharging.

Climate change is increasing the weather persistence in the mid-latitudes, prolonging both dry and wet spells compared to historic averages. These newly emerging environmental conditions destabilize plant communities, but the role of species interactions in this process is unknown. Here, we tested how direct and higher-order interactions (HOIs) between species may change in synthesized grassland communities along an experimental gradient of increasing persistence in precipitation regimes. Our results indicate that species interactions (including HOIs) are an important determinant of plant performance under increasing weather persistence. Out of the 12 most parsimonious models predicting species productivity, 75 % contained significant direct interactions and 92 % significant HOIs. Inclusion of direct interactions or HOIs respectively tripled or quadrupled the explained variance of target species biomass compared to null models only including the precipitation treatment. Drought dominated the plant responses, with longer droughts increasing direct competition but also HOI-driven facilitation. Despite these counteracting changes, drought intensified net competition. Grasses were generally more involved in competitive interactions whereas legumes had a stronger affinity for facilitative interactions. Under longer drought, species affinity for nutrient rich or wet environments resulted in more negative direct interactions or HOIs, respectively. We conclude that higher-order interactions, crucially depending on species identity, only partially stabilize community dynamics under increasing weather persistence.

Klebsiella variicola (K. variicola) is an emerging human pathogen, which poses a threat to public health. The horizontal gene transfer (HGT) of plasmids is an important driver for the emergence of multiple antibiotic-resistant K. variicola. The clustered regularly interspersed short palindromic repeats coupled with the CRISPR-associated genes (CRISPR/Cas) constitute an adaptive immune system in bacteria, which provide acquired immunity against HGT. However, the information about CRISPR/Cas system in K. variicola is still limited. In this study, a total of 487 genomes from NCBI database were used to analyze the characterization of CRISPR/Cas systems. 105 of the 487 genomes harbored at least one confirmed CRISPR array. Three types of CRISPR/Cas system, including types I-E, I-E*, and Ⅳ-A systems, were identified among 105 strains. The distribution of type I system was strongly associated with MLST, whereas type IV system was randomly distributed. Approximately one-third of spacer origins were homologous with plasmids or phages, indicating the role of CRISPR/Cas systems in controlling HGT. Moreover, spacers in K. variicola tended to target mobile genetic elements (MGEs) from Klebsiella pneumoniae, which provides new evidence for their interaction during evolution. Collectively, our results provide valuable insights into the role of CRISPR/Cas systems in K. variicola.

A document by Abul Hasan. Click on the document to view its contents.

A document by Tim Xiao. Click on the document to view its contents.

Rationale: Industrial TNT contains substances other than 2-4-6-trinitrotoluene that are of primary interest for military applications. The degradation of industrial TNT by aging and by contact with steel surfaces, which represent real situations of use of the material, was investigated. There is practical knowledge about this degradation, but the literature lacks details of this process. Methods: Small steel samples used in military ammunition were covered with TNT and heated at 75 ºC for 30 days under vacuum. Some of the samples were previously painted with a red alkyd paint coating that protects the metallic surface. After aging, the TNT was scraped off the metal pieces and analyzed by scanning electron microscopy, Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry. Results: The results showed in detail how the integrity of the TNT is maintained even under thermal stress and in contact with the steel surface. Although some changes were observed in the surface appearance of the TNT, all the analyses indicated the maintenance of the chemical integrity of the industrial TNT. The only change in composition identified is related to the contamination with degradation products of the alkyd paint coating and not with the degradation processes of the TNT itself. Conclusions: Our results indicated that although there are many TNT degradation processes reported in the literature, for cases involving thermal stress degradation of TNT in solid phase in contact with metal, these processes are irrelevant. Thus, it is possible to elucidate the safety of TNT when packaged in steel artifacts, which represent the majority of military ammunition.

Background Provide a brief overview of recent technological advances that can potentially give information for treatment of different kind of arrhythmias. Methods In this report, we describe the features of Omnipolar technology (OT) using high density mapping catheter and we report five different scenario in which this new tool can give some important information to understand arrhythmia’s substrate and guide the treatment. OT combine three unipolar and two bipolar signals and provides maximum voltage regardless of electrode-wavefront orientation, local wavefront activation direction and local measurements of wave speed: it allow to create a velocity map. Results OT has been used to study different types of supraventricular tachycardias. Regarding reentry tachycardias, velocity map has allowed the characterization and definition of the impulse velocity along the dual nodal pathway and the accessory pathways (AP). As regards atrial flutter, it has successfully allowed the definition of the slowest zone of the critical isthmus and radiofrequency (RF) delivery at that point resulted in termination of the arrhythmia. During mapping of the left atrium in sinus rhythm, the velocity map allowed the identification of the course of the Bachmann’s bundle, which could potentially play a role during the ablation of persistent atrial fibrillation (AF). Conclusion OT and velocity map offer significant advantages in the management of challenging arrhythmias, and can potentially improve the efficacy of the treatment of some arrhythmias such as atrial flutter and AF.

Wearable electronics are expected to be light, durable, flexible, and comfortable. Many fibrous, planar and tridimensional structures have been designed to realize flexible devices that can sustain geometrical deformations, such as bending, twisting, folding, and stretching normally at ambient conditions. As a flexible electrode for batteries or other devices, it possess favorable mechanical strength and large specific capacity and preserve efficient ionic and electronic conductivity with a certain shape, structure and function. To fulfill flexible energy-storage devices, much effort has been devoted to design of structures and materials with mechanical characteristics. This review attempts to critically review the state‐of‐arts with respect to materials, and structural design of devices as well as applications of the wearable electronic products. Finally, discussion present regarding to limitations of current materials, fabrication techniques, devices concerning manufacturability and performance as well as scientific understanding that must be improved prior to their wide adoption.

The increase in fossil fuel consumption used in conventional vehicles has adversely affected the amount of carbon emissions in the atmosphere. Due to this negativity, many problems such as global warming, noise pollution and cost have emerged. In order to find solutions to these problems, many studies have been carried out to increase the energy storage capacity of Electric Vehicles (EV) since 1835. EVs produced as a result of these studies work more efficiently than traditional tools. However, the driving range problem and charging time are the biggest disadvantages of these vehicles. These disadvantages are a major obstacle for EVs to replace traditional tools. In this study, an experimental study was conducted on flywheel-battery in-vehicle topologies, which are recommended to be used to increase the range in EV and hybrid electric vehicles. In the application, two flywheels with the same rotor radius and different masses were used. Energy was produced from the generator through these flywheels. This energy was employed to charge the batteries. The stored energy and power amounts were investigated depending on the variation of the moment of inertia of both flywheels at the maximum and minimum levels. As a result of this examination, it has been determined which of the flywheels with the same rotor radius but different masses is more suitable for electric vehicles.

Acenocoumarol is the most widely prescribed vitamin K antagonist (VKA) to prevent and treat thromboembolic disorders. It keeps a major place in many indications despite the introduction of new direct oral anticoagulants (DOACs). However, a narrow therapeutic range, an intra-individual variability and drug interactions may lead to serious adverse drug reactions.  Sometimes, a genetic or acquired resistance to this drug may lead to a risky situation. Hopefully, resistance to acenocoumarol is a very rare phenomen.Here in we present an unsusual case of a suspected resistance to acenocoumarol. This case was notified to the Tunisian National Center of Pharmacovigilance on October 2017 and registered under the number 2449/2017. A 67-year-old patient with hypertension, diabetes, and coronary disease was treated with captopril, atenolol, atorvastatin, and salicylic acid. In 2017, acenocoumarol treatment was introduced. At biological control, the prothrombin time (PT) was 100%. The doses of acenocoumarol were raised progressively with iterative controls of PT. PT was always 100% even when acenocoumarol reached the dose of 2 g/day. A resistance to acenocoumarol was suspected. The patient was referred to pharmacovigilance department for case analysis. During the patient interview, we discover that the patient was confusing acenocoumarol with atenolol. In fact, when his doctor was increasing the doses of acenocoumarol, the patient increased her intake of atenolol believing that it was acenocoumarol. A resistance to acenocoumarol was eliminated in this patient since she had never taken the drug. We highlight through this case the importance of patient’s interview. Explaining the indications and the potential adverse events of the drug to patients taking VKA is crucial to ensure a better efficiency of treatment without increasing the risk of bleeding complication.

In China, 1100 ng/mL is used as the recommended threshold for imatinib Cssmin in therapeutic drug monitoring (TDM) for metastatic recurrence/unresectable gastrointestinal stromal tumors (GIST) patients. However, there are few studies on characteristics of imatinib Cssmin for adjuvant therapy after complete resection of GIST and neoadjuvant therapy. Consider individual differences of GIST patients, analysis of imatinib in patients with adjuvant and neoadjuvant treatment using a quantitative ultra-performance liquid chromatography coupled with tandem massspectrometry (UPLC-MS/MS) method was conducted in this study. This developed method showed good selectivity and reliability. 25 blood samples collected from October 2019 to October 2021 in 16 patients with adjuvant therapy and 9 patients with neoadjuvant therapy were determined. In the neoadjuvant treatment group, all patients initially received 400 mg/d imatinib. The range of the imatinib steady-state plasma concentration (Cssmin) was 1083-4722 ng/mL. In the adjuvant treatment group, the imatinib Cssmin was in the range of 584-2692 ng/mL after patients given at a dosage of 200, 300, 400 and 600 mg/d. There is no statistical difference in Cssmin between two groups after receiving 400 mg/d imatinib (p=0.402). Among all patients given 400 mg/d imatinib, the Cssmin was significantly correlated with gender (P=0.016).