Pulmonary sarcomatoid carcinoma(PSC) is a rare, hidden-onset, rapidly progressive, poorly differentiated non-small cell lung cancer. Its accurate diagnosis is troublesome. Herein, we reported a case of pulmonary sarcomatoid carcinoma diagnosed by contrast-enhanced ultrasound angiography-guided lung biopsy. We described the CEUS imaging features in this case. These features differing from enhanced computed tomography have not been reported in previous literature.