AbstractAn 80-year-old male patient was admitted to our hospital with a one-year history of recurrent reflux and vomiting, accompanied by mild fatigue and decreased appetite. Despite initial treatment with gastric motility agents, his symptoms showed limited improvement. Comprehensive diagnostic evaluations, including imaging and laboratory tests, ruled out common gastrointestinal disorders (such as peptic ulcer disease, gastroesophageal reflux disease, and functional dyspepsia), intracranial pathologies, and other systemic conditions. Based on his clinical presentation and a history of chronic glucocorticoid use, glucocorticoid-induced adrenal insufficiency was suspected as the underlying cause. Remarkably, his symptoms resolved completely following a 10-day course of hydrocortisone replacement therapy.