Evolution under environmental influence is an undeniable phenomenon. However, the underlying molecular-level details are yet to be completely elucidated. Many studies highlight that random mutations—that arise from errors in DNA replication and repair and are conventionally regarded as the sole source of new genetic information—alone cannot completely answer evolution, given the intricateness of living systems modern science reveals, the time elapsed between species, and abrupt evolutionary events like the Cambrian explosion. Moreover, the mechanistic insight into possible non-randomness of mutations has also come to light recently, which, in addition to challenging the long-standing paradigm of random mutations, highlights the prospect of the molecular details beyond random mutations aiming at efficient adaptive variations boosting evolution. Exploring these details is crucial to fully understand the evolutionary process. In this regard, this review looks at DNA, the code of life. A growing body of studies in recent decades establish that DNA exists as chromatin, the physiological form, in all kingdoms of life and is a highly dynamic entity: It exhibits various heritable environmentally sensitive epigenetic and genetic features that interact synergistically orchestrating diverse phenotypes with environmental changes. These features enable it to modify both genome function and sequence information in response to the environment. Taken together, such findings indicate that a genome, in its physiological form, is potentially inherently capable of evolving novel lifeforms or virtually any lifeform, depending on environmental changes.