Efficient spreading and wetting of chemical pesticides is the key development demand for increasing efficiency and reducing environmental threats. In this study, an octopus sucker bionic T/SDS aggregate was prepared to regulate droplets’ impacting and wetting process by aggregation-induced adsorption ( AIA) behavior. The T/SDS droplets showed a distinguished interfacial adsorption ability to the hydrophobic wheat leaves can lead to a remarkable decrease in the rebound height of droplets and an impressive increase in the final spread area. The aggregation-induced adsorption behavior in the spreading phase revealed the mechanism of wetting behavior of the T/SDS-regulated droplets, and was consistent with the COMSOL computation results. The T/SDS NPs also demonstrated excellent drug-delivery capacity and disease control ability against the pathogen Rhizoctonia solani in the practical application process. The aggregation-induced wetting and depositing by octopus sucker-liked T/SDS surfactant introduces a novel direction for developing of an efficient, cost-effective, and practical spreading agent to realize accurate delivery on demand in the agricultural spraying process.