Introduction:Qat, also known as “khat”, is an evergreen plant. It grows wildly, along with being cultivated, in many countries in African horn. It is cultivated in Yemen. Nowadays due to the ongoing civil war therein, qat represents an economic backbone for Yemeni people: Many Yemenis work in qat cultivation, transportation, and marketing.Qat is habitually chewed due to the said “amphetamine-like stimulating effect”. Indeed, qat chewing is a deep-rooted habit in Yemen and many of the African horn countries. The session of qat chewing lasts several hours. Briefly, the fresh leaves and twigs of qat are chewed to form a bolus which kept on one side of the mouth, and continually chewed to release the qat extract which swallowed and/or absorbed through oral mucosa. In Yemen, qat sessions mostly take place in gatherings. It also takes place at private works, home, or even in streets.It is well-documented that qat has economic, sociocultural, and health negative implications. These implications have been critically reviewed by Al-Shubbar [1] and Alshoabi et al. [2]. In brief, qat has been reportedly to cause (or be associated with) many systemic diseases like autoimmune hepatitis [3], and mental disorders [4]; increasing diabetes parameters like HbA1c [5]; myocardial infarction [6, 7]; adverse birth outcomes [8, 9]; adverse effects on the genitourinary system like reduced semen volume [10], toxic effects on the male fertility, and sexual health [11]; and gastrointestinal disturbances [12, 13].The burden of qat chewing on oral cavity represents a hot area of debates. Al-Maweri et al. have recently reviewed this topic extensively [14]. Qat chewing is said to have detrimental effects on dental and oral tissues including association with or inducing periodontal diseases [15, 16], dental caries [17], dental discoloration and attrition [18], temporomandibular joint disorders [19-21], plasma cell stomatitis [22, 23], mucosal pigmentation [18], white (keratotic) lesions [18, 24, 25], and dry mouth/xerostomia [14, 18]. Although no sound evidence has been available yet, a possible link between qat chewing and oral cancer has been suggested [26-30].This current report presents a case of a patient who developed extensive deep oral and oropharyngeal ulcers with bone denudation secondary to chronic qat chewing.Key clinical message : qat chewing can predispose to extensive chronic deep oral ulcers that might be associated with bleeding. Dental professionals must stress on such complications while providing qat chewing quitting counseling.