The autoclave functions as a medical device used to sterilize hospital surgical equipment and instruments. Scarcity of electrical power and fossil fuel pollution in hospitals and rural health centers emphasizes the necessity to explore different energy resources for autoclave operation. Such situations require the implementation of Solar autoclaves as an operational alternative. This research explores how well solar-powered autoclaves operate in their capacity to conduct wet sterilization processes. The solar autoclave contains a pressure vessel with Fresnel lens and reflector and porous medium. Aluminum beads exists as low-density porous material that holds unique structural and thermal characteristics. Heat transfer performance improvements through aluminum beads derive from multiple effects which encompass fluid-solid contact mechanisms and porous matrix heat distribution ability followed by fluid-heat transfer. The steam temperature inside the vessel (porous material absorber model II) reaches its peak of 128 °C. The energy efficiency achieving its peak at ɳc 74% coincided with the mid of the day at 1 pm when solar radiation intensity was at its value of 913 W/m2 for solar autoclave (porous material absorber model II) while reached ɳs (25%) for solar autoclave (flat plate absorber model I).