In this paper, a class of hematopoietic stem cell transplantation model with virus-to-cell HIV infection is proposed to characterize the competitive exclusion and coexistence between the host CD4+T cells and donor CD4+T cells. First, the positivity and boundedness of solutions as well as the basic reproduction number R are obtained. Second, criteria on the locally and globally asymptotical stability of all feasiable equilibria are established. Furthermore, bifurcation analysis is performed on the mixed chimerism infection equilibrium. Finally, the theoretical results are illustrated by numerical simulation, we find that chimerism is an important indicator of model stability, and AIDS may be cured when chimerism reaches a certain threshold.