Objectives: Frozen section (FS) can potentially guide surgeons in deciding whether to proceed with neck dissection during excision of submandibular gland tumors. However, the limitations of FS and the morphologically diverse nature of submandibular gland tumors can pose as a diagnostic challenge. The accuracy and clinical utility of FS in managing submandibular gland tumors is unclear. Our paper aims to study 1) the diagnostic accuracy of FS in detecting malignancy in submandibular gland tumors and 2) how FS can impact intraoperative decision making and management. Methods: In this retrospective case series, the FS results of 49 patients who underwent pre-operative FNAC and excision of submandibular gland between May 2008 – Dec 2023 were reviewed and compared to final histology. Results: 30/35 (85.7%) benign lesions were correctly identified as benign on FS and 5 (14.3%) were indeterminate. 5/14 (35.7%) malignant lesions were correctly identified as malignant on FS, 8 (57.1%) were indeterminate and 1 (7.1%) was falsely identified as benign. The sensitivity and specificity of FS in detecting malignancy when excluding indeterminate FS is 83.3% and 100%, and when including indeterminate FS is 92.9% and 85.7%. FS helped to prevent unnecessary neck dissections in 3/14 (21%) malignant cases by confirming absence of nodal disease. Conclusion: FS performs well in detecting malignancy in submandibular gland masses, with a high specificity and sensitivity. FS can help to prevent second surgeries i.e. neck dissection, by confirming presence of metastatic nodal disease. However, its utility may be limited if grade of malignancy cannot be determined.