The development of the OH- sieving membranes is of extraordinary importance but challenging for treating alkaline effluents. Here, we propose the ionization engineering concept of two-dimensional (2D) laminated membranes to pursue promising OH- separation. This concept is exemplified via stacking the self-designed sulfonated graphene oxide (SGO) nanosheets to fabricate 2D membranes. The SGO membranes achieve synergetic improvements of OH- dialysis coefficients and separation factors towards the simulated NaOH/Na2WO4 alkaline wastewater in sharp contrast to the 2D GO membranes and the commonly adopted polymeric cation exchange membranes. Besides, the separation factor of the SGO membranes is far higher than most the existing alkali recovery membranes. The molecular dynamics simulation results hint the high-efficiency OH- separation originates from the 2D SGO confined channels, where the dehydration effects and intensified electrostatic repulsion jointly play critical roles. This study offers an alternative strategy to achieve fast OH- sieving by ionizing 2D confined channels.

The fragmentation/adhesion behavior of nanoparticle agglomerate collision, which is challenging to model, is a crucial factor affecting fluidization. In this study, a discrete-finite element method (FDEM) based cohesive crack model is developed to simulate normal collisions between a complex agglomerate (around 1 mm) and a wall. In the FDEM model, the complex agglomerate is built from primary agglomerates (around a few micrometers), whose adhesive force and Young’s modulus are measured by an atomic force microscope (AFM). Simulation results agree well with the collision experiments. Furthermore, the effects of adhesive force, solid holdup and Young’s modulus on fragmentation behavior are explored, and a two-parameter Weibull function is found to fit well with the fragment distribution. The current FDEM model provides a link between the collision behavior and agglomerate properties. The detailed fragmentation/adhesion information can be useful for developing a macro model for agglomerate collision in the future.

Conductive polypyrrole is a kind of conductive polymer, which belongs to composite intelligent driving materials. The actuator based on Ppy has the advantages of low driving voltage, large output displacement, high flexibility, and so on, and has broad application in the field of bionic robots and micro actuators. It is essential to know the actuator‘s behavior from experiments. In this paper, the application of conductive Polypyrrole in actuators was researched and simulated. Single PPy actuator was tested by loading different numbers of magnet balls. The test results showed that the output force of the single conductive polypyrrole is greater than 0.4712mN. In order to improve its application ability, a four-claw gripper that integrates four PPy actuators was designed and tested, the experiment shows that the output force of the gripper is greater than 0.298mN.

A document by Hessam Ghassemof. Click on the document to view its contents.

Generic descriptions (e.g., “girls are emotional”) are argued to play a major role in the development of essentialist reasoning about social categories (Rhodes et al., 2018). However, studies have been conducted dominantly in English-speaking communities and among Western samples. This is a significant limitation given that a number of theories focus on the linguistic form of generic statements and distinguish between form and content in leading to essentialism. In this study, we plan to extend the research on generics and social essentialism beyond English-speaking, Western samples. We aim to explore how generic statements with different content (biological or cultural) about a novel social category may lead to essentialist beliefs among children and adults in Iran, a Persian-speaking community that is underrepresented in the literature. Using a design similar to Noyes & Keil (2020), we plan to expose 4 to 9-year-old children (N = 104) and adults (N = 104) to generic or specific statements (between subjects) ascribing biological or cultural features to a novel social category. We will measure the degree to which exposure to these statements leads to essentialist reasoning in terms of inheritability and “kindhood”. This work contributes to diversifying the field and informs theories of social essentialism.

Background: Concerns of COVID-19 vaccine safety from pregnant women still widespread. We used transcriptomic profile analysis to study changes of the maternal-fetal interface after vaccination and explore the possible protective effects from vaccination against miscarriage. Methods: We collected decidual tissuesafter uterine curettage from pregnant women in the first trimister with (n = 6) and without a COVID-19 vaccination (n = 6) and performed RNA-sequencing. Furthermore, we ananlyzed our transcriptome datas of samples and other datasets about maternal-fetal interface and miscarrige to analyze the potential link by bioinformatics tools. Results: We identified 879 different expressed genes from pregnant women who received vaccination and found that the COVID-19 vaccine could alter some hazardous RSA-related genes, such as CXCL11, FOS, FOSB, LY96, MMP10, and NCF2. Vaccination also changed some hazardous RSA-related signaling pathway.These molecules induced the transformation of M2 macrophages and promoted the balance of Th1/Th2 immune responses. Finally, these effects on the immune microenvironment of the maternal-fetal interface also showed corresponding positive changes. Conclusion: Many RSA-related signaling molecules were reversed after COVID-19 vaccination, indicating that the vaccine did not cause RSA, and these molecules ultimately may have protective effects on miscarriage by influencing the immune microenvironment at the maternal-fetal interface.

The spatio-temporal land cover dynamics of a medium‐size floodplain system along the Amazon/Solimões River (Janauacá Lake, 786 km 2) and their hydrological impacts are studied through remote sensing and modeling. Hence, the analysis of 5 satellite-derived land cover maps (1972-2016 period) reveals a decrease in natural environments (from 65% to 35%) to the benefit of anthropic classes (from 17% to 51%) through deforestation vectors (two highways and lake banks). Deforestation is a non-stationary process with significant increase over specific subperiods (1972-1986, and 2005-2016). It occurs in stages with conversions into secondary vegetation then into non-natural environments. 7 land cover scenarios (5 satellite-derived, 1 deforested and 1 forest, used as reference) are used as inputs to run simulations with the same meteorology over the 2006-2018 period. Beside high ( ≥ 24%) and low ( ≤ 7%) interannual variability of runoff-rainfall ratio (RRR) and evapotranspiration (ET), the numerical experiments evidence, on an annual scale, the RRR decreases and the ET increases with deforestation increases. Deforested scenario suggests a convergence: for the RRR, around 0.34 (-87%) and for the ET, around 1146 mm.yr -1 (+6%). At the seasonal scale, the landuse/landcover changes (LUCC) induce positive wet season ET anomaly (<9%) and large negative dry season RRR anomaly (-87%). The highest LUCC-induced disturbances (from -15% to 18%) in the FP mixture are recorded at seasonal scale, during LW and RW and, at interannual scale, during dry and normal HY. The LUCC-induced disturbances patterns of FP mixture mainly concern river and runoff. They are different regarding the hydrological period or HY type. Our experiments suggest the existence of a tipping point between present land cover (2016) and fully deforested cover associated with reversal phenomena and enhancing of seasonal and interannual LUCC-induced disturbance. At last, the model shows the LUCC augment the vulnerability associated with drought periods.

Background Noninvasive assessment of elevated filling pressure in the left ventricle (LV) remains an unresolved problem. Of the many echocardiographic parameters used to evaluate diastolic pressure, the left atrial strain and strain rate (LA S/SR) have shown promise in clinical settings. However, only a few previous studies have evaluated LA S/SR in larger populations. Methods A total of 2033 participants from Norwegian (Tromsø 7) and Russian (Know Your Heart) population studies, equally distributed by age and sex, underwent echocardiography, including atrial and ventricular S/SR and NT-proBNP measurements. Of these, 1069 were identified as healthy (without hypertension, atrial fibrillation (AF), or structural cardiac disease) and were used to define the age- and sex-adjusted normal ranges of LA S/SR. Furthermore, the total study population was divided into groups according to ejection fraction (EF) ≥50%, EF <50%, and AF. In each group, uni- and multiple regression and receiver operating characteristic curve analyses were performed to test LA and LV functional parameters as potential indicators of NT-proBNP levels above 250 ng/ml. Results The mean LA S/SR values in this study were higher than those in previous large studies, whereas the lower references were comparable. In normal hearts, atrial total strain (ATS) and mitral valve E deceleration time (MV DT) were independent factors indicating elevated NT-proBNP levels, whereas in hearts with reduced EFs, the independent indicators were peak atrial contraction strain (PACS) and LV stroke volume. The areas under the curve for these significant indicators to discriminate elevated NT-proBNP levels were 0.639 (95% confidence interval (CI): 0.577-0.701) for normal EF and 0.805 (CI: 0.675-0.935) for reduced EF. Conclusion The results confirm good intrastudy reproducibility, with mean values in the upper range of previous meta-analyses. In the future automated border-detection algorithms may be able to generate highly reproducible normal values. Furthermore, the study showed atrial S/SR as an additional indicator of elevated NT-proBNP levels in the general population, demonstrating the incremental value of both ATS and PACS in addition to conventional and ventricular strain echocardiography. Thus, the LA S/SR may be regarded as an important addition to the multiparametric approach used for evaluating LV filling.

Background Thymic stromal lymphopoietin (TSLP), a pleiotropic cytokine mainly expressed by epithelial cells, plays a key role in asthma pathobiology. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP), overlapping the lfTSLP C-terminus. Macrophages (HLMs) and mast cells (HLMCs) are in close proximity in the human lung and play central roles in different asthma phenotypes. Methods Immunofluorescence and Western blot were employed to localize intracellular TSLP. Limited proteolysis and mass spectrometry allowed the identification of cleavage sites of TSLP caused by tryptase and chymase. ELISA assays were employed to measure TSLP and VEGF-A. Results TSLP was detected in highly purified (≥ 99%) macrophages isolated from human lung and subcellularly localized in the cytoplasm by confocal microscopy and Western blot. IL-4 and lipopolysaccharide induced the release of TSLP from HLMs. HLMCs contain and release tryptase and chymase that specifically cleaved TSLP. Mass spectrometric analyses of TSLP treated with tryptase showed the production of 1-97 and 98-132 fragments. Chymase treatment of TSLP generated two peptides 1-36 and 37-132. HLM activation by lfTSLP induced VEGF-A, the most potent angiogenic factor, release. The four TSLP fragments generated by tryptase and chymase failed to activate HLMs. sfTSLP neither activated HLMs nor interfered with activating property of lfTSLP on HLMs. Conclusions Given the close proximity between mast cells and macrophages in the human lung, our results illuminate a new circuit between HLMs and mast cells. These findings have potential relevance in understanding novel aspects of asthma pathobiology.

Two pairs of cobalt(II) complexes with formulas of [Co(3,5,6-tcpa)(2,2’-bipy)Cl] (1A), [Co(3,5,6-tcpa)2(2,2’-bipy)]n (1B), [Co(3,5,6-tcpa)2(4,4’-bipy)(EtOH)]n (2A) and [Co(3,5,6-tcpa)2(4,4’-bipy)(EtOH)2]n (2B) have been cocrystallized by the solvothermal reaction of cobalt chloride hexahydrate with triclopyr (2-((3,5,6-trichloropyridin-2-yl) oxy)acetic acid, 3,5,6-Htcpa) and 2,2’-bipyridine (2,2’-bipy) or 4,4’-bipyridine (4,4’-bipy) coligands. Single-crystal X-ray diffraction analysis indicated that both 1A and 1B crystallized in triclinic system, space group P (no. 2). Compound 1A is mononuclear and 3,5,6-tcpa anion in it is a bidentate chelate ligand, while 1B is a 1D double-stranded chain structure in which 3,5,6-tcpa are bidentate bridging-μ2 linkers. In contrast, 2A has orthorhombic system, space group Aea 2(no. 41) and 2B showed monoclinic system, space group I2/a (no. 15). Complex 2A displays a 1D linear chain but 2B presents a zigzag chain, and 3,5,6-tcpa are both unidentate in them. The non-covalent interactions of Cl•••Cl/O halogen bonds, H•••O/Cl hydrogen bonds and/or π•••π stacking interactions play an important part in their crystal packing, which have been confirmed by the careful Hirshfeld surface analyses. It was proposed that flexible conformation alteration of 3,5,6-tcpa might be in charge of the cocrystallization phenomenon for 1A, 1B and 2A, 2B. The magnetic characterizations suggested antiferromagnetic coupling between neighbouring cobalt(II) centers both for 1B and 2B.

Rationale: Trimetazidine and its metabolites are prohibited substances in sports. With a growing number of adverse findings in human athletes, it is crucial to develop doping control strategies that include screening for trimetazidine in animal sports. This study aims to detect and characterize trimetazidine and its metabolites for doping control in camel racing. Methods: Camel urine and plasma samples were collected from four healthy animals following a single oral dose of trimetazidine. invitro studies utilized camel liver cells. Liquid-liquid extraction (LLE) and solid-phase extraction (SPE) techniques were employed for the extraction of trimetazidine metabolites from plasma and urine matrices, the metabolites were analyzed using a thermo Orbitrap exploris LCMS system with optimized settings to achieve maximum sensitivity and accurate mass measurements. Results: Comprehensive metabolite profiling of trimetazidine in camels revealed the identification of seven phase I and five phase II metabolites. Phase I metabolites were primarily formed through delakylation, while phase II metabolites were dominated by glucuronide conjugation of demethylated trimetazidine. The findings provided insights into the distinct metabolic pathways and biotransformation patterns of trimetazidine in camels under the experimental conditions. Conclusion: The developed method enables detection and characterization of trimetazidine and its metabolites in camels. The identified metabolites have the potential to serve as biomarkers for trimetazidine abuse in camel racing .this study provides valuable insights into the metabolism of trimetazidine in camels.

A 59-year-old male was incidentally diagnosed with a left atrial mitral valve chordae involving the junction of the A1 and A2 mitral valve leaflets and resulting in moderate mitral regurgitation. The recognition of this extremely rare congenital malformation prevented over diagnosis and overtreatment.

Automating the generation of questions to assess students remains a serious scientific problem in developing country. Several works have been carried out on the subject but, to date, the automation of the correction of the questions generated, their connection to identified educational objectives, their ability to address comprehension problems, the definition of their difficulty and the response time remain points that are not very much addressed. In developing countries, this problem is even more accentuated by the massification due to overstaffing. This article presents a mathematical logic question generator that provides the generation and correction of questions linked to objectives, testing comprehension, with the possibility of calculating a level of difficulty and automatic scoring using the connectors and quantifiers making up the question. This generator uses automatic language processing techniques based on rules, as well as a formalization of learning objectives allowing correspondence with the generated questions. The test of the generator among mathematics students shows that 100% of the automatically generated questions comply with the objectives for which they were generated. About 90% of generated questions are syntactically and semantically well-formed

A document by Anindya Ghosh. Click on the document to view its contents.

Rational bilinear difference equations are very popular in research. In this paper the asymptotic properties of a rational bilinear difference equation are studied under stochastic perturbations. It is assumed that stochastic perturbations are proportional to the deviation of the current value of the equation solution from one of its equilibria (the zero or nonzero). Some conditions are obtained under which the considered equilibrium is stable in probability or unstable. The obtained results are illustrated by numerical simulation of solutions of the considered stochastic difference equation. It is noted that the research method used here can be applied to study many other types of nonlinear difference equations. To readers attention some unsolved problem of stabilization by noise for stochastic difference equations is also proposed.

In this investigation, pitting corrosion methods were used to investigate the corrosion behaviour of nanographene oxide-reinforced aluminium-copper metal matrix composites. S1 (AL 100% + 0% Cu + 0% Nano Graphene), S2 (AL 91% + 7% Cu + 2% Nano Graphene), S3 (AL 82% + 14% Cu + 4% Nano Graphene), and S4 (AL 73% + 21% Cu + 6% Nano Graphene) were the sample compositions. Ultrasonic stir casting was utilised to produce the aluminium-copper-nanographene composites. Nanographene was analysed with BET to determine its surface area, porosity volume, etc. The effects of nano graphene oxide weight fraction on the corrosion behaviour of aluminium-copper composites were investigated. The surface texture of the corroded material was evaluated with an atomic force microscope, and the hardness was measured with a Vicker’s microhardness tester. The results of the experiment revealed that the corrosion rate decreased as the percentage of nanoparticles in the matrix increased up to S3 composition. The microhardness values increased as the weight fractions of reinforcements in the matrix increased. And additional mechanical tests, such as tensile, wear, and flexural, to ascertain the composites’ mechanical behaviour

This paper proposes a novel voting system that incorporates an intersectional Privilege Index to address social inequalities and power imbalances that often lead to marginalized groups being underrepresented in the political sphere. The Privilege Index is a composite measure that takes into account various factors, such as race, gender, socioeconomic status, and education, which contribute to an individual's social privilege. By incorporating this index into the voting process, the proposed blockchain-based system aims to counteract the effects of systemic inequalities and ensure that underrepresented groups have a more significant impact on the outcome of elections and other democratic processes. This paper provides a comprehensive analysis of the proposed Privilege Index-based voting system, outlining its design, potential benefits, and associated ethical, legal, and practical challenges. The system incorporates zero-knowledge proofs to protect the privacy of citizens' personal information and assigns a vote token based on the Privilege Index score. During the voting process, citizens burn their vote tokens to cast their ballots, and the final results are determined by the sum of the token values for each candidate or option. Despite the potential benefits of the Privilege Index-based voting system, it also raises several ethical, legal, and practical challenges that must be carefully considered, such as accuracy of the Privilege Index, privacy concerns, potential for manipulation, legal and ethical considerations, and practical challenges. This paper examines these challenges and presents strategies for mitigating them to ensure a fair and inclusive democratic process.

The perception of two (or more) simultaneous musical notes, depending on their pitch interval(s), could be broadly categorized as consonant or dissonant. Previous literature has suggested that musicians and non-musicians adopt different strategies when discerning music intervals: musicians rely on the frequency ratio (defined as the relative ratio between the two fundamental frequencies, such as 3:2 (C-G), perfect fifth/consonant; vs. the mixtures of semitones, as 45:32 (C-#F), tritone/dissonant) for the musicians; and non-musicians on frequency differences (e.g., the presences of beats, perceived as rough), and their separate ERP differences in N1(~160ms) and P2(~250ms) along the midline electrodes. To replicate and extend, in this study we reran the previous experiment, and separately collected fMRI data of the same protocol (with sparse sampling modifications). The behavioral and EEG results to a large extent corresponded to our previous finding. The fMRI results, with the joint analyses by univariate, psycho-physiological interaction, multi-voxel pattern analysis, and representational similarity analysis (RSA) approaches, further reinforce the involvement of midline and related-brain regions in consonant/dissonance judgments. The final spatio-temporal searchlight RSA provided convincing evidence that medial prefrontal cortex, along with bilateral superior temporal cortex, as the joint locus of midline N1, and dorsal anterior cingulate cortex for the P2 effect (for musicians). Together, these analyses not just reaffirm that musicians rely more on top-down knowledge for consonance/dissonance perception; but also demonstrate the advantages of multiple analyses in constraining the findings from both EEG and fMRI.

Opioid addiction causes mood disorders and increases anxiety, depression, and cognitive impairment. Valproate exerts a neuroprotective effect preventing damage and neural degeneration in epilepsy. The animals were randomly divided into four groups (n=6). The control and valproic acid (VPA) groups were injected intraperitoneally with saline or valproic acid respectively. In the morphine sulfate (MOR) group, animals were injected subcutaneously with morphine sulfate. The MOR + VPA group received two injections of drugs, valproate, and morphine, as well as the VPA and MOR groups. All intraperitoneal and subcutaneous injections were done for 8 days. The animals were assessed on day 8 to behavioral tests. The administration of valproic acid and morphine was discontinued from day 8 and the animals entered spontaneous withdrawal syndrome. The behavioral tests were repeated on day 11. Results showed that PI% decreased in NORT in the VPA, MOR, and MOR + VPA groups compared with the CTL group in the withdrawal phase. The concomitant administration of VPA and morphine caused an increase in social interaction criteria in both the chronic and withdrawal phases. The decrease in immobility time of the VPA and MOR + VPA groups compared to the CTL group in the withdrawal phase was not statistically significant in the tail suspension test. The VPA can be assessed based on the degree of anxiety and depressive behaviors caused by the withdrawal syndrome. Therefore, reducing stress in rats during morphine withdrawal may be part of the beneficial effects of VPA in improving social relationships and depression indices.

Cow dung (CD) benefits nature with its exclusive properties, anti-fungal, anti-bacterial, biofertilizer, pesticide, microbial and soil fertility booster due to its physicochemical properties. CD promotes diverse microflora and macrofauna. Coprophils inhabit to condition the dung for the other decomposers. Some species of them are similar in distant nations promising the reliability of CD property. The intra-specific competition between the fungal colony is substantial to ensure the dominant phyla over decomposition. Besides, bacteria colonize before fungi due to their survivability in high moisture, thus, preparing the CD for the growth of coprophils. Generally, these two microflora colonies communicate to ensure their dependency on CD (endosymbiosis, competition, detoxification, pathogenicity, and mycelial interactions). The anti-fungal and anti-bacterial properties of CD may be due to the antagonistic relationship of fungal-fungal or fungal-bacterial association in CD. Among the dung arthropods, dung beetles are crucial due to their bigger size, diverse gut microbiota, and rolling and burrowing strategies to permit the colonization of microbes. Furthermore, the earthworms aggregate under CD upon deposition and complete the biogeochemical process by casting and conditioning to make the nutrients available for plant intake. They also restore soil fertility by vermicomposting and enhances their relationship with dung beetles and microbial population.

Objective: The objective of this study was to develop the Menstrual Migraine Symptoms Scale (MMSS). Methods: The study utilized a robust methodological design with a sample size of 582 participants. The data underwent a comprehensive analysis employing various statistical techniques, including item analysis, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), Cronbach’s alpha internal consistency coefficient, and the Intraclass Correlation Coefficient (ICC) for test-retest reliability. To collect the study data, Google Forms was employed for both the Socio-Demographic Characteristics Form and the MMSS. Results: The two sub-dimensions of the scale, consisting of 19 items, demonstrated excellent internal consistency, with Cronbach’s alpha coefficients ranging from 0.932 to 0.970. Furthermore, the total scale exhibited a high level of internal consistency, with a Cronbach’s alpha coefficient of 0.976. The item correlation values within the scale ranged from 0.741 to 0.921, indicating strong relationships between the items. Following the identification of the factor structure through EFA, the construct validity of the scale was further assessed using CFA with an additional dataset. The results of the CFA demonstrated that the scale performed exceptionally well across all evaluation metrics, affirming its reliability and validity as a measurement tool with a robust two-factor structure. Conclusion: The study findings conclusively demonstrated the validity and reliability of the MMSS as a robust measurement tool specifically designed for assessing female individuals. With its proven accuracy and consistency, the scale can be confidently employed to reliably evaluate and monitor menstrual migraine symptoms in women.

Objective: To evaluate the risk of maternal death following the intensification of Maternal and Perinatal Death Surveillance (MPDSR) activities and the substitution of dinoprostone for misoprostol for labour induction. Design: Case-cohort Setting: Kiambu County Referral Hospital(KCRH), Kiambu County, Kenya Population or Sample: Mothers delivering at KCRH during January 2018 - December 2021 Methods: We recruited all 58 mothers who died between January 2018 and December 2021 as cases. A random subcohort of 232 mothers who did not die was selected from a retrospective cohort study of 411 mothers as controls. Multiple logistic regression was used to model the determinants of maternal mortality adjusted for intensified MPDSR activities and labour induction agents. Main Outcome Measures: Adjusted odds ratio of maternal mortality for mothers induced with misoprostol versus dinoprostone and for delivery prior to and after the intensification of MPDSR activities. Results: Factors associated with increased risk maternal mortality included: unemployment (AOR 1.83; 95% C.I.: 0.52 – 7.50), singlehood (AOR 3.47; 95% C.I.: 0.59 – 17.9), labour induction with misoprostol (AOR 7.17; 95% C.I.: 0.72 - 182), multiparity (AOR 3.11; 95% C.I.: 1.37 – 6.98, p = 0.006), or being pre-term (AOR 4.79; 95% C.I.: 1.56 – 15.7, p = 0.007). Conclusions: The risk of maternal mortality did not decrease with the intensification of MPDSR activities but increased with the use of misoprostol to induce labour. Funding: Ministry of Health (Kenya), Transforming Health for Universal Health Coverage

Hodgkin Lymphoma (HL) is a common malignancy in adolescents. For relapsed/refractory disease many regimens have been proposed and novel agents are increasingly used. Brentuximab Vedotin (BV) is an antiCD30 antibody-drug conjugate used as single agent or in combination with classical regimens mainly in adults, while limited is the experience in paediatrics. We report here on two boys with aggressive and high-risk relapsed HL, successfully treated with the BV plus DHAP regimen as induction salvage treatment. Our experience provides initial real-world evidence on the use of BV-DHAP as first-line salvage therapy for high-risk relapsed/refractory HL and expands the current therapeutic choices.

The phenotypic diversity resulting from the domestication of sheep has made a significant contribution to human civilization. Hu sheep are a local sheep breed unique to China. Here, we conducted whole-genome sequencing of 207 Hu sheep and compared them with the wild ancestors of domestic sheep (Asian mouflon) to investigate the sheep’s genetic characteristics and selection signatures. Based on six signatures of selection approaches, we detected genomic regions containing genes related to reproduction (BMPR1B, BMP2, PGFS, CYP19, CAMK4, GGT5, and GNAQ), vision (ALDH1A2, SAG, and PDE6B), nervous system (NAV1), and immune response (GPR35, SH2B2, PIK3R3, and HRAS), which could potentially be a target relevant to the domestication and selection of Hu sheep. Association analysis revealed that missense mutations in the GPR35 (GPR35 g.952651 A>G; GPR35 g.952496 C>T) and NAV1 (NAV1 g.84216190 C>T; NAV1 g.84227412 G>A) genes were significantly associated (P < 0.05) with immune and growth traits in Hu sheep populations, respectively. This research offers novel insights into Hu sheep selection characteristics during domestication and facilitates further genetic improvement and molecular investigations.