Recent rapid growth in perovskite solar cells (PSCs) has sparked research attention due to their photovoltaic efficacy, which exceeds 25% for small-area PSCs. The perovskite film’s optical and electrical properties, including as light absorption, carrier diffusion length, and charge transport, are directly controlled by its shape. Therefore, this review begins with the structure of perovskite solar cells and highlights the latest film production technologies and how film morphology affects performance. To commercialize PSCs and enhance scalability, several technologies have been devised to make high-quality perovskite films. Spin coating, chemical vapor deposition, blade-coating, spray coating, flexographic printing, screen printing, and inkjet printing have been shown to manage film formation and improve power conversion efficiency (PCE) by over 21%. Large-scale production is feasible with chemical vapour deposition and thermal vapour deposition despite their complex technological requirements and high reproducibility of processing and manufacturing. We concluded by reviewing perovskite solar cell fabrication methods and commercialization prospects. To commercialize perovskite solar cells, existing fabrication technologies need to be refined and more studies should be done.

Abstract Background: The purpose of this meta-analysis was to look at the relationship between hypernatremia and mortality in COVID-19 patients. Methods: We searched the PubMed, Web of science, Embase and Cochrane databases for articles published from the inception of the database until August 27, 2022. Three researchers reviewed the literature, retrieved data, and assessed the quality of the literature, respectively. A meta-analysis was performed using State 17 software to assess the value of the effect of hypernatremia on mortality in patients with new coronavirus pneumonia. Results: A total of 9 publications was finally included in this study, including a total of 11,801 patients with COVID-19, including 1,278 in the hypernatremia group and 10,523 in the normonatremia group. Meta-analysis showed that hypernatremia was associated with mortality in patients with COVID-19 [OR = 4.15, 95% CI (2.95-5.84), P = 0.002, I² = 66.7%] with a sensitivity of 0.36 [0.26, 0.48] and a specificity of 0.88 [ 0.83, 0.91]. The posterior probability of mortality was 42% in patients with COVID-19 hypernatremia and 15% in patients who did not have COVID-19 hypernatremia. Conclusion: According to available data, hypernatremia is associated with death in patients with COVID-19.

The purpose of this study was to study the effect of high oxygen concentration on bituminous coal oxidation. The ignition point data under corresponding conditions were obtained by comparing thermogravimetric experiments and large-scale pyrolysis experiments. Oxidized coals with different oxygen concentrations and temperatures were collected by large-scale pyrolysis experiments and extracted with chloroform. The extracted liquid samples were analyzed by GC-MS and Fourier transform infrared spectroscopy. The extracted oxidized coal was characterized by Fourier transforms infrared spectroscopy. The results show that the ignition temperature measured by the large-scale pyrolysis experiment is more than 200 °C lower than that measured by the thermogravimetric experiment at 20% oxygen concentration. The oxidation activity of coal decreases first and then increases with the increase in temperature. The ether bond formed below 150 °C is oxidized and exothermic above 175 °C, which is likely to be the direct cause of coal seam fire.

In the current project, we describe a green, simple, and eco-friendly procedure for the oxidation of aromatic alcohols into benzaldehydes derivatives with a new Fe3O4@CS@γ-Al2O3 nanocomposite and H2O2 as the sole oxidant for the first time. The catalytic performance of Fe3O4@CS@γ-Al2O3 composites as heterogeneous nanocatalysts were studied in the selectively oxidized benzyl alcohols to generate relevant benzaldehyde. Also, the functional parameters of the reaction, containing H2O2 concentration, time, different solvents, and nanocatalyst dosage, were investigated. XRD, FTIR, EDX, FESEM, and VSM analyses were applicated to confirm the size of morphology and structure of the prepared samples. Easy separation, excellent conversion, good recoverability, magnetic catalyst separation, low time, excellent function, and ultrasound irradiation can be named as some highlighting features of this project.

Different components of emotional responding may be affected by using specific emotion regulation strategies that enable children’s volitional self-regulation. This study examined the affective, cognitive, and physiological effects of experimentally instructing children to deploy distraction and reappraisal to regulate negative emotion during an evocative film clip. One-hundred eighty-four 4- to 11-year-old children (M = 7.66 years; SD = 2.33 years; 94 girls) participated. Neither strategy affected observed distress or self-reported negative emotion. Relative to a control condition, children instructed to use reappraisal reported marginally less happiness after the emotional film and attenuated rumination. Distraction also predicted attenuated rumination, as well as a pattern of parasympathetic reactivity indicative of disengagement that correlated with parents’ reported use of minimizing and punitive emotion socialization practices. Findings underscore the utility of multi-method approaches that examine parasympathetic activity in conjunction with volitional measures of self-regulation.

Heart rate variability (HRV) theoretically provides a biomarker for self-regulation, although studies with young children offer mixed findings regarding the relevance of emotional demands in this link. We aimed to describe variation in children’s HRV during tasks with relatively high and low emotional load, and to determine the relation of HRV during these tasks to different behavioral measures of children’s self-regulation. Electrocardiograms were recorded in 80 3 - 5-year-olds (M = 57 months; 54% male, 47% female) while they completed a Go/No-go task with low emotional load and an emotionally challenging Delay Frustration task. Mean HRV was similar across these tasks, although it increased during a between-task rest interval. Accounting for age, gender, and caregiver education, higher HRV during both tasks, but not during rest, correlated with children’s executive function task performance. HRV during Delay Frustration correlated with caregiver-reported self-regulation, whereas greater HRV withdrawal during tasks correlated with children’s task-related negative frustration. Children’s maintenance of HRV during emotional and cognitive challenge may support their effective self-regulation.

Abstract Purpose The main objective of this study is to characterize and analyze modified peptides in DBS samples. This includes deciphering their specific PTMs and understanding their potential impact on the population or disease cohort under study. Experimental design Using mass spectrometry-based proteomic approaches, we performed a comprehensive analysis of DBS samples. Our focus was on the identification and quantification of modified peptides. We also took advantage of recent advances in DBS mass spectrometry to ensure accurate detection and quantification. Results A comprehensive analysis identified 976 modified peptides in DBS samples. Of these, a subset of 211 peptides was consistently present in all samples, highlighting their potential biological importance and relevance. This indicates a diverse spectrum of PTMs in the proteome of DBS samples. Conclusions and clinical relevance Integration of mass spectrometry and proteomics has revealed a broad spectrum of modified peptides in DBS samples and highlighted their importance in biological processes and disease progression. Accurate detection of these PTMs may be critical for risk stratification and disease management. This study improves the understanding of molecular mechanisms underlying biological processes and disease development, providing important insights for clinical applications.

A document by Giorgia De Moliner. Click on the document to view its contents.

Acute glaucoma’s main sign is acute ocular hypertension (AOH), leading to retinal ganglion cell (RGC) death and irreversible visual loss. However, there is currently no approved effective therapy for this condition. This research aimed to identify the major regulators and the overall protein changes involved in AOH-induced RGC death. Mass-spectrometry was used to analyze proteomic patterns in the retinal protein extracts from the AOH and sham-group, and then Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway studies were performed. In proteomics analysis, we identified 92 proteins in the AOH group compared to the control group, with 58 proteins being up-regulated and 34 proteins being down-regulated. Western blot and biochemical assay analyses identified changes in Fatty acid-binding protein 7 (FABP7), and caveolin-1(Cav-1) that were related to fatty acid metabolism and ocular inflammatory signaling. Moreover, variations in the expression of the proteins Galectin-1 (Gal-1), S100 calcium-binding protein A6 (S100a6), and Visinin-like protein-1 (VILIP) was shown, all of which were associated to the process of neuronal ischemia. Our investigation demonstrated that neuroinflammation and fatty acid metabolism were involved in retinal impairment following AOH, offering a potential therapeutic strategy for acute glaucoma.

Natural hybridization can impact species diversity as an important evolutionary process and it is very common in Begonia, a mega-diverse plant genus. Recently, a natural hybrid between Begonia palmata and B. circumlobata was found in three locations of southeast China. It is very similar to B. palmata and difficult to identify only based on morphological characters. According to the maternal uniparental inheritance of chloroplast genome and biparental inheritance of nuclear genome in Begonia, nuclear locus (ITS) and chloroplast loci (rpL16) phylogenetic trees were constructed for the putative hybrid and its parents. The results indicated that the putative hybrid is an F1 generation with B. palmata mostly as maternal parent and B. circumlobata as paternal parent. The hybrid is described and illustrated as a new species (Begonia × yueminensis D.K.Tian et C.Z.Yang), and it is morphologically compared with its allied species.

Background: Allergic rhinitis is the specific inflammation against allergen by immune defense cells on nasal mucosa, which can lead to chronic nasal symptoms such as sneezing, itching, runny nose, and nasal congestion. it is associated with high morbidities including sinusitis, asthma, otitis media, hypertrophied inferior turbinate and nasal polyp. Despite its complications, it remains poorly recognized and tracked. Methods: A cross-sectional hospital based study was done, a total of 221 patients received ORL services at Kilimanjaro Christian medical Centre during study period were interviewed all patients with a clinical diagnosis of allergic rhinitis were captured; Data was collected using a pre-tested coded questionnaire (SFAR) The data was then analyzed by SPSS version 22. Results: A total of 221 patients with clinical diagnosis of allergic rhinitis were approached in Six (6) months study period, 111 (50.2%) were females, 140 (63.4%) were residing in urban areas. The prevalence of allergic rhinitis was 23.9%. Factors such as age OR 0.12, 95% C.I (0.03; 0.40), education OR 0.13, 95% C.I (0.04; 0.44), occupation OR 3.75, 95% C.I (1.36; 10.32), Adenotonsillar hypertrophy OR 4.66, 95% C.I (2.21; 9.80) and OME OR 4.11, 95% C.I (1.32; 12.83) (p=0.009) was found to be significantly associated with allergic rhinitis. 60.4%, Inferior turbinate hypertrophy was the leading co-morbidity of allergic rhinitis which accounts 64.7%. Conclusion: Allergic rhinitis is among the common health problems affecting Tanzanians. It is a commonly seen disorder in younger age (<15 yrs) which is in correlation with other studies done in Africa and worldwide.

Introduction: Without a care coordination mechanism, caregivers of neurodivergent children coordinate care across various complex systems in addition to caregiving responsibilities. This study aimed to understand the needs of families with neurodivergent children before entering a care coordination program. Methods: Using a convergent parallel design close-ended questionnaires and semi-structured interviews captured caregiver-reported quality of life, care integration, and resource use of 67 families. Results: Over 50% of respondents lacked access to neurodiversity related support services mainly due to information and coordination challenges. Caregivers were excluded from care planning and dealt with a fragmented system. Financial losses, social isolation, and mental health issues caused by lack of support, negatively impacted caregiver quality of life. Discussion: To improve quality of life outcomes for this demographic, this study recommends that implementing a care coordination program needs to consider the high health, educational, and social needs of families with neurodivergent children.

The α Lβ 2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1. Although members of the chemokine family of G-protein coupled receptors and heterotrimeric G proteins are known to influence LFA-1 activation and ICAM binding, the role of these receptors and their downstream effectors has not been fully characterised. In addition, a number of kinases are activated in response to LFA-1/ICAM-1 signalling in T-cells but the extent to which the kinome influences T-cell migration is not fully understood. In this study we screened two RNAi libraries targeting G protein-coupled receptors (GPCR)/GPCR-associated proteins and kinases in a HuT-78 T-cell line model of LFA-1-stimulated T cell migration. Based on staining of the actin cytoskeleton, multiple parameters to measure cell morphology were used to assess the contribution of 1109 genes to LFA-1-mediated T cell polarity and migration. These RNAi screens identified a number of both novel and previously identified genes that either increased or decreased the polarity and migratory capacity of these cells. Following multiparametric analysis, hierarchical clustering and pathway analysis, three of these genes were characterised in further detail using primary human T-cells, revealing novel roles for the heterotrimeric G protein subunit Gβ1 and casein kinase 2 in LFA-1-mediated T-cell polarity and migration in-vitro. Our studies also highlighted a new role for ICAP-1, an adaptor protein previously described to be associated with β1 integrins, in β2 integrin LFA-1-directed migration in T-cells. Knockdown of ICAP-1 expression in primary T cells revealed a role in cell polarity, cell velocity and transmigration towards SDF-1 for this adaptor protein. This study therefore uncovers new roles for GPCR/GPCR-associated proteins and kinases in T-cell migration and provides potential novel targets for modulation of the T-cell immune response.

Background: SQSTM1/p62 is an autophagy-related receptor protein that participates in regulating tumorigenesis and multiple signaling pathways. Gastric cancer is a common tumor in the digestive tract and continues to pose a significant threat to human health. Therefore, this study aims to investigate the impact of p62 on gastric cancer. Methods: Immunohistochemistry and Western blotting were employed to assess the expression level of the p62 protein in gastric cancer tissues and its correlation with prognosis. Subsequently, in vitro cell experiments were conducted to determine the role of p62 in gastric cancer cell proliferation, migration, and metastasis. Result: The expression of p62 in gastric cancer tissues was significantly higher than in normal tissues. The expression of p62 was positively correlated with poor prognosis in gastric cancer patients. In vitro cell experiments indicated that p62 promotes gastric cancer cell proliferation and migration. Mechanistically, elevated p62 expression induced epithelial-mesenchymal transition (EMT), leading to upregulation of E-cadherin and downregulation of N-cadherin and vimentin. Conclusion: This study provides novel and robust evidence for the mechanism by which elevated p62 expression promotes the progression of gastric cancer. It offers promising therapeutic targets for anti-tumor treatment strategies in gastric cancer patients.

Introduction: This systematic review aims to synthesize evidence for use of repetitive transcranial magnetic stimulation (rTMS) in recently diagnosed psychotic disorders to determine whether rTMS could be an effective treatment for early psychosis. Methods: PubMed, CINAHL, and PsycInfo were searched to obtain relevant articles published between 2012 and 2023. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Articles was used as a guideline for reporting. Two authors independently screened articles using inclusion/exclusion criteria. Those meeting criteria were examined in detail, with bias scoring via the Cochrane Risk of Bias tool. Results: Of 2155 articles yielded from the initial search, fifteen ultimately met inclusion/exclusion criteria and were examined further. Most of the studies used the PANSS to assess outcome, and the majority (89%) reported significant effects on negative symptoms following rTMS, with mixed outcomes for positive symptoms. The most common neural target for stimulation was the dorsolateral prefrontal cortex. Seventy-three percent of articles examined neural correlates of outcome, linking outcome to functional connectivity, grey matter volume, and BDNF levels. The majority of studies were rated as some or high bias, due to lack of rigorous controls, lack of blinding, or lack of randomization. Conclusions: Our systematic review suggests that rTMS is effective for treatment of negative symptoms of early psychosis. Negative symptoms are of particular clinical import as a treatment target, given their impact on function, their resistance to conventional treatments, and prognostic significance. Limitations and future directions are discussed.

Background: Fever of undetermined origin (FUO) is a challenging entity with a striking presence in hospitals around the world. The main etiologies are infectious, neoplastic, and non-infectious inflammatory diseases. At present, the clinical characteristics of non-infectious inflammatory diseases are less well described, the aim of this study is to analysis the features of non-infectious inflammatory diseases, more efficient differential diagnosis of FUO. Methods: A total of 444 patients with non-infectious inflammatory fever were retrospectively studied, and another 133 patients with infectious fever act as control group, to analysis the clinical features of non-infectious inflammatory fever. Results: The pathogenesis of non-infectious inflammatory fever were longer than infectious fever, and the levels of WBC, NEU, PLT, ESR, LDH, α-HBDH, and FRT were increased obviously in non-infectious inflammatory fever group, but the levels of RBC, HGB, LMY, and LCR were dropped, and the positive rate of anti-nuclear antibodies, anti-RNP/Sm, anti-ds-DNA, anti-Sm, anti-nucleosome, anti-histone, anti-ribosomal P protein, anti-SSA, anti-SSB, and anti-Ro-52 antibodies in non-infectious inflammatory fever patients were higher than infectious fever, the concomitant symptoms of feeble, arthralgia, skin rash, and lower limb edema were higher incidence in non-infectious inflammatory fever, but the headache was lower incidence in non-infectious inflammatory fever, the incidence of pericardial effusion was higher in non-infectious inflammatory fever, but the incidence of pleural effusion was lower in non-infectious inflammatory fever. Conclusion: The patients of non-infectious inflammatory fever have longer pathogenesis, and the levels of white blood cells, neutrophils, platelets, erythrocyte sedimentation rate, lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, and ferritin were increased, the levels of red blood cells, hemoglobin, lymphocytes, and lymphocyte to C-reactive protein ratio were dropped, many autoantibodies were included, and the incidence of feeble, arthralgia, skin rash, lower limb edema, and pericardial effusion were higher, but the incidence of headache and pleural effusion were lower.

An efficient and simple one-pot synthesis of structurally diverse novel tetrahydroquinolin fused iminosugars was developed through the aza-Diels-Alder(Povarov mechanism) mechanism. The adaptability of this method has been demonstrated by a variety of imines and D/L-ribose tosylates, and both electron-donating and withdrawing substituted imines are employed in reaction well. In addition, this reaction is characterized by simple operation, good yield, and high atom economy. Some synthetic iminosugars showed moderate anti proliferation of HCT116 tumor cells.

Background Respiratory Sinus Arrhythmia Reactivity (RSA-R) correlates both positively and negatively with externalizing behavior in autistic individuals. These inconsistencies may result from task-based differences. Furthermore, RSA-R is understudied in young autistic children, despite particular challenges with externalizing behavior. This pilot study measured RSA-R in 4-to 6-year-olds, across two time-points, using four validated tasks with matched baseline and challenge periods. Methods RSA and parent-reported externalizing behavior were collected from 17 children (Mage=5.57 years). RSA-R was measured by the difference score of the challenge task minus its corresponding comparison task. Correlations were computed to evaluate relationships between RSA-R and behavior. Results RSA was reliably measured for 3/4 tasks (.694 ≤ ICCs ≤ .896). Only RSA-R during a social task correlated with externalizing behavior. These results support using a battery that measures a range of challenges, differing in social demands, to characterize how arousal contributes to emotion regulation demands among young autistic children.

Purpose: At the molecular level, disc degeneration (DD) has been associated with dissociation of matrix assembly, leading to the loss of structural integrity. As a result of matrix dissociation, tissue ECM proteins are expected to leak into the newly developed blood vessels that circulate in the peripheral blood, indicating diseased states. Experimental design: To identify the IVD tissue-ECM proteins leaked into diseased plasma, global proteomic analysis was performed on 10 healthy volunteers (HV) and 10 diseased subjects (DS) after depletion of highly abundant proteins such as Albumin and IgG. Results: 28 proteins were identified as matrix-associated proteins identical to the proteins found in intervertebral disc tissues. Of these, 26 were from DS and 21 from HV. Among these candidates, aggrecan and fibulin 1 were found to be up and downregulated significantly in the DS group. Interestingly, diseased plasma had a specific expression of COL2A1, native to the nucleus pulposus. Conclusions and clinical relevance: The upregulated and unique presence of aggrecan and collagen type 2A1 respectively in diseased plasma remains indicative of intervertebral disc disease progression. This identification could aid in understanding the altered protein signature that remains indicative of tissue damage and the circulation of damaged tissue products.

Purpose: To clarify the different proteins between primary acquired nasolacrimal duct obstruction (PANDO) patients and healthy people and to explore the underlying pathogenesis. Methods: We collected tears from research subjects and used proteomics methods to determine protein expression.The target differential proteins were screened by bioinformatics analysis and and provide proof of histological staining Results: The proteomics experiments included 4 patients and 4 controls, all female. A total of 369 differential proteins (DEPs) were identified between two groups (FC > 1.5, P value < 0.05). The DEPs are mainly involved in the immune response and inflammatory processes, included ELANE and CTSG. Immunohistochemistry experiments found the positive expression of ELANE and CTSG in the PANDO nasolacrimal duct, but expression was not related to the degree of pathological injury (P=0.929; P=0.779). ELANE and CTSG was significantly higher in chronic dacryocystitis than in acute (P<0.001; P=0.031; P=0.031). There was a significant positive correlation between ELANE and CTSG expression. Conclusions: PANDO patients have tons of DEPs in tears compared to healthy people, which are mainly involved in inflammatory and immune processes. The positive expression of ELANE and CTSG and are strongly associated with a chronic inflammatory process of PANDO.

Thyroid cancer has become the solid tumor with the most rapidly increasing incidence. In this study, patients who underwent ultrasound examination and surgical treatment at the Run Run Shaw Hospital Affiliated to the Medical College of Zhejiang University from January 2019 to June 2020 were enrolled. Preoperative ultrasound evaluation and postoperative pathological confirmation were used to partition cases into papillary thyroid carcinoma (PTC) high-risk (C1), PTC low-risk (C2), and control (N) groups with normal thyroid tissue adjacent to the cancer. Proteomic and phosphoproteomic assays were performed on PTC tissues. The C1/N and C2/N differential proteins were significantly upregulated and the functional areas were concentrated in amino-acid binding, phosphate-compound binding, and serine peptidase activity. The significantly upregulated C1/C2 differential proteins were NADH dehydrogenase, ATP convertase, oxidoreductase activities, and iron ion channels. Based on the differential multiples, significance, and metabolic pathways of the differentially expressed proteins, eight potential biomarkers related to the diagnosis of thyroid papillary carcinoma metastasis were revealed., including phosphorylated myosin 10, phosphorylated proline alanine protein kinase, leucine tRNA ligase , 2-oxoisovate dehydrogenase, succinate semialdehyde dehydrogenase ADP/ATP translocase, malonyl COA decarboxylase, fibrin. We confirm that proteomics and phosphoproteomics can be used as effective methods for screening the metastasis of PTC.

OBJECTIVE Empagliflozin can effectively improve the renal function of diabetics, while its mechanism has still remained elusive. In this study, the differentially expressed proteins in plasma exosomes of patients with diabetic nephropathy before and after treatment with empagliflozin were analyzed by proteomics, and the possible mechanism of empagliflozin in improving diabetic nephropathy was explored. METHODS Bioinformatics analysis of differentially expressed proteins in serum exosomes of 7 patients before and after using empagliflozin was performed using the 4D label-free quantitative proteomics. RESULTS Electron microscopy, negative staining, nanoparticle tracking analysis (NTA), and Western blotting confirmed that the isolated exosomes had high purity, and 3110 proteins were totally identified by mass spectrometry. Compared with before treatment, there were 35 upregulated differentially expressed proteins and 78 downregulated differentially expressed proteins after treatment with empagliflozin. The results of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed that these differentially expressed proteins were mainly involved in important biological processes, such as blood coagulation, complement activation, protein polymerization, fibrin clot formation, and acute phase reaction. CONCLUSION Before and after treatment with empagliflozin, there were certain differences in levels of differentially expressed proteins in plasma exosomes of patients with diabetic nephropathy.

Objective: Dandelion detoxification lotion (DDL, number Z01080175) clears heat, detoxifies, activates the blood circulation, reduces swelling, and dispels decay and pus. The aim of this study was to investigate the mechanism of action by which DDL functions in the treatment of venous ulcers (VUs). Methods: Normal tissues as well as VU tissues before and after DDL treatment were collected from nine VU patients in the hospital with ethical approval. These three tissues were subjected to Prussian blue iron staining, immunoblotting, immunohistochemistry, immunofluorescence, and qPCR to detect the expression of ferroptosis suppressor protein 1 (FSP1), coenzyme Q (CoQ) 4-hydroxynonenal (4-HNE), and glutathione peroxidase 4 (GPX4). After successful validation of the heme-induced human foreskin fibroblast (HFF) ferroptosis model, lyophilized DDL powder was added to the cells, and the cells were subjected to viability assays, immunoblotting, flow cytometry, glutathione (GSH) and malonaldehyde (MDA) assays, electron microscopy and qPCR assays. Results: Ferroptosis in VU tissues was stronger than that in normal tissues, and ferroptosis in VU tissues after DDL treatment was weaker than that before treatment. Inhibition of CoQ and FSP1 and transfection of FSP1 influenced the effects of DDL. Conclusions: Our results suggest that DDL may promote healing by attenuating ferroptosis in VUs and that DDL may promote VU healing by modulating the CoQ-FSP1 axis.

Children living in coastal areas are particularly exposed to hazardous environments yet there is little research emanating from low and middle-income countries to unravel the concept of child safety and its implications for growth and development. A phenomenological study was conducted with twenty parents living in a coastal slum area in the Western Region of Ghana. Parents in this fishing community reported feeling bothered about significant threats to the safety of their children but also admitted serious challenges with maintaining the safety of their children. Well-designed safety-promoting behaviour change interventions are needed in such communities.