IntroductionPeriodontal and peri-implant surgery has experienced sustained progress in recent decades, integrating new technologies and biomaterials that aim to optimize healing, reduce post-operative discomfort, and improve clinical and aesthetic results. Among these developments, cyanoacrylate-based tissue adhesives have gained interest as an alternative or complement to conventional sutures, especially in procedures where soft tissue manipulation requires precision, speed, and minimal morbidity. These biomaterials have demonstrated hemostatic and bacteriostatic properties and adequate biocompatibility, positioning them as a potentially useful tool in the oral surgical context.Periodontal and peri-implant surgery attempts to correct defects in the soft and hard tissues surrounding teeth and implants to restore health, function, and aesthetics. These procedures usually require flap elevation, manipulation, and closure, which demands tissue stabilization techniques that ensure hemostasis, reduce morbidity, and promote optimal healing 1–4. Traditionally, this has been achieved through sutures, although these have limitations such as plaque accumulation, inflammation, the need for removal in a second surgical procedure, and longer operating times 1,2. In response, tissue adhesives such as cyanoacrylates have been proposed as either an alternative or a complement to conventional sutures 3,4, representing a promising alternative to conventional sutures, however, the limited evidence currently available underscores the need for further studies to validate their efficacy and long-term outcomes.