Introduction Catheter ablation using pulsed-field energy may penetrate deeper into scarred tissue than thermal energies; however, evidence regarding its role in treating ventricular arrhythmias (VA) is limited. In this prospective study, we report our current experience on pulsed-field ablation (PFA) with pentaspline catheter for the treatment of premature ventricular contractions (PVC) originating from the right ventricular outflow tract (RVOT) and scar-related ventricular tachycardias (VT). Methods Consecutive VA patients who underwent PFA with Farapulse system were enrolled. Eight patients underwent ablation for idiopathic RVOT PVCs, and 6 patients with structural heart disease underwent ablation for scar-related VTs. The recurrence of arrhythmias was assessed by 24-hour Holter electrocardiography monitoring or implantable cardioverter defibrillator interrogation. Results Fourteen patients were enrolled, age 51±13 years, 11 were man, 4 had previously failed radiofrequency ablation. Procedural and fluoroscopy times were 76±44 minutes and 9 (4–20) minutes, respectively. The median number of PFA applications was 16 (12-19) in the VT group and 8 (7-8) in the PVC group. Acute procedural success was achieved in 86% of patients. During a mean follow-up of 136±73 days, freedom from VT was 67% and a PVC burden <1% was achieved in 75% of patients. Conclusions The ablation of idiopathic RVOT PVCs and scar-related VTs with the pentaspline PFA catheter is feasible with good acute and mid-term efficacy observed in our cohort. Further research involving larger cohorts and longer follow-up periods is needed to analyse the safety and define the role of PFA in VAs.