Objectives: Summarized the clinical characteristics of non-high risk neuroblastoma with spinal canal involvement. Patients and Methods: Retrospective, single center cohort study of non-high risk patients treated for NB (from March first 2007 to June 30th 2019) with intraspinal extension. We used the Kaplan-Meier curve to analyze and describe the prognosis. All patients followed up to April 30th, 2020. Results: 46 patients were included among the 371 patients. Median age was 13 months, median course of disease was 1 month and median follow up time was 39.5 months. The most prevalent initial symptoms were neurological motor and sensory deficit. The primary sites of the patients were posterior mediastinum. There were 19 patients divided in low risk group and others were in middle risk group. None patient died during the follow up time and 2 patients with progression of the primary disease. 24 cases received neurosurgical intervention, 18 patients’ muscle strength can recover gradually. 8 patients who with sphincter dysfunction received laminectomy and all patients recovered normal. There was an obvious improvement for pain of nerve root in the 17 patients. 14 patients with scoliosis before the laminectomy and the operation didn’t cause an aggravation of the condition. Conclusion: There was a short course and young age at diagnosis to the patients. The primary site usually located in posterior mediastinum. The highest prevalence of initial symptom was muscle strength abnormal. Neurological surgery combined with chemotherapy may relieve the symptoms of spinal canal compression effectively, and improve the quality of life.

A Retrospective Analysis of Intensive Care Unit Patients During the Pandemic Period

Human epidermal growth factor receptor (EGFR) has been established as a primary druggable target for the treatment of patients with diverse cancers. The receptor-associated late transducer (RALT) protein is a negative regulator of EGFR signaling by using its Seg1 segment to bind at the allosteric dimerization interface of EGFR kinase domain to disrupt the dimerization and then inactivate the kinase. Previous studies found that the Seg1 adopts three separated hotspots to interact with the EGFR dimerization interface, in which the third hotspot (TH) is located at the core region of the interface but its derived TH peptide (356PKYVS360) and Tyr358Phe mutant (356PKPVS360) cannot bind effectively to the interface in an independent manner (KD > 1000 μM). In this study, we demonstrate that the TH peptide can be converted from nonbinder to a moderate binder of EGFR by just adding an orthogonal nonbonded interaction system (X∙∙∙O∙∙∙H) between a halogen bond and a hydrogen bond involving peptide Phe358 residue and EGFR Val948/Trp951 residues. Both the hybrid quantum mechanics/molecular mechanics (QM/MM) and electron-correlation quantum chemistry calculations are utilized to rigorously characterize and rationally design the X∙∙∙O∙∙∙H system, which is then optimized with different halogen atoms and at different substituting positions. It is revealed that there is a synergistic effect between the halogen bond (X∙∙∙O) and hydrogen bond (H∙∙∙O) of the orthogonal interaction system; formation of the halogen bond can enhance the interaction strength of the hydrogen bond. In silico energetic analysis and in vitro fluorescence assay reach a consistence that Br-substitution at the m-position of peptide Phe358 phenyl moiety is the best choice that can render strong interaction for the X∙∙∙O∙∙∙H system (ΔEX•••O = -3.48 kcal/mol for X∙∙∙O and ΔEH•••O = -2.57 kcal/mol for H∙∙∙O), which also makes the peptide ‘bindable’ to EGFR kinase domain (KD = 247 μM), while F/Cl/I-substitution at the same position can only improve the peptide affinity moderately or modestly (KD = 835/582/690 μM). In contrast, the Br-substitution at the o- and p-positions of peptide Phe358 phenyl moiety cannot define effective X∙∙∙O∙∙∙H interaction and thus does not confer additional affinity to the EGFR–peptide complex (KD > 1000 μM).

In this study, the Delft model has been modified for the prediction of pressure drop, load point, liquid hold-up, and surface area design in the “wet gas-Tri Ethylene Glycol (TEG)” dehydration pilot plant. These parameters were used to predict the height of a transfer unit (HTU) and height equivalent to a theoretical plate (HETP) for different commercial structured packing materials and compared with existing experimental data. Improved modeling of the effective interfacial area is a key requirement for increasing the reliability and overall accuracy of the models. The mass-transfer model has been reviewed against a variety of structured packings for desorber and absorber pressures ranging from 3.81 to 9.83 barg. In this paper, the Separations Research Program (SRP), Delft and modified Delft models have been validated for different types of corrugated metal type structured packings.

Objective: Laryngeal chondrosarcomas (LCS) are rare tumors with good prognosis. The coexistence of LCS and cervical metastasis of papillary thyroid carcinoma (PTC) is scarce. The main objective of this research was to review clinical aspects and management of LCS . A secondary objective was to find the coexistence of LCS with cervical Lymph node metastasis of papillary thyroid carcinoma (LNMPTC) in all the cases included in the search. Design: A Systematic Review was performed using PubMed, Web of Science, Scopus and Embase databases. We followed PRISMA guidelines and the PECOS method to characterize different aspects of LCS. Reports of laryngeal chondrosarcoma were included and information about symptoms, imaging technique, treatment modality, histopathological diagnosis, location, tumor size, recurrence, and follow-up data was extracted. Results: Three hundred and eighty one cases of LCS were included. The average age was 61.1 years. The most common symptoms were dyspnea and hoarseness. Cricoid cartilage was the most usual location. Survival was affected by histologic differentiation, tumoral location and surgical technique. We identified the coexistence of LCS and PTC in 2 cases. In none of them the authors reported LNMPTC. Conclusion: The coexistence of LCS and PTC is rare. LCS is a tumor with good prognosis. Different approaches are described in literature.

Purpose: The work value of operating room (OR) nurses is directly reflected in the nursing quality are identified. However, there is not enough evidence to evaluate the work value for those. This study aims to evaluate the impact of fixed care teams for nursing quality in the OR. Methods: This study was conducted from July 2015 - June 2018 in Zhanjiang, China. The nursing quality indicators used in the operating room were those defined by Li-Hua Huang in China, which included 23 nursing-sensitive quality indicators. Data were collected through a survey of the registry systems of the operating room, nosocomial infection departments, quality control departments and electronic medical records. The primary end point was the rate of surgical site infections during in-hospital visits, and other nursing-sensitive quality indicators were also assessed with historically controlled data. Results: This study included 8392 surgical patients who were observed over three years. The period with fixed care teams in the operating room demonstrated a reduction in turnover time (OR 3.405, 95% 2.760-4.210, P<0.0001), a reduction in surgical site infections (OR 0.559, 95% 0.333-0.927, P=0.0231), and a significant improvement in team satisfaction (OR 0.067, 95% 0.0385-0.096, P=0.0017). We did not find significant differences between the period with and without fixed care teams in terms of other indicators. Conclusion: The use of fixed care teams in the operating room reduced turnover time and surgical site infections in orthopaedic surgery and improved team satisfaction. Whether fixed care teams are effective needs further research in other professional operating room settings. Clinical relevance: These findings contribute to leadership development for Operating Room Nursing and Operating Room Leaders, and improved patient outcomes, while aiming at improved surgery service delivery and guiding of hospital policies and reforms.

ABSTRACT Objectives: Despite controversies, no study has systematically summarized findings from earlier studies on the effect of berberine (BBR)–silymarin on liver enzymes. Therefore, the current systematic review and meta-analysis aimed to investigate the effect of berberis aristate and silybum marianum on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in adults. Methods: Relevant studies, published up to June 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, EMBASE and Google Scholar. The mean differences and standard deviations were pooled using a random-effects model. The studies’ quality was evaluated using Cochrane Risk of Bias Tool. Out of 80 citations, 5 trials that enrolled 549 participants were included. Results: Berberis aristate and silybum marianum resulted in no statistically significant change in ALT (weighted mean differences (WMD): −0.39 mg/dl; 95% CI: −1.67 to 0.89, P=0.55), and AST (WMD: −0.44 mg/dl; 95% CI: −2.02 to 1.14, P=0.58). We did not find any significant reduction in liver enzymes following BBR–silymarin consumption in adults. Conclusion: Further clinical trials with high quality according to challenges mentioned seem to be helpful to use BBR–silymarin as a supplement for improving liver function. Keywords: Berberis aristate, Silybum marianum, ALT, AST, Meta-analysis

Background: The previous studies showed the correlation between HBsAg and serum HBV DNA levels were weak or missing. And the relationship of HBeAg and HBV DNA levels was lack. Objective：The study aims to investigate the correlation between HBeAg and HBV DNA levels, and to find an alternative tool to evaluate the HBV DNA levels for clinicians. Methods: We enrolled 1020 patients in this cross-sectional study. We divided the patients into four groups as: HBeAg positivity and negativity groups, high and low HBV DNA levels groups. Further, as to the levels of HBV DNA, we performed subgroups’ in HBeAg-positive and HBeAg-negative groups. Results: The levels of ALT, ALB and HBeAg were the independent factors for the serum HBV DNA in CHB patients. The predict model for the patients with HBeAg-positive was: M1 (high HBV DNA levels) = 1.412 × (1 for HBeAg-positive >16.15 S/CO or 0 for others) + 0.004 × (1 for ALT > 42.5 IU/L or 0 for others) −0.029 × (1 for ALB > 25.5 g/L or 0 for others) + 0.779, and the AUC was 0.606. And the predict model of patients with HBeAg-negative was: M2 (low levels of HBV DNA) = 0.385 − 0.005 × (1 for ALT > 36.5 IU/L or 0 for others) − 0.006 × (1 for TB > 11.15 umol/L or 0 for others), and the AUC was 0.609. Conclusion: HBeAg was an independent risk factor for the patients with HBeAg(+), and when the level of HBeAg was higher than 16.15 S/CO, the patients should have a HBV-DNA test, if not , we should combine with the level of ALT to determine the decision. For the patients with HBeAg(-), we should evaluate the patients to have a HBV-DNA test by the levels of ALT and TB.

Rationale, aims and objectives: The aim of the intervention study was to test the feasibility and acceptability of a time consuming and demanding lifestyle-based treatment program in women with levothyroxine-treated primary hypothyrodism with residual symptoms. In addition, the influence of the intervention on participants’ health-related quality of life was assessed. Methods: 14 participants were recruited through an online questionnaire of symptom burden and health related quality of life in patients with levothyroxine-treated primary hypothyroidism. The intervention consisted of three parts: 1) diet including dietary supplements; 2) stress and sleep management; 3) physical exercise. Participants were interviewed at the end of intervention, and 6 and 12 months after intervention. Follow-up questionnaire assessements of health related quality of life (WHODAS 2.0) were made at 6, 12, 18 and 24 months after start of intervention. Results: A very low drop-out rate – 1 in 14 – and a high attendance rate indicate that the intervention program was feasible. Compliance was high, particularly regarding dietary changes and dietary supplement intake. Health-related quality of life improved; the WHODAS score was decreased with 8.5 points after 3 months intervention (p=0.004), 8.8 points at end of treatment (p=0.008) and 7.3 points at 12 months after the treatment ended (p=0.040, mixed effect regression analysis), while no significant change was seen 6 months after treatment (4.1 points, p=0.17). Conclusion: The intervention program was feasible and well accepted by the participants, who reported improvements in health-related quality of life after treatment. The efficacy of such program should be evaluated in future randomized controlled studies.

The article studied the changes of active and nutritional ingredients of Pinellia Ternata ingested by a pheasant. In the process of field experiment, it was accidentally found that pheasants liked to feed on P. ternata bulbil. To understand the effects of pheasant feeding on P. ternata, an experiment was designed immediately after pheasant feeding. The results showed that the contents of alkaloid, β-sitosterol, Phenylalanine ammonia-lyase activity, soluble sugar, free amino acid, and soluble protein in aboveground bulbil and tubers of P. ternata were significantly increased by pheasant ingestion. The secondary metabolites (except for alkaloids) and nutrients in the underground bulbil of P. ternata were significantly decreased after pheasant ingestion. Comprehensive analysis showed that the active and nutritional components in tubers and bulbils of P. ternata were affected by pheasant ingestion.

The normalized Laplacian plays an indispensable role in exploring the structural properties of irregular graphs. Let $L_{n}^{8,4}$ represents a linear octagonal-quadrilateral network. Then, by identifying the opposite lateral edges of $L_{n}^{8,4}$, we get the corresponding M\”{o}bius graph $MQ_{n}(8,4)$. In this paper, starting from the decomposition theorem of polynomials, we infer that the normalized Laplacian spectrum of $MQ_{n}(8,4)$ can be determined by the eigenvalues of two symmetric quasi-triangular matrices $\mathcal{L}_{A}$ and $\mathcal{L}_{S}$ of order $4n$. Nextly, owning to the relationship between the two matrix roots and the coefficients mentioned above, we derive the explicit expressions of the degree-Kirchhoff indices and the complexity of $MQ_{n}(8,4)$.

Plants take up nitrogen (N) both day and night. However, the molecular regulation of diurnal changes in N uptake is poorly understood. To test the hypothesis that light stimulates N uptake during the day, we examined the long-term effects of interrupted N supply (day only or night only) under hydroponic conditions. Seedlings experienced 32 days under daytime-fed (DF), nighttime-fed (NF), or continuous (CT) N supply. The root N uptake rate (NUR) differed between DF and NF from day 3 of treatment, after which NUR was significantly increased (by up to 82%) in DF and NF plants. The increased NUR during each half-day did not fully compensate for lost access to N during the other half-day, resulting in lower N accumulation by the end of the treatment. The reduction was smaller in DF plants, supporting the hypothesis that light promotes uptake. The root expression of ammonium transporter genes (OsAMT1;1, 1;2, 1;3) and a nitrogen-assimilation gene (OsGS1;2) was upregulated by 10% to 200% in both DF and NF plants relative to CT plants from day 15, more so in NF plants. No significant effect on OsG6PDH1 (in the pentose phosphate pathway) was detected.

Background and Purpose: Sepsis-induced acute kidney injury (AKI) and acute lung injury (ALI) have high morbidity and mortality, with no effective clinically available drugs. Anti-inflammation is effective strategy in the therapy of AKI and ALI. NF-κB is a target for the development of anti‑inflammatory agents. The purpose of the study is to evaluate the effect of 270, self-developed NF-κB inhibitor, in LPS-induced AKI and ALI. Experimental Approach: LPS-induced macrophages were used to examine the anti-inflammation activity of 270. Sepsis-induced AKI and ALI mice models were established by intraperitoneal injection of LPS (10 mg/kg) for 24 h. Oral administration 270 for 14 days before LPS stimulation. Plasma, kidney and lung tissues were collected and used for histopathology, biochemical assay, ELISA, RT-PCR, and western blot analyses. Key Results: In vitro, we showed that 270 suppressed the inflammation response in LPS-induced RAW 264.7 macrophages and bone marrow derived macrophages. In vivo, we found that 270 ameliorated LPS-induced AKI and ALI, as evidenced by improving various pathological changes, reducing the expression of pro-inflammation genes, blocking the activation of NF-κB and JNK pathways, attenuating the elevated myeloperoxidase (MPO) activity and malondialdehyde (MDA) content, ameliorating the activated ER stress, reversing the inhibition effect on autophagy in kidney and lung tissues, and alleviating the enhanced plasma level of creatinine (Crea), blood urea nitrogen (BUN) and pro-inflammation cytokines. Conclusions and Implications: Our investigations provides evidence that NF-κB inhibitor 270 is a potential drug against LPS-induced AKI and ALI in the future. Keywords: AKI, ALI, inflammation, NF-κB inhibitor 270

Background and Purpose As of 5 March 2021, coronavirus disease 2019 (COVID-19) has infected more than 116 million people worldwide, with over 91 million convalescent patients. A decrease in function of multiple organs has been reported in recovering patients. In China, traditional Chinese medicine (TCM) is recommended to treat patients in the rehabilitation period; however, its efficacy and safety still need to be confirmed. Experimental Approach We conducted a multicentre, double-blind, randomised controlled trial that recruited patients with COVID-19 during the rehabilitation period. In total, 131 patients were randomly divided into two groups: 66 in the Bufei Huoxue capsules (BFHX)-treated group and 65 in the control group. BFHX was administered orally three times a day (1.4g/dose) for 90 days, and the control group was administered placebo for 90 days. The primary endpoint was to evaluate improvements in fatigue symptoms and exercise tolerance. Key Results After three months of treatment, the six-minute walk distance (6MWD) of the BFHX-treated group was significantly longer than that of the control group, compared to baseline. The Fatigue Assessment Inventory (FAI) was lower in the BFHX-treated group than in the control group. Adverse event rates were higher in the BFHX-treated group, but there was no statistical difference between groups. Conclusions and Implications BFHX may have strong rehabilitative effects on patients recovering from COVID-19 in terms of improvements in physiological activities, such as fatigue symptoms and exercise tolerance. The drug has proven to have favourable safety and effectiveness profiles.

Aim: To examine the risk of individual central nervous system acting medicines used preoperatively on delirium after hip or knee surgery. Methods: A matched case-control study was conducted using data from the Australian Government Department of Veterans’ Affairs. We included people 65 years or older who had knee or hip surgery between 2000 and 2019. Cases were people with hip or knee surgery who developed postoperative delirium and controls were people with hip or knee surgery, but did not develop postoperative delirium. Use of medicines including anxiolytics, sedative, and hypnotics, opioid analgesics and antidepressants prior to surgery was compared between cases and controls. Results: Cases were more likely to be exposed to nitrazepam (OR=1.88, 95%CI=1.30-2.73), sertraline (OR=1.53, 95%CI=1.22-1.91), mirtazapine (OR=1.48, 95%CI=1.18-1.87), venlafaxine (OR=1.56, 95%CI=1.12-2.18), citalopram (OR=1.61, 95%CI=1.24-2.09), escitalopram (OR=1.39, 95%CI=1.04-1.86) or fluvoxamine (OR=3.57, 95%CI= 1.65-7.75) prior to surgery than controls. At the class level, exposure to benzodiazepines (OR=1.20, 95%CI=1.05-1.37) and antidepressants (OR=1.64, 95%CI=1.47-1.83) prior to surgery was significantly higher in cases than in controls. The numbers needed to be treated to harm in the 85 years or older age group for one additional delirium case was 20 for sertraline, 17 for citalopram, 19 for mirtazepine and 10 for nitrazepam. Conclusion: People who developed delirium following hip or knee surgery were more likely to be exposed to nitrazepam, sertraline, mirtazapine, venlafaxine, citalopram, escitalopram or fluvoxamine at the time of admission for surgery. Planning to reduce use of these medicines well prior to surgery may decrease the risk of postoperative delirium.

The current paper deals with studying the physical characteristics of blood flow through a curved catheterized diseased artery with heat and mass transfer. The constitutive equations for incompressible and steady non-Newtonian Jeffrey fluid have been modelled and solved using the corresponding boundary conditions under the mild stenosis approximation to obtain analytical solutions for axial velocity, temperature and concentration. It is observed that, by increasing the curvature parameter, the blood velocity, the arterial wall shear stress and the temperature increase while the resistance to blood flow and concentration decrease. Besides, the values of blood velocity, arterial wall shear stress, and temperature are higher for Jeffrey fluid than for Newtonian fluid, while the inverse effect is observed for the resistance to blood flow and concentration. Moreover, the trapping phenomenon depicts that the symmetry of the trapped bolus destroys due to the curvature of the artery.

Aim: This study aims to determine the relationship between beta-hCG level in vaginal washing fluid with the incidence of premature rupture of membranes (PROM) and the cut-off value of beta-hCG level in vaginal washing fluid in predicting the occurrence of PROM Materials and Methods: This diagnostic study was carried out in the delivery room of the Emergency Ward, Sanglah Hospital, Denpasar from May 2020 to July 2020. The vaginal wash was taken after delivery and then examined at the Clinical Pathology Laboratory, Udayana University/Sanglah General Hospital Denpasar Bali. Results: Thirty-five subjects that had met the inclusion and exclusion criteria were involved in this study. The cut-off value of beta-hCG vaginal washing fluid to predict PROM obtained in this study was 118.1 mIU/ml with sensitivity of 95.83%, specificity of 81.81%, positive predictive value of 92.00%, negative predictive value of 90.00%, and accuracy of 91.43%. Conclusions: Beta-hCG level in the vagina washing fluid can be used as a predictor of PROM incident Clinical Significance: The beta-hCG level may be used as a new, fast, non-invasive, promising diagnostic indicator in PROM, thus early prevention and management may be conducted to reduce the morbidity and mortality caused by PROM. Keywords: Beta-hCG, diagnostic test, premature rupture of membrane

In this paper, we apply the classical viscosity method to study the global entropy solutions to the Cauchy problem of the inhomogeneous Euler-Poisson equations of two-carrier types in one dimension with arbitrarily large initial data, and arbitrary adiabatic exponent $\gamma>1$.

Model checking continuous stochastic logic has been proven to be a powerful technique for analyzing the dependability and performance of stochastic systems. The state space explosion is the main obstacle making the technique more practical. To avoid the state explosion, a bounded model checking technique of continuous stochastic logic is proposed. First of all, the bounded semantics of continuous stochastic logic is presented, and its correctness is proven. Secondly, an effective method for computing the transient probability and steady-state probability bounded by the path length is proposed. Finally, for different operators bounded model checking procedures based on the computation of the transient probability and steady-state probability bounded by the path length are proposed. The experiment results show that if the property can be verified in local reachable space with small depth, then the bounded model checking is better than global model checking in time and space consumption.

Purpose: The purpose of this study is to evaluate the effects of nasal steroid use on the loss of smell in patients with Covid-19. Material and Method: 211 patients diagnosed with Covid-19 with positive PCR tests between April 2020 and December 2020 and followed up and treated in the Elazig City Hospital Pandemic Clinic were included in this cross-sectional study. The demographic data, comorbidities and drug use histories of the patients were interviewed face-to-face and recorded. Findings: The average age of the patients was 53.55 ± 17.81 (129 men, 82 women). Regarding the age, gender and comorbidities of the patients, there was no difference between the groups with and without loss of smell in terms of average age and gender. Anosmia developed in 50 patients (23.5%) and hyposmia developed in 84 patients (40%). No decrease or loss of sense of smell was observed in 77 patients. 26 of these patients were using nasal steroids at the time of diagnosis, and none of them had a decrease or loss in sense of smell. Results: With the results of the study, it has presented for the first time to the literature that the use of nasal steroids can prevent the loss of smell, which is one of the common neurological symptoms in Covid-19. The results of our study suggest that the nasal steroid, which plays an immunomodulatory role, can be a shield against loss of smell by creating a local anti-inflammatory effect in the nasal mucosa and around the olfactory nerve.

Background: Dyspnea is the most common symptom associated with the COVID-19 caused by novel coronavirus SARS-CoV-2. The aim of this study was to assess the prevalence of dyspnea, observe co-variables, and find predictors of dyspnea after two months of recovery from COVID-19. Methods: This study was conducted in 327 patients and they were asked if they had experienced dyspnea with the COVID-19. Patients’ responses about dyspnea were categorized as being improved, remained the same, or (worsened) two months post-COVID-19. Software “R” was used in this study for statistical computing. The p-value was set <0.05 for all statistical tests. A repeated k-fold cross-validation was used for measuring the accuracy of logistic regression. Results: Of the total 327 participants in the study, 34% had stated that they were suffering from respiratory symptoms even after two months of COVID-19. The study demonstrated that SpO2 (p value <0.03), D-dimer (p value <0.001), serum ferritin (p value <0.006) and the presence of dyspnea are significantly correlated. The repeated k-fold cross-validation method revealed that the prediction performance was around 65%. Conclusion: These findings can be useful for the physicians treating COVID-19 patients after discharge from hospital.

In this paper, we obtain lower and upper bounds for the blow-up times to a system of semilinear stochastic partial differential equations given by du1=[(Δ+V1)u1(t,x)+u1m(t,x)+u2n(t,x)]dt+k1u1(t,x)dWt du2=[(Δ+V2)u2(t,x)+u1p(t,x)+u2q(t,x)]dt+k2u2(t,x)dWt where m,n,p,q are constants. Under the assumption that m ≥ n ≥ p ≥ q ≥ 1, the distribution functions of several explosion times are obtained by using explicit solutions of an associated system of random partial differential equations and a formula due to Yor.

Aim: The aim of this study is to investigate the effect of colchicine on contrast induced nephropathy(CIN). Methods: 42 female rats were included in the study. Group1 rats were not subjected to any process. Grup2 rats were given contrast alone. Group3 rats were administered 50μg/kg/day oral colchicine 12 hours before contrast administration and simultaneously with contrast. Group4 rats were given 100μg/kg/day oral colchicine 12 hours before contrast administration and simultaneously with contrast. Group5 rats were given 50μg/kg/day oral colchicine simultaneously with contrast. Group6 rats were administered 100μg/kg/day oral colchicine simultaneously with contrast. Blood samples were collected before administration of contrast and post-contrast 48th hour, and blood urea nitrogen and creatinine levels were studied. At the same time, kidney tissue were taken and evaluated histopathologically. Results: It was found that CIN was not developed in Group1 and the groups administered contrast+colchicine. CIN was observed by 28.5% in the group administered contrast alone. Mild tubular degeneration was found in Group2 compared to the other groups(p<0.001). Evaluating for tubular necrosis and congestion, mild damage was seen in all groups, while moderate damage was observed in Group2(p=0.05). Conclusion: CIN was not developed in the groups administered colchicine. Colchicine may be effective in preventing CIN.

A 56-year-old man was admitted to our hospital for a complain of headache with a history of one week. He had a history of hypertension for more than 30 years, but his blood pressure was not well controlled with medication. After admission, it was found that his blood pressure of the lower limbs was obvious lower than that of the upper limbs. Further chest CT examination revealed that his descending aorta was severely stenosis with calcification, which may be account for his high blood pressure in upper limbs. After careful evaluation of the patient's condition, we finally adopted interventional therapy and achieved good results. After operation, the patient's upper limbs blood pressure returned to normal, and the blood pressure gradient difference between the upper and lower limbs disappeared.