[1]¿p1 [1]¿m1 Due to the lack of effective treatments, neurological diseases such as depression, Parkinson’s, and Alzheimer’s pose a serious threat to world health. D-amino acids (DAAs) have recently been shown to have the ability to modulate brain activity, providing new treatment avenues. D-amino acids, specifically D-tryptophan and D-phenylalanine, are examined in this review in relation to the treatment of neurological conditions. DAAs have unique pharmacological characteristics that affect different brain biological pathways, which sets them apart from their L-forms and makes them attractive options for targeted treatments. The history of neurological conditions and the ways that D-amino acids affect neurotransmission are the first things to look at. The review discusses D-tryptophan’s neuroprotective properties, such as its metabolism and role in serotonin synthesis, and provides information on how it may help treat mood disorders and neurodegeneration. Likewise, the processes and neuroprotective attributes of D-phenylalanine are examined, highlighting its involvement in dopamine synthesis and its therapeutic potential for disorders such as Parkinson’s disease. Furthermore, innovative tactics for improving drug delivery across the blood-brain barrier utilizing DAAs was investigated, including conjugation-based methods and solubility augmentation techniques. These strategies have the potential to transform the targeted administration of medicines. Future directions for DAAs in the treatment of neurological disorders are covered in the review’s conclusion, along with current research and possible therapeutic uses. In the end, D-amino acids offer a novel and distinctive approach to brain health and a viable path forward for improving treatment approaches in neurological illnesses.