[Abstract] Objective This study aimed to analyze the correlation between preoperative intravenous injection of 10% glucose and early postoperative reduction in serum albumin levels in patients with laryngeal malignant tumors, as well as its influencing factors. Methods A retrospective analysis was conducted on clinical data from 61 patients with laryngeal malignant tumors who received preoperative 10% glucose. Based on whether postoperative serum albumin levels fell below the normal reference range, the subjects were divided into two groups: the experimental group (patients with postoperative hypoalbuminemia) and the control group (patients with normal postoperative albumin levels). Factors such as age, smoking status, lymph node dissection (unilateral or bilateral), pre-existing comorbidities, surgical approach, tumor stage, preoperative albumin, total protein, prealbumin, and globulin levels were analyzed to explore risk factors influencing early postoperative hypoalbuminemia. Results The analysis revealed that 26.23% of the 61 patients who received 10% glucose intervention developed reduced serum albumin levels during the early postoperative period, suggesting a potential association between preoperative glucose infusion and abnormal postoperative protein metabolism. Univariate analysis showed statistically significant differences (P<0.05) between the hypoalbuminemia and normal groups in preoperative albumin, total protein, prealbumin, potassium levels, surgical approach, and smoking status. Multivariate analysis identified preoperative albumin, preoperative potassium levels, and surgical approach as independent influencing factors for postoperative hypoalbuminemia in patients who received 10% glucose preoperatively. Conclusion Preoperative albumin levels, potassium levels, and surgical approach are associated with the occurrence of early postoperative hypoalbuminemia in patients with laryngeal malignant tumors who received preoperative 10% glucose. [Key words] malignant tumor of larynx；Postoperative hypoalbuminemia；Preoperative glucose infusion；Risk factors；Serum albumin