Introduction: Bipolar disorder is linked to elevated rates of suicidal behavior and death by suicide. The objective of this study was to examine the contribution of depressive symptoms and hazardous alcohol use to suicidal behavior within a predominantly low-income African American sample of individuals with bipolar disorder. Method: We recruited 204 patients with bipolar disorder from an urban public hospital’s outpatient clinic in the Southeastern U.S. Multiple regression examined associations between depressive symptoms, hazardous alcohol use, and suicidal behavior among past-year drinkers, controlling for gender. Results: The regression model revealed that gender, depressive symptoms, and hazardous alcohol use were significant predictors of suicidal behavior. Depressive symptoms exhibited the strongest association (β = 0.367, p < .001), followed by hazardous alcohol use (β = 0.171, p = .042) and gender (β = 0.227, p = .012). Collectively, these factors accounted for 24.1% of the variance in suicidal behavior (R 2 = 0.241), underscoring their role in suicide risk among individuals with bipolar disorder. Conclusions: Findings highlight significant associations between depressive symptoms, hazardous alcohol use, and suicide risk in low-income African American individuals with bipolar disorder. Clinical interventions should prioritize comprehensive screening and targeted approaches to address these interconnected risk factors.