Leukemia is the most common pediatric cancer and remains a leading cause of mortality in children under 15, with an estimated global incidence of approximately 400,000 cases annually among children and adolescents. Despite advancements in treatment improving survival rates, the disease and its prolonged therapeutic process impose significant physical (e.g., pain, fatigue) and psychological (e.g., anxiety, hopelessness, depression) burdens. Additionally, children with leukemia often face social and academic challenges, including difficulties with social support, adaptation, self-esteem, and educational attainment. The existing literature highlights the need for targeted interventions to address these psychological difficulties and provide holistic support. This study aimed to enhance the emotional well-being and resilience of children with leukemia by fostering a sense of solidarity and self-efficacy through mentorship from leukemia survivors. Thirteen participants (8 girls, 5 boys; mean age = 10 years) from the eastern provinces of the country engaged in structured online sessions over three months with mentors who had successfully recovered from leukemia. These mentors provided both motivational and academic support. Findings revealed statistically significant improvements in participants’ trait anxiety levels (p = 0.029), overall quality of life (p = 0.007), and coping skills related to cancer (p = 0.005). These results suggest that structured mentorship programs can positively impact the psychological and social well-being of children with leukemia. By fostering social connectedness and alleviating motivational challenges, such initiatives may contribute to improved long-term psychological health, underscoring the potential of mentorship-based interventions as a valuable component of comprehensive care strategies.