Background: Postpartum attachment is a multi-dimensional construct that includes maternal thoughts, behaviors, emotions and attitudes, which is influenced by both maternal and infant related factors. This study aims to investigate the factors affecting maternal-infant attachment. Materials and Methods: This study included participants who responded to the validity and reliability assessments of the ”Maternal Self-Efficacy Scale” (MSES) and the ”Postpartum Maternal Attachment Scale” (PMAS) through social media. Maternal depressive symptom levels were assessed using the Patient Health Questionnaire-9 (PHQ-9). Factors influencing attachment levels were analyzed using multiple regression models. Results: Data from 64 mothers who completed both surveys were evaluated. The infants’ ages ranged from 1 to 12 months, with a median age of 6 (3-10) months. 90.6% of the participants had at least a university degree. Maternal attachment was positively correlated with maternal self-efficacy (p<0.001, r s: 0.46) and negatively correlated with maternal depressive symptoms (p<0.001, r s: -0.41). Attachment scores did not vary according to the number of children, education level, or maternal employment status. In the multiple regression model (adjusted R2: 0.28, F (61,2): 13.772, p<0.001), both depressive symptom levels and parenting self-efficacy were found to significantly predict maternal attachment. Conclusion: This study shows that maternal depressive symptoms negatively influence postpartum attachment among highly educated mothers. Future research in this field should explore additional confounding variables and focus on interventions that take a holistic approach to peripartum care, for improving maternal-infant outcomes.