Background: Liver cancer is a malignant tumor, and macrophages play a crucial role in its progression. Research on macrophages in liver cancer is increasing, however, the field still lacks comprehensive and objective bibliometric analyses. Method: A comprehensive bibliometric analysis was conducted on 4,664 papers related to macrophage research in liver cancer from 2015 to 2024, extracted from the Web of Science Core Collection using Biblioshiny, VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Office Excel Professional Plus 2016. Visual analyses were performed on publication numbers, countries, institutions, collaborations, authors, journals, keywords, thematic trends, and cited references. Result: The study shows a rising research trend with increasing global publications annually. China led in publications and citations, and ” Frontiers in Immunology” had the most publications. Keyword analysis highlighted ”expression” as a core focus, with four main clusters identified. ”Mice” had high burst intensity from 2015 to 2018, while recent hotspots included ”single-cell”, ”neutrophil extracellular traps”, and ”atlas”. Conclusion: This paper elucidates the global landscape and ongoing trends of macrophage research in liver cancer, highlighting the increasing number of investigations. China and the United States are significant leaders, but international cooperation should be strengthened. Further research is needed on the heterogeneity of macrophage functions, their interactions with tumor cells, and combined immunotherapy.