OBJECTIVE: This study aims to investigate the effectiveness of multi-level integrated management strategies designed to enhance nutritional screening and support for oncology patients. METHODS: An interrupted time series model was employed to evaluate changes in the levels and trends of nutritional screening and support for inpatients before (January 2021 to January 2023) and after (February 2023 to November 2024) the implementation of management measures.. RESULTS: After a quality improvement project above the execution of extensive strategies to improve clinical nutrition services, there was a significant increase in the number of inpatients receiving nutritional screening (β3 = 125.17, P < 0.05), the rate of nutritional screening (β3 = 2.28, P < 0.05), and the nutritional treatment rate (β3 = 2.49, P < 0.05) among inpatients identified as at nutritional risk. Additionally, the number of inpatients receiving nutritional support (β2 = 481.45, P < 0.05) and the nutritional support rate (β2 = 5.09, P < 0.05) also significantly increased following the implementation of these improvement measures, with the results demonstrating statistical significance.Overall, these findings indicate a marked improvement in the nutrition screening rate, nutrition support rate, and nutritional treatment rate among hospitalized patients at nutritional risk after the policy intervention. governance strategies-including the establishment of a clinical nutrition management system, mandatory nutritional screening, adequate training, standardization of medical records documenting nutritional interventions, and the integration of clinical nutrition into multidisciplinary management to enhance clinical nutritional service-there was a significant increase in the number of inpatients receiving nutritional screening (β3 = 125.17, P < 0.05), the rate of nutritional screening (β3 = 2.28, P < 0.05), and the nutritional treatment rate (β3 = 2.49, P < 0.05) among inpatients identified as at nutritional risk.Furthermore, the number of inpatients receiving nutritional support (β2 = 481.45, P < 0.05) and the nutritional support rate (β2 = 5.09, P < 0.05) after these improvement measures were put into place, with the findings showing statistical significance.Overall, these findings indicate a marked improvement in the nutrition screening rate, nutrition support rate, and nutritional treatment rate among hospitalized patients at nutritional risk after the policy intervention. CONCLUSION: Through comprehensive management measures, nutritional screening and support for inpatients in specialized hospitals have significantly improved following comprehensive management measures. It is essential for healthcare institutions to increase awareness of malnutrition among cancer patients, prioritize early nutritional screening and assessment, and develop nutritional intervention plans aimed at improving the quality of survival for oncology patients.