Introduction Breast cancer (BC) is one of the top causes of mortality for women worldwide. Early detection of BC along with regular breast cancer screening (BCS) has been shown to reduce mortality rates. The purpose of this study was to examine the knowledge, attitudes, and BCS-related barriers faced by women from English speaking Caribbean countries and identify areas that require further intervention to fill the gap of early BCS barriers. Methods This narrative review analyzed 25 research articles with keywords breast cancer, screening barriers, and English-speaking Caribbean countries using various databases, including PubMed, Google Scholar, MEDLINE, and ScienceDirect. Results For this review, papers were selected that focused on barriers to BCS in the specified English-speaking Caribbean and comparative study to expand understanding of extrinsic barriers beyond Caribbean territory centered among US Caribbean immigrants and African American demographic. The data were reported, arranged, and presented under the following main headings: individual factors, sociocultural factors, and health systems / structural factors for contributing to early BCS barriers. Conclusion Breast cancer remains a major public health concern in the Caribbean, despite global advancements in screening and care. Over the past five years, Caribbean women have experienced an increase in breast cancer-specific mortality. Barriers such as knowledge, fear, and stigma contribute to this decline. An organized national breast cancer screening program and research on the biology of breast cancer are urgently needed to reduce mortality rates.