Mucormycosis constitutes a rapidly progressive and fatal form of invasive fungal rhinosinusitis. The reported mortality rate can reach 70%. It mainly affects patients with a defaced immune system. The lack of protocols and knowledge results in late diagnosis and poor outcomes to patients. Noticing the necessity of disclosure, we present a descriptive prospective study on 14 cases of[Rhino-Orbital Cerebral form of](https://pubmed.ncbi.nlm.nih.gov/34582509/) Mucormycosis diagnosed from 2014 to 2024 at a reference center of Brazil, with complete demographic features, clinical characteristics, therapeutic and surgical data, even as the outcomes of treatment (survival or death). The most common underlying disease was Diabetes mellitus, affecting 90% of our patients. The overall mortality rate was 35,71%. Deaths occurred at a median of 41.6 days (range 9-78 days) following diagnosis. Bilateral involvement and Chronic kidney disease (CKD) were significant predictors of mortality. Patients with bilateral involvement had a mortality rate 17.46 times higher than patients with unilateral involvement (HR = 17.46, 95% CI 1.76–173.00; p = 0.0145). Patients with CKD had a mortality rate 9.41 times higher than patients without CKD (HR = 9.41, 95% CI 1.03–86.02; p = 0.0470). After diagnosis all of them received systemic antifungals and only one did not undergo through surgery, nasal endoscopic was the used approach. In addition, delay in diagnosis was related to greater extent of the disease and more aggressive surgeries. It is essential to have a critical clinical view in order not to delay the diagnosis and consequent beginning of the therapeutic approach. Key Points: Mucormycosis constitutes a rapidly progressive and fatal form of invasive fungal rhinosinusitis. We did a prospective analysis of 14 cases in a reference Brazilian center. The described mortality reaches up to 70% and in our study was of 35,71%. ⁠It mainly affects patients with immunosuppression and in this study the most prevalent comorbidity was diabetes. ⁠Our study presented with Bilateral involvement and CKD were significant predictors of mortality.