The increasing burden on healthcare systems in developing countries has highlighted the urgent need for efficient, scalable, and datadriven solutions to improve service delivery and decision-making. Information and Communication Technology (ICT)-based Health Information Systems (HIS) offer a promising avenue to address these challenges by enabling real-time data collection, analysis, and dissemination. This paper explores the architecture, applications, and effectiveness of ICT-based HIS in lowresource settings, with a focus on electronic medical records, mobile health (mHealth) platforms, and national digital registries. Through an extensive review of case studies and existing literature, the paper identifies key benefits such as improved patient tracking, disease surveillance, and resource allocation. However, the implementation of these systems is often hindered by infrastructural deficits, limited digital literacy, and policy constraints. A strategic framework is proposed to address these barriers and guide sustainable deployment. The study concludes that with the right policy, technical support, and stakeholder collaboration, ICT-based HIS can play a pivotal role in achieving universal health coverage and sustainable development goals in the Global South.