Human adolescents are frequently exposed to ethanol and/or to noise, agents that put brain development at risk. As the use of animal models has been demonstrated to reproduce human findings, the aim of the present study was to investigate if two weeks of ethanol intake, with an intermediate noise exposure, can affect different hippocampal-related behaviors in adolescent rats of both sexes. In addition, the enriched environment was used as an environmental housing strategy to prevent hippocampal-related behavioral changes. Importantly, although partial neuroprotection has been found in an animal model of brief ethanol intake, little is known about longer intake paradigms. Adolescent Wistar rats of both sexes were subjected to voluntary intermittent two-bottle choice paradigm of ethanol intake in for 2 weeks (6 sessions). A subgroup was exposed to noise for two hours after the third session. Some rats from both groups were housed in enriched environment cages. Finally, an assessment of hippocampal-related behaviors was performed. Data show different alterations in hippocampal-related behaviors, some of which were sex-specific and differ from those observed after a brief ethanol consumption. Most behavioral changes were prevented, at least partially, by enriched environment. These findings suggest that common environmental factors present in human adolescent venues may influence behavior that differs among sexes, as observed in the present animal model of extended ethanol intake. Additionally, an enriched environment proved to be a partially effective neuroprotective strategy in both sexes. Thus, implementation of non-pharmacological approaches may provide benefits against various challenges.