This letter critically examines the study titled ”Catheter Ablation Improves Ventilatory Efficiency in Atrial Fibrillation‐Mediated Cardiomyopathy” by Ahluwalia et al., which investigates the impact of catheter ablation (CA) on ventilatory efficiency in atrial fibrillation (AF)-mediated cardiomyopathy. While the study presents valuable findings, we raise concerns regarding the oversimplification of the relationship between left atrial volume reduction and improvements in exercise oscillatory ventilation (EOV). We argue that the factors influencing EOV, such as peripheral muscle deconditioning, altered chemoreceptor sensitivity, and systemic inflammation, were not adequately addressed. Additionally, the study’s limited electrophysiological analysis does not fully explore the arrhythmic mechanisms contributing to ventilatory inefficiency. Our letter calls for a more comprehensive evaluation of the complex interactions involved in ventilatory efficiency and the electrophysiological effects of CA.