Wound infections represent a prevalent complication during the physiological sequence of tissue repair. Microneedles, as an emerging transdermal drug delivery platform, can achieve long-term intelligent management of infected wounds after loading microspheres. We herein present a microsphere-loaded microneedle patch consisting of chitosan (CG) grafted with gallic acid and polyvinyl alcohol (PT) cross-linked by TSPBA, PLGA microspheres loaded with mangiferin (MF) and an antibacterial metal phenolic network coating composed of gallic acid and silver. The multifunctional microneedle system demonstrates outstanding bactericidal efficacy，stimuli-responsive drug release of MF through pH/ROS-triggered mechanisms ，and microenvironment modulation capabilities in infected wound beds. By the 14th day, the experimental group exhibits a wound area that was merely one-fourth the size observed in the control group, showcasing a pronounced enhancement in the healing rate. The proposed methodology delineates an innovative design paradigm for developing bioresponsive microneedle systems capable of maintaining controlled pharmacokinetics while orchestrating regenerative processes in microbially compromised wounds.