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A case report of pulmonary fibroadenoma with central liquefaction necrosis
Ruxin Shen
Kai Ma

Ruxin Shen

and 1 more

January 31, 2024
Background: Generally computed tomography (CT) imaging findings of PAF present as well-defined, homogeneous and solitary nodules. Current evidence shows, no cases of PAF with central liquefaction necrosis on CT. Case Report: A 70-year-old man was hospitalized due toan inguinal hernia without respiratory symptoms. Chest CT scan revealed a tumor (about 6.5cm*5.5cm) in the lower lobe of the left lung. According to a contrast-enhanced scan, the lesion was slightly enhanced, and liquefaction necrosis appeared in the center. Wedge resection was performed by video-assisted thoracic surgery(VATS). The postoperative pathology diagnosis was PAF. Conclusion: PAF with liquefied necrosis in the center of the tumor on CT is very rare and needs to be differentiated from malignant tumors and solitary fibrous tumor through histopathology and even immunohistochemistry.
Repeated cardiac arrests in a child due to severe aortic flow obstruction by Aortic c...
Vishnu Datt
Suman Keshav

Vishnu Datt

and 5 more

January 31, 2024
In neonates and children the blood vessels are small in calibre and the correct choice of arterial and venous cannulas together with accurate placement are crucial to avoid obstructing vascular branches,and misdirecting flow or impairing venous drainage.Normally in children, to establish the cardiopulmonary bypass (CPB)one arterial cannula is inserted inthe ascending aorta,and single stagevenous cannulae, where two cannulae inserted into the superior and inferior vena cava and joined by the Y-pieceare used in the most open-heartsurgeries to facilitate the circulatory, respiratory support along with the temperature management. Rarely aortic cannulation can lead to aortic dissection, aortic posterior wall rupture leading to trauma to the esophagus, dislodgement of the aortic atheroma, fatal bleeding leading even to cardiac arrest. In addition, SVC and IVC syndrome can also occur due displacement or obstruction by the venous cannulae. However, repeated cardiac arrestsin childrenafter successful weaning from CPB,even with the use of an appropriate size aortic cannula has not been reported in the literature to date. We wish to discuss this fatal complicationafter weaning from CPB, due to aortic flow obstruction due to aortic cannula in a one-year-old, 5.5 kg child following successfulventricular septal defect(VSD) repair. The international review board approval or waiver and clinical trial registrations are not applicable for this case report publication
Gestational diabetes is associated with SARS-CoV-2 infection during pregnancy: A case...
Anda-Petronela Radan
Mihaela-Madalina Fluri

Anda-Petronela Radan

and 6 more

January 31, 2024
Objective: to investigate a possible bi-directional association between gestational diabetes (GDM) and the SARS-CoV-2 infection during pregnancy. Design: case-control study with prospective data collection for the case group and 1:2 matching with historical controls Setting: University Hospital of Bern, Switzerland Population: 224 pregnant women: 75 cases with SARS-CoV-2 infection during pregnancy, matched 1:2 with controls based on parity, BMI and ethnicity. Methods: SARS-CoV-2 infection was diagnosed by RT-PCR. Screening for GDM was performed by 75mg oral glucose tolerance test at 26 weeks’ gestation in all women. Main Outcomes: Prevalence of GDM was calculated in both groups. Multivariate binary logistic regression analysis was performed to assess risk factors for GDM and inpatient COVID-19 management. Results: 34.6% of the patients in the case group suffered from GDM, vs. 16.1% in the control group (p=0.002). 35.7% patients were diagnosed with GDM after the SARS-CoV-2 infection, vs. 33.3% diagnosed before infection (OR(95%CI) 1.11(0.40-3.08), p=0.84), with no correlation between the time-point of infection and GDM diagnosis. SARS-CoV-2 (OR(95%CI) 2.79 (1.42, 5.47), p=0.003) and BMI (OR(95%CI) 1.12 (1.05, 1.19), p=0.001) were significant independent risk factors for GDM. Conclusions: The significantly higher rate of GDM among women with SARS-CoV-2 infection during pregnancy, as compared to matching controls, suggests that GDM increases the risk of infection. On the other hand, SARS-CoV-2 during pregnancy might increase the risk of developing GDM. Vaccination and caution in using protective measures should be recommended to pregnant women, particularly those with co-morbidities. Funding: none Keywords: SARS-CoV-2, gestational diabetes, COVID-19
Re: There is no association between combined oral hormonal contraceptives and depress...
Jack Lowe-Zinola
Oguljemal Redjepova

Jack Lowe-Zinola

and 2 more

January 28, 2022
Re: There is no association between combined oral hormonal contraceptives and depression: a Swedish register-based cohort studyJack Lowe-Zinolaa, Oguljemal Redjepovab, Christopher Griffinc
COLOSSAL UTERINE LEIOMYOMA IN A ACHONDROPLASTIC FEMALE- A CASE REPORT
Jyotsna Madana
Rathnamma Papanna

Jyotsna Madana

and 1 more

January 31, 2024
COLOSSAL UTERINE LEIOMYOMA IN A ACHONDROPLASTIC FEMALE- A CASE REPORT
Spondyloenchondrodysplasia with immune dysregulation: Report of a novel ACP-5 gene mi...
Gopinathan  Mathiyazhagan
Faheema Hasan

Gopinathan Mathiyazhagan

and 5 more

January 31, 2024
Spondyloenchondrodysplasia with immune dysregulation(SPENCDI) is a rare genetic disorder resulting from suboptimal Tartrate Resistant Acid Phosphatase (TRAP) activity which key regulates functioning of immune effector cells and osteoclasts. This leads to autoimmune cytopenias along with skeletal system and neurological manifestations. Refractory autoimmune haemolysis is frequently encountered and manifest at a younger age demanding attention of a paediatric haematologist. Here we report the typical evolution of multi-systemic symptoms in a 7 year old child and difficult to manage haemolysis with use of sirolimus for attaining clinical remission.
Otolaryngologic Problems of Bone Marrow Transplant Patients in Hospital Isolation Per...
Ziya Bozkurt
Osman Kara

Ziya Bozkurt

and 3 more

January 31, 2024
Abstract Objectives: Bone marrow transplantation is a preferred treatment method for some hematological diseases. During this treatment method, patients encounter many additional clinical problems independent of their illness. Some of these problems that arise are otorhinolaryngological problems. The aim of this study is to evaluate the types and frequency of otorhinolaryngological problems seen in the hospital isolation process after bone marrow transplantation and the treatments applied to them and to draw attention to the points that the transplant team should pay attention to during the hospital isolation process of these patients. Materials And Methods: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines were followed for this original observational article. Thirty of 451 patients, who were taken into isolation after bone marrow transplantation, requested consultation from the otorhinolaryngology clinic, were included in this retrospective study using hospital records. Results: Following bone marrow transplantation, during the hospital isolation process, the most common reasons for otorhinolaryngological consultation were hearing loss and epistaxis. Conclusion: Although infections are expected more in patients after transplantation, during the isolation process after bone marrow transplantation, in terms of otorhinolaryngology hearing loss and epistaxis may be more common than infections. This situation should be kept in mind by transplant teams and patients should be closely monitored. Keywords: Bone Marrow Transplantation, Otorhinolaryngological Consultation, Hearing Loss, Epistaxis.
Engineering Saccharomyces cerevisiae for production of 2(or 5)-ethyl-5(or 2)-methyl-4...
Xiao meng Fu
Kun-Qiang Hong

Xiao meng Fu

and 4 more

January 31, 2024
HEMF(4-Hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone)is widely used as a food flavoring agent due to its unique fragrance and is in great demand. The purpose of this study is to combine enzyme remodeling and metabolic engineering methods for constructing a HEMF yield yeast strain. First, five enone oxidoreductase were selected with high sequence similarity from NCBI database and an enone oxidoreductase derived from Naumovozyma dairenensis CBS 421, named NDEO, produced higher HEMF level compared to other source of enzymes. Then, the mutant NDEOT183W, K290W was obtained by semi-rational protein engineering, which showed 75.2% increase in HEMF productivity in vitro reaction compared with NDEO. Finally, the NDEOT183W, K290W was integrated into the strain optimized for precursor supply; combined with the optimization of fermentation medium and fermentation conditions, the HEMF yield of the strain BM4 reached 103.60 mg L-1. Our study not only improved HEMF production in yeast, but also provided an effective method to improve activities of enone oxidoreductase. This work has great potential in the industrial synthesis of furanone.
Clinical Presentation and Outcomes of Hospitalized Children with Covid-19 in Mexico C...
David Diaz
Samuel Urrutia

David Diaz

and 3 more

February 11, 2022
Background. COVID-19 is usually less severe and has lower case fatality in children than in adults. We aimed to characterize the clinical and radiological features of children and adolescents hospitalized with laboratory-confirmed SARS-CoV-2 infection and to evaluate the risk factors for COVID-19-related severity in the pediatric Mexican population. Methods. We did an analysis of all patients younger than 18 years who had quantitative RT-PCR-confirmed COVID-19, admitted to the National Pediatrics Institute, and described their clinical characteristics with the radiological findings at admission, related to the severity and clinical outcome. Results. A total of 129 patients had available data showing laboratory-confirmed SARS-CoV-2 infection and were included in the sample. Among these patients the most common signs were fever (82.2%), tachypnea (72.1%) and cough (71.3%). The most frequent radiological pattern that stood out was the interstitial pattern (66.7%). History of oncologic pathology (25.6%) was the most frequent past medical history. ESR was the only laboratory value significantly associated with severity (27.82  23.83 mm/hr). NSAIDs (93%), antibiotics (57.4%), and steroids (40.3%) were the most common medication given. The average hospitalization stay was 14.2 days, 21.7% of the total patients required transfer to the intensive care unit. At discharge, 20.2% required oxygen on an outpatient basis, and unfortunately 7.0% of the patients who were admitted to the institute for COVID-19 died. Conclusions. COVID-19 in children was associated with mild symptoms and good prognosis; ESR was the only laboratory value significantly associated with severity. Patients with hematologic/oncologic co-morbidities had severe presentations.
“Loop recorder in intermediate risk HCM: should we routinely implant it ?”
chiara andreoli
Federico Fortuni

chiara andreoli

and 5 more

January 31, 2024
We present a case of syncope where the use of an implantable loop recorder was determinant to identify the cause and guide clinical management in a patient with obstructive hypertrophic cardiomyopathy at intermediate risk for 5-year sudden cardiac death.
Prospective controlled study of nasal septum deviation impact on nasal obstruction
Tomas Balsevicius
Evaldas

Tomas Balsevicius

and 5 more

January 31, 2024
Objectives: To assess the relation between the type of nasal septum deviation and the degree of subjective complaint of nasal obstruction. Methods: One hundred healthy controls and one hundred-fourteen septoplasty patients were investigated for nasal obstruction using endoscopic examination and Nasal Obstruction Symptom Evaluation (NOSE) scale. Septal deviations were classified as septal spur, C or S shape deformity at coronal or axial plane and combined deformity. The degree of septal deviation was assessed, whether the septal deviation was in contact with lateral nasal wall or not. Results: Septoplasty patients showed to have higher NOSE scores when compared to the controls. According to multiple comparison test results, patients with septal spur had significantly lower NOSE scores compared with patients with different type of septal deformity (septal spur 45.00(SD=15.80) vs. C type deformity 60.95(SD=15.25), S type deformity 63.40(SD=14.95), combined deformity 76.25(SD=8.55), p˂0.05). There was no significant difference in NOSE score according to septal deviation degree, whether the septal deviation contacts with the lateral nasal wall or not. After septoplasty the mean intervention groups’ NOSE score improved from 61.30(SD=17.20) points to 17.00(SD=15.45) points (p<0.01). Conclusions: Septal deviation, regardless of the anatomical location or shape of deviation results in impaired nasal breathing when measured by NOSE scale and compared to population average. Septal spur deformity causes significantly lower NOSE scores when compared with C or S type deformity, or combined deformity, indicating that patients with septal spur express milder symptoms of nasal obstruction. After septoplasty patients’ breathing improves significantly despite the type and location of septal deformity.
An Effective and Efficient Method to Solve the High-Order and the Non-Linear Ordinary...
Chen-Xin Qin
Ru-Hao Liu

Chen-Xin Qin

and 5 more

January 31, 2024
An effective and efficient method that solves the high-order and the nonlinear ordinary differential equations is provided. The method is based on the ratio net. By comparing the method with existing methods such as the polynomial based method and the multilayer perceptron network based method, we show that the ratio net gives good results and has higher efficiency.
On a minimal set of generators for $H^*(BE_6; \mathbb F_2)$ in the generic degree $2^...
Tin NGUYEN KHAC

Tin NGUYEN KHAC

January 31, 2024
Let $X$ be a topological space. Cohomology operations are generated by the natural transformations of degree $i$ which are so-called Steenrod squares $Sq^{i}:H^{*}(X,\mathbb{F}_{2})\longrightarrow H^{*+i}(X,\mathbb{F}_{2}),$ where $H^{*}(X, \mathbb{F}_{2})$ is the singular cohomology of $X$ with coefficients in the two-element field $ \mathbb{F}_{2},$ and $i$ is arbitrary non-negative integers. The algebra of stable cohomology operations with coefficients in $ \mathbb{F}_{2}$ is known as the modulo 2 Steenrod algebra, $ \mathcal{A}.$ Let $\mathcal P_n:=H^{*}\big(BE_n; \mathbb F_2 \big) \cong \mathbb F_2[x_{1},x_{2},\ldots,x_{n}]$ be the graded polynomial algebra over the prime field of two elements $\mathbb F_2$, in $n$ generators $x_1, x_2, \ldots , x_n$, each of degree 1, where $E_n$ is an elementary abelian 2-group of rank $n,$ and $BE_n$ is the classifying space of $E_n.$ We study the {\it hit problem}, set up by Frank Peterson, of finding a minimal set of generators for the polynomial algebra $\mathcal P_{n},$ viewed as a module over the mod-2 Steenrod algebra $\mathcal{A}$. This paper aims to explicitly determine an admissible monomial basis of the $\mathbb{F}_{2}$-vector space $\mathbb{F}_{2}{\otimes}_{\mathcal{A}}\mathcal P_{6}$ in the generic degree $2^{s+3}-6,$ with $s$ an arbitrary non-negative integer. As an application of the above results, we obtain the dimension results for the polynomial algebra $\mathcal P_n$ in degree $d= (n-1).(2^{n+u-1}-1)+\ell.2^{n+u},$ where $u$ is an arbitrary non-negative integer, $\ell =13,$ and $n=7.$
EFFICACY OF FUNGICIDES ON THE DEVELOPMENT OF POWDERY MILDEW ( Leveillula taurica ) AN...
Getachew Gebermicheal
Degife Assefa

Getachew Gebermicheal

and 2 more

January 31, 2024
Hot pepper is one of the most important spices, and vegetable cash crops cultivated during rainy and dry seasons. Powdery mildew caused by the fungus Leveillula taurica is becoming a serious threat to pepper production in South Ethiopia. The fungus causes significant damage to pepper production in irrigated fields during dry seasons. Three fungicides and five varieties had been studied in Arba Minch which is a highly prone area, The five varieties (C.annuum and C.frutescens) of pepper were sprayed with fungicides to evaluate for resistance and effectiveness of fungicides. Plots were sprayed every 7 days starting from the dates of first symptom appearance five times. The disease started at an early stage on older leaves and continues on young leaves. The mean disease severity significantly increased over time from the 7th to the 35th day. A significant (P<0.05) variation had been observed among fungicides on disease severity index(DSI), Area under disease progress curve (AUDPC), and rate of disease progress(r) of which the fungicide triadimefon significantly P< (0.05%) reduced AUDPC, rate of infection, and DSI, and showed 3.8% days; 0.039units/day; and 13% resp. and thus to minimize epidemic duration and rate of infection efficiently by 53% days and 33units/day resp. compared to Mancozeb. Among the varieties, Capsicum frutescens (Melkashote) significantly decreased AUDPC, rate of infection, and DSI revealing 3% days, 0.03units/day, and 5% resp., and reduced epidemic duration effectively by 70% and 57% days of AUDPC; and 57% and 40% units /day infection rate against (C. annuum: Alaba and Marekofana respectively). Pathogen reaction and grouping based on the level of DSI placed a variety Melkashote(5%) and Melkazala(10%) as moderately resistant; Melkaawaze(12%), and Marekofana(15%) to be moderately susceptible while the variety Alaba(22%) found distinctly susceptible. The C.annuum; Alaba and Marekofana varieties, showed the highest severity, DSI, AUDPC, and rate of infection, however, they significantly provided the highest pod yield of 1806 and 1794gm/plot respectively. Among the fungicides, triadimefon was effective to reduce the epidemics, and the varieties C. frutescens; Melkashote, and Melkazala were moderately resistant and retarded the disease efficiently.
Reduced mesophyll conductance by cell wall thickening and chloroplasts decreasing dri...
Yiwen Cao
Yonghui Pan

Yiwen Cao

and 4 more

January 31, 2024
The relationship between nitrogen (N) sources and photosynthetic capacity of leaf differs between species. However, the leaf anatomical variabilities related to photosynthesis ( A) of shrubs under different forms of N remain imperfectly known. Here, Lonicera Japonica (a shrub) was grown hydroponically in the presence of three forms of N (sole NH 4 +, 50%/50% NH 4 +/NO 3 – and sole NO 3 –). A and photosynthetic N use efficiency significantly decreased under sole NH 4 + supply, in parallel with down-regulated stomatal conductance ( g s), mesophyll conductance ( g m), and electron transfer rate ( J). Up to the total A decline of 41.28% in sole NH 4 + supply (compare with sole NO 3 –), the g m attributed to 60.3% of the total limitations. Besides, the decreased internal air space explained the increase of gas-phase resistance, and the increased liquid-phase resistance in sole NH 4 + supply was ascribed to the thicker cell wall thickness ( T cw) and decreased chloroplasts exposed surface area per unit leaf area ( S c/ S). The discrepancy of S c/ S could be interpreted by the altered chloroplasts numbers and the distance between adjacent chloroplasts ( D chl-chl). These results indicate the alteration of T cw and chloroplast numbers were the main causes of the difference in g m in coping with varied N sources.
The constricting effect of reduced coronary artery compliance on the left ventricle i...
Liang Lv
Yannan Xu

Liang Lv

and 8 more

January 31, 2024
Background: Previous studies of left ventricular diastolic function (LVDF) have focused on the decrease in active and passive diastolic function due to ischemic factors but have not investigated if the decrease in compliance of the coronary arteries that bypass the surface of the heart and travel between the myocardium could cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis. Methods and Results: From October 2016 to October 2019, the Department of Cardiology of Fengxian District Central Hospital treated 581 patients diagnosed with coronary heart disease (CHD). They were divided into groups according to the degree of coronary stenosis, the number of stents and the length of stents implanted. It was concluded that there was a statistical difference in Gensini scores between patients in groups B, C and D (P<0.001). And multiple linear regression analysis showed that T was correlated with Gensini score and C-dp/dtmax(R=0.711, P<0.001). Grouping according to the site of stent implantation and the number of stents implanted, it was found out that the changes in T values before and after left anterior descending artery (LAD) stent implantation were greater than left circumflex artery (LCX) and right coronary artery (RCA) (P<0.001). And multiple linear regression revealed a correlation between T values and stent length, ventricular stiffness, and C-dp/dtmax(P=0.001). Conclusions: The decrease in compliance of the coronary arteries bypassing the surface of the heart and travelling between the myocardium would cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis.
Primary alveolar soft-part sarcoma of the lung in children: a case report and literat...
Zhufei Xu
Jinhu Wang

Zhufei Xu

and 8 more

January 31, 2024
The Alveolar soft-part sarcoma (ASPS) involving the lung is mostly metastatic, while the primary ASPS involving the lung occurs more rarely. Herein, we reported on another case of primary ASPS, which might be with the earliest onset reported thus far. In this report, surgery was used to excise the lesion as much as possible, and its combination with chemoradiotherapy and anti-angiogenic agent may provide an important reference for the development of standard treatment or first-line treatment for these children patients. This case may provide an important reference for the development of standard treatment or first-line treatment for these children patients.
Papulonodular Mucinosis in Childhood Subacute Cutaneous Lupus Erythematosus
Perpetua Ibekwe
Emanso Umobong

Perpetua Ibekwe

and 1 more

January 31, 2024
Papulonodular mucinosis in childhood subacute cutaneous lupus erythematosus (SCLE) is uncommon. We describe a 9-year-old Nigerian boy who initially presented with recurrent, red, annular, discreet papules/plaques and later with patchy alopecia, subcutaneous nodules on both upper arms. Diagnosis was confirmed by histology, Alcian blue staining, presence of SSA antibody.
High-intensity focused ultrasound ablation combined with systemic methotrexate treatm...
yan peng
YU DAI

yan peng

and 3 more

January 31, 2024
High-intensity focused ultrasound ablation combined with systemic methotrexate treatment of intramural ectopic pregnancy following adenomyomectomy: A case reportY Peng, Y Dai, G Yu, P Jin*Department of Gynecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.*Correspondence: P Jin, MD, Department of Gynecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, China. Email pingjin66@126.comObjective To explore high-intensity focused ultrasound (HIFU) ablation combined with systemic methotrexate treatment for intramural ectopic pregnancy (IMP).Design A case report.Setting Gynaecological department in a single hospital.Population A patient diagnosed as IMP with adenomyosis 5 years post open adenomyomectomy.Methods The diagnosis of IMP was made through MRI and a 1.0-cm sinus tract was found to connect the gestational sac (GS) and endometrial cavity, and the GS was located in the adenomyosis leison. HIFU treatment combined with systemic MTX was performed.Main outcome measures Effects of HIFU combined with systemic MTX in treating IMP.Results The serum β-hCG level declined to normal 4 weeks after HIFU treatment. The GS were not foundon MRI after 4 months.Conclusions HIFU ablation combined with systemic MTX is effective in the treatment of IMP with adenomyosis and favorable for maintaining fertility.Keywords Intramural ectopic pregnancy; high-intensity focused ultrasound ablation; adenomyosis; methotrexate; adenomyomectomyTweetable abstract HIFU combined with systemic MTX is effective in treating IMP.
The safety, toleration, and pharmacokinetics comparison of two intravenous voriconazo...
Gang Chen
Zejuan Wang

Gang Chen

and 14 more

January 31, 2024
Objectives To evaluate the safety, toleration, and pharmacokinetics (PKs) comparison of two intravenous voriconazole formulations after three ascending dose administrations in healthy Chinese subjects. Methods A randomized, double-blind, placebo- and positive-controlled trial was conducted in three cohorts with a total of 42 healthy Chinese subjects. Every cohort of 14 subjects was allocated in proportion (8:4:2) to test formulation, positive voriconazole or placebo successively by single first and then multiple dose administration of 3 mg/kg, 4 mg/kg, and 6 mg/kg. Key findings A total of 41 subjects completed all drug administrations. The pharmacokinetics of test formulations are characterized by high interindividual variability with a coefficient of variance of Cmax up to 67.95% and AUC0-τ up to 70.16% and nonlinear pharmacokinetics with a regression coefficient of Cmax of 1.31 and AUC0-τ of 1.75 in a single dose. In the steady state, RAuc (mean±SD) of test drug vs positive control drug of 3 mg/kg, 4 mg/kg, and 6 mg/kg dose group was 5.18±1.07 and 5.26±0.99, 5.59±1.15 and 6.27±0.58, and 5.82±0.47 and 5.52±0.76, respectively; and Rcmax (mean±SD) were 2.50±0.44 and 2.68±0.72, 2.63±0.46 and 3.11±0.57, and 2.79±0.28 and 2.55±0.34, respectively. Adverse events with 37 transient visual disturbances were mainly mild. Conclusions The pharmacokinetics with high interindividual variability, nonlinear characteristics and significant dose-dependent accumulation were comparable in the two formulations. The overall safety of the test formulation was tolerable.
Effects of xylem conductivity loss on Scots pine and Norway spruce performance during...
Ilya Zlobin
Alexander Kartashov

Ilya Zlobin

and 4 more

January 31, 2024
The tight connection between deterioration of xylem functioning and plant mortality under drought is well recognized. However, a lack of mechanistic understanding of how substantial conductivity loss influences plant performance under drought and postdrought recovery hinders our ability to model tree responses to drought stress. We artificially modelled 50% conductivity loss in Scots pine and Norway spruce saplings by stem notching and investigated plant performance under drought and postdrought recovery. Plant mortality, xylem hydraulic conductivity, leaf water status and stomatal conductance to gas exchange were measured. We observed no preferential mortality of top plant parts (above the notching) compared to basal plant parts (below the notching), and in dying plants, no consistent trend in hydraulic conductivity loss could be observed between top and basal parts. Stem hydraulic conductance, needle water status and stomatal conductance changed in a similar manner between the top and basal parts, both during drought and postdrought recovery, thus indicating the substantial hydraulic overcapacity of the stems. The recovery of stomatal conductance demonstrated prominent hysteresis due to nonhydraulic stomatal limitations. The results obtained are of substantial importance in modelling the influence of plant hydraulic impairment on plant performance under drought and postdrought recovery.
Magnetic surfaces in Heisenberg three-group
KHADIDJA DERKAOUI
Hathout Fouzi

KHADIDJA DERKAOUI

and 1 more

January 31, 2024
In this paper, We present the contact geometry three dimensional Heisenberg group H3. We introduce the notion of the geodesic and magnetic surfaces in n-dimensional manifold. Next, as application, we determine H3 the parametric equations of such surfaces and we close the study with examples.
Silicon mediates polyamine-induced inhibition of ethylene synthesis and regulates the...
huaifeng gao
Xuelian Wu

huaifeng gao

and 8 more

January 31, 2024
Gummosis in peach is an invasive disease that causes widespread and serious damage. Mechanical damage and ethylene (ETH) can induce gummosis in peach shoots in the field. In this study, we found that silicon can induce the synthesis of polyamines (PAs) and reduce the synthesis of ETH, thereby inhibiting gummosis in peach. The results showed that silicon (Si) can decrease the rate of gummosis, reduce the expression level of PpACS1 and reduce the enzyme activity of polygalacturonase (PG). Simultaneously, the expression level of PpSAMDC and the PAs content were increased and the ETH synthesis rate was decreased. Si inhibits the synthesis of ETH by promoting PAs synthesis. It was further discovered that Si can regulate the gene expression of PpERF21 and PpERF27. Yeast one-hybrid and dual-luciferase reporter assays showed that PpERF21 and PpERF27, through direct interaction with the promoter of PpPG1, inhibited the transcriptional activation of PpPG1. Overexpression of PpERF21 and PpERF27 effectively reduced fruit colloid production when bacterial cells harbouring the expression vector were used to instantaneously infect peach fruit. These results show that Si can inhibit the synthesis of ETH by promoting PAs synthesis, mediating PpERF21 and PpERF27 expression to inhibit the expression of PpPG1, thereby inhibiting gummosis in peach.
Lipid emulsion exerts a protective effect on vital organs by LPS/TLR4 pathway in acut...
haiyan hu
gang Li

haiyan hu

and 1 more

January 31, 2024
Background:Organophosphorus poisoning is one of the common types of pesticide poisoning, which causes severe damage to vital organs. Reportedly, lipid emulsion combined with Pralidoxime significantly improves the prognosis of poisoning, but the mechanism is yet unclear;Purpose:It confirmed Lipid emulsion protect effect via LPS/TLR4 pathway on vital organs in acute organophosphorus poisoning;Methods:an organophosphorus poisoning rat model was established, and normal experimental methods were adopted. Hematoxylin-eosin (HE) observed tissue pathology, flow cytometry detected TLR4 expression, Enzyme-linked immuno sorbent assay(ELISA) detected inflammatory cytokines, and Reverse transcription PCR( RT-PCR) detected the mRNA expression of inflammatory cytokines. The role of LPS/TLR4 pathway in lipid emulsion treatment of organophosphorus poisoning was further verified by anti-TLR4. The results :It showed that after 24 h of survival, multiple organs were damaged in rats with organophosphorus poisoning. After treatment with Pralidoxime or lipid emulsion, the poisoning symptoms were slightly alleviated, but after treatment with Pralidoxime combined with lipid emulsion, the symptoms were significantly alleviated, and the expression level of TLR4 was significantly decreased in the MLT+Lipid group. After anti-TLR4 was used, the LPS/TLR4 pathway was blocked. Compared with the blocking group and the non-blocking group, the liver function and Cholinesterase(CHE) of the rats were significantly improved, the pathology of the lungs and heart were improved, and the inflammatory cytokines were significantly reduced, the symptoms of organ poisoning were relieved;Conclusion: Lipid emulsion is involved in the protective effect via LPS/TLR4 pathway on vital organs in acute organophosphorus poisoning.
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