Digital Health Interventions (DHIs) have emerged as transformative tools for enhancing healthcare delivery in low- and middle-income countries (LMICs), addressing gaps in access, efficiency, and quality of care. However, their integration and sustainability face significant challenges related to policy, planning, and implementation. This systematic review synthesizes existing literature to identify these barriers and propose strategies for effective DHI adoption in LMICs. Following the PRISMA guidelines, the study analyzed peer-reviewed articles, institutional reports, and policy documents from 2015 to 2025. Databases such as PubMed, Scopus, and Web of Science were searched using keywords including ”Digital Health Interventions,” ”LMICs,” ”policy,” ”planning,” and ”implementation challenges.” Out of 5,000 initially identified studies, 12 met the inclusion criteria after rigorous screening. The findings reveal three major challenges: (1) Policy gaps, including fragmented governance, weak regulatory frameworks, and lack of standardized data protocols, leading to disjointed and donor-dependent initiatives; (2) Planning barriers, such as inadequate infrastructure, limited funding, and insufficient stakeholder engagement, restricting scalability; and (3) Implementation obstacles, including technological constraints, low digital literacy, and misalignment with existing healthcare workflows. Despite these challenges, successful case studies highlight the importance of context-sensitive strategies, robust policy frameworks, and sustained investments. The study concludes that addressing these systemic barriers requires inclusive governance, capacity building, and interoperable systems. By fostering multi-stakeholder collaboration and aligning DHIs with national health priorities, LMICs can harness digital health innovations to achieve universal health coverage and improved health outcomes. Future research should focus on scalable, locally adapted solutions to ensure equitable and sustainable DHI integration in resource-limited settings.