Aims: This study compares the efficacy of conventional radiofrequency (RF) and high-power short-duration (HPSD) ablation in reducing the need for second interventions in patients with atrial fibrillation (AF). Methods: We retrospectively analyzed 701 patients undergoing RF ablation for AF. Patients were divided into two groups: 362 with conventional RF and 339 with HPSD ablation. The need for second interventions and pulmonary vein isolation (PVI) outcomes were assessed at 12 and 24 months. Results: The study demonstrated a significantly higher risk of reintervention in the conventional RF group compared to the HPSD group within the first two years (9.9% vs. 3.2%, P < 0.001). At 12 months, 1.5% of patients in the HPSD group required a second intervention compared to 5% in the conventional group (P = 0.009), with similar trends at 24 months (1.8% vs. 5%, P = 0.02). Kaplan-Meier analysis confirmed these findings. A greater proportion of patients in the HPSD group reached reintervention with all pulmonary veins isolated (45.5% vs. 29.6%, P = 0.167), and the mean percentage of reconnected pulmonary veins was lower in the HPSD group (18% vs. 33%, P = 0.048). Reconnection of the right inferior pulmonary vein (RIPV) was more frequent in the conventional RF group (62% vs. 25%, P = 0.021). Conclusions: HPSD ablation significantly reduces the need for a second intervention compared to conventional RF ablation, with a trend toward greater durability of PVI and comparable safety profiles.