Objetive: Cancer is considered one of the main health problems worldwide and patients undergo sometimes aggressive treatments that can lead to relapses or readmissions that decimate their quality of life. The aim of this research was to know the prevalence and characteristics of resilience in cancer patients and how the psychological and social factors could influence the perception of the disease. Methods: Participants with different diagnosis of cancer were recruited (N = 61). Resilience was measured with the 14 items (RS-14) Wagnild and Young Resilience Scale, anxiety with Hospital Anxiety and Depression Scale and Assessment of the patient’s social environment wit APGAR score. Results: 50.8% women aged 35 to 82 years, all diagnosed with cancer (breast 18%, lung 29.5%, colon 9.8%, among others). Of these, 11.5% had not received oncological treatment, and 93.4% underwent surgery. The majority were non-smokers (82%) and 57.4% were retired. Respiratory (24.6%) and cardiovascular (23%) comorbidities were the most prevalent. In a survey, 54.1% reported having family members with cancer, and 36.1% indicated that a lack of free time negatively impacted their quality of life. The correlation analysis revealed a non-significant negative relationship between resilience and age (r=-0.023; p=0.863) and a positive correlation with BMI (r=0.088; p=0.510). Anxiety was associated with a 70% decrease in the likelihood of resilience (OR=0.72). Conversely, depression (OR=1.22) and APGAR scores (OR=1.12) were linked to a 20% increase in the likelihood of resilience. Conclusion: Our results support the idea that resilience plays a crucial role in managing mental health and quality of life in cancer patients.